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Results: 1-23 |
Results: 23
DEVELOPMENT OF IRREVERSIBLE EGFR TYROSINE KINASE INHIBITORS WITH ANTITUMOR-ACTIVITY AGAINST HUMAN TUMOR XENOGRAFTS
Authors: SMAILL JB DENNY WA FRY DW NELSON JM LEOPOLD WR VINCENT PW HOOK KE ELLIOTT WL BRIDGES AJ ZHOU H SHOWALTER HDH MCNAMARA DJ DOBRUSIN EM
Citation: Jb. Smaill et al., DEVELOPMENT OF IRREVERSIBLE EGFR TYROSINE KINASE INHIBITORS WITH ANTITUMOR-ACTIVITY AGAINST HUMAN TUMOR XENOGRAFTS, Annals of oncology, 9, 1998, pp. 415-415
TYROSINE KINASE INHIBITORS - 14 - STRUCTURE-ACTIVITY-RELATIONSHIPS FOR METHYLAMINO-SUBSTITUTED DERIVATIVES OF ENYL)AMINO]-6-(METHYLAMINO)PYRIDO[3,4-D]PYRIMIDINE (PD-158780), A POTENT AND SPECIFIC INHIBITOR OF THE TYROSINE KINASE-ACTIVITY OF RECEPTORS FOR THE EGF FAMILY OF GROWTH-FACTORS
Authors: REWCASTLE GW MURRAY DK ELLIOTT WL FRY DW HOWARD CT NELSON JM ROBERTS BJ VINCENT PW SHOWALTER HDH WINTERS RT DENNY WA
Citation: Gw. Rewcastle et al., TYROSINE KINASE INHIBITORS - 14 - STRUCTURE-ACTIVITY-RELATIONSHIPS FOR METHYLAMINO-SUBSTITUTED DERIVATIVES OF ENYL)AMINO]-6-(METHYLAMINO)PYRIDO[3,4-D]PYRIMIDINE (PD-158780), A POTENT AND SPECIFIC INHIBITOR OF THE TYROSINE KINASE-ACTIVITY OF RECEPTORS FOR THE EGF FAMILY OF GROWTH-FACTORS, Journal of medicinal chemistry, 41(5), 1998, pp. 742-751
SYNTHESIS AND TYROSINE KINASE INHIBITORY ACTIVITY OF A SERIES OF 2-AMINO-8H-PYRIDO[2,3-D]PYRIMIDINES - IDENTIFICATION OF POTENT, SELECTIVE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR TYROSINE KINASE INHIBITORS
Authors: BOSCHELLI DH WU ZP KLUTCHKO SR SHOWALTER HDH HAMBY JM LU GH MAJOR TC DAHRING TK BATLEY B PANEK RL KEISER J HARTL BG KRAKER AJ KLOHS WD ROBERTS BJ PATMORE S ELLIOTT WL STEINKAMPF R BRADFORD LA HALLAK H DOHERTY AM
Citation: Dh. Boschelli et al., SYNTHESIS AND TYROSINE KINASE INHIBITORY ACTIVITY OF A SERIES OF 2-AMINO-8H-PYRIDO[2,3-D]PYRIMIDINES - IDENTIFICATION OF POTENT, SELECTIVE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR TYROSINE KINASE INHIBITORS, Journal of medicinal chemistry, 41(22), 1998, pp. 4365-4377
2-SUBSTITUTED AMINOPYRIDO[2,3-D]PYRIMIDIN-7(8H) ONES - STRUCTURE-ACTIVITY-RELATIONSHIPS AGAINST SELECTED TYROSINE KINASES AND IN-VITRO AND IN-VIVO ANTICANCER ACTIVITY
Authors: KLUTCHKO SR HAMBY JM BOSCHELLI DH WU ZP KRAKER AJ AMAR AM HARTL BG SHEN C KLOHS WD STEINKAMPF RW DRISCOLL DL NELSON JM ELLIOTT WL ROBERTS BJ STONER CL VINCENT PW DYKES DJ PANEK RL LU GH MAJOR TC DAHRING TK HALLAK H BRADFORD LA SHOWALTER HDH DOHERTY AM
Citation: Sr. Klutchko et al., 2-SUBSTITUTED AMINOPYRIDO[2,3-D]PYRIMIDIN-7(8H) ONES - STRUCTURE-ACTIVITY-RELATIONSHIPS AGAINST SELECTED TYROSINE KINASES AND IN-VITRO AND IN-VIVO ANTICANCER ACTIVITY, Journal of medicinal chemistry, 41(17), 1998, pp. 3276-3292
DEVELOPMENT OF A BINDING MODEL TO PROTEIN-TYROSINE KINASES FOR SUBSTITUTED PYRIDO[2,3-D]PYRIMIDINE INHIBITORS
Authors: TRUMPPKALLMEYER S RUBIN JR HUMBLET C HAMBY JM SHOWALTER HDH
Citation: S. Trumppkallmeyer et al., DEVELOPMENT OF A BINDING MODEL TO PROTEIN-TYROSINE KINASES FOR SUBSTITUTED PYRIDO[2,3-D]PYRIMIDINE INHIBITORS, Journal of medicinal chemistry, 41(11), 1998, pp. 1752-1763
DEVELOPMENT, STRUCTURE-ACTIVITY-RELATIONSHIPS AND ANTITUMOR-ACTIVITY OF A NOVEL CLASS OF SPECIFIC, IRREVERSIBLE EGFR TK INHIBITORS
Authors: SMAILL JB DENNY WA FRY DW NELSON JM LEOPOLD WR VINCENT PW PATMORE SJ ELLIOTT WL HOOK KE BRIDGES AJ ZHOU H SHOWALTER HDH MCNAMARA DJ DOBRUSIN EM
Citation: Jb. Smaill et al., DEVELOPMENT, STRUCTURE-ACTIVITY-RELATIONSHIPS AND ANTITUMOR-ACTIVITY OF A NOVEL CLASS OF SPECIFIC, IRREVERSIBLE EGFR TK INHIBITORS, British Journal of Cancer, 78, 1998, pp. 34-34
1-OXO-3-ARYL-1H-INDENE-2-CARBOXYLIC ACID-DERIVATIVES AS SELECTIVE INHIBITORS OF FIBROBLAST GROWTH-FACTOR RECEPTOR-1 TYROSINE KINASE
Authors: BARVIAN MR PANEK RL LU GH KRAKER AJ AMAR A HARTL B HAMBY JM SHOWALTER HDH
Citation: Mr. Barvian et al., 1-OXO-3-ARYL-1H-INDENE-2-CARBOXYLIC ACID-DERIVATIVES AS SELECTIVE INHIBITORS OF FIBROBLAST GROWTH-FACTOR RECEPTOR-1 TYROSINE KINASE, Bioorganic & medicinal chemistry letters, 7(22), 1997, pp. 2903-2908
SMALL-MOLECULE INHIBITORS OF THE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR, THE FIBROBLAST GROWTH-FACTOR RECEPTOR, AND SRC FAMILY TYROSINE KINASES
Authors: SHOWALTER HDH KRAKER AJ
Citation: Hdh. Showalter et Aj. Kraker, SMALL-MOLECULE INHIBITORS OF THE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR, THE FIBROBLAST GROWTH-FACTOR RECEPTOR, AND SRC FAMILY TYROSINE KINASES, Pharmacology & therapeutics, 76(1-3), 1997, pp. 55-71
PREPARATION OF N,N'-BIS(ARYL)GUANIDINES FROM ELECTRON-DEFICIENT AMINES VIA MASKED CARBODIIMIDES
Authors: BARVIAN MR SHOWALTER HDH DOHERTY AM
Citation: Mr. Barvian et al., PREPARATION OF N,N'-BIS(ARYL)GUANIDINES FROM ELECTRON-DEFICIENT AMINES VIA MASKED CARBODIIMIDES, Tetrahedron letters, 38(39), 1997, pp. 6799-6802
TYROSINE KINASE INHIBITORS .6. STRUCTURE-ACTIVITY-RELATIONSHIPS AMONGN-SUBSTITUTED AND 3-SUBSTITUTED 2,2'-DISELENOBIS(1H-INDOLES) FOR INHIBITION OF PROTEIN-TYROSINE KINASES AND COMPARATIVE IN-VITRO AND IN-VIVO STUDIES AGAINST SELECTED SULFUR CONGENERS
Authors: SHOWALTER HDH SERCEL AD LEJA BM WOLFANGEL CD AMBROSO LA ELLIOTT WL FRY DW KRAKER AJ HOWARD CT LU GH MOORE CW NELSON JM ROBERTS BJ VINCENT PW DENNY WA THOMPSON AM
Citation: Hdh. Showalter et al., TYROSINE KINASE INHIBITORS .6. STRUCTURE-ACTIVITY-RELATIONSHIPS AMONGN-SUBSTITUTED AND 3-SUBSTITUTED 2,2'-DISELENOBIS(1H-INDOLES) FOR INHIBITION OF PROTEIN-TYROSINE KINASES AND COMPARATIVE IN-VITRO AND IN-VIVO STUDIES AGAINST SELECTED SULFUR CONGENERS, Journal of medicinal chemistry, 40(4), 1997, pp. 413-426
TYROSINE KINASE INHIBITORS .13. STRUCTURE-ACTIVITY-RELATIONSHIPS FOR SOLUBLE 7-SUBSTITUTED 4-[(3-BROMOPHENYL)AMINO]PYRIDO[4,3-D]PYRIMIDINESDESIGNED AS INHIBITORS OF THE TYROSINE KINASE-ACTIVITY OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR
Authors: THOMPSON AM MURRAY DK ELLIOTT WL FRY DW NELSON JA SHOWALTER HDH ROBERTS BJ VINCENT PW DENNY WA
Citation: Am. Thompson et al., TYROSINE KINASE INHIBITORS .13. STRUCTURE-ACTIVITY-RELATIONSHIPS FOR SOLUBLE 7-SUBSTITUTED 4-[(3-BROMOPHENYL)AMINO]PYRIDO[4,3-D]PYRIMIDINESDESIGNED AS INHIBITORS OF THE TYROSINE KINASE-ACTIVITY OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR, Journal of medicinal chemistry, 40(24), 1997, pp. 3915-3925
STRUCTURE-ACTIVITY-RELATIONSHIPS FOR A NOVEL SERIES OF PYRIDO[2,3-D]PYRIMIDINE TYROSINE KINASE INHIBITORS
Authors: HAMBY JM CONNOLLY CJC SCHROEDER MC WINTERS RT SHOWALTER HDH PANEK RL MAJOR TC OLSEWSKI B RYAN MJ DAHRING T LU GH KEISER J AMAR A SHEN C KRAKER AJ SLINTAK V NELSON JM FRY DW BRADFORD L HALLAK H DOHERTY AM
Citation: Jm. Hamby et al., STRUCTURE-ACTIVITY-RELATIONSHIPS FOR A NOVEL SERIES OF PYRIDO[2,3-D]PYRIMIDINE TYROSINE KINASE INHIBITORS, Journal of medicinal chemistry, 40(15), 1997, pp. 2296-2303
TYROSINE KINASE INHIBITORS .11. SOLUBLE ANALOGS OF PYRROLOQUINAZOLINES AND PYRAZOLOQUINAZOLINES AS EPIDERMAL GROWTH-FACTOR RECEPTOR INHIBITORS - SYNTHESIS, BIOLOGICAL EVALUATION, AND MODELING OF THE MODE OF BINDING
Authors: PALMER BD TRUMPPKALLMEYER S FRY DW NELSON JM SHOWALTER HDH DENNY WA
Citation: Bd. Palmer et al., TYROSINE KINASE INHIBITORS .11. SOLUBLE ANALOGS OF PYRROLOQUINAZOLINES AND PYRAZOLOQUINAZOLINES AS EPIDERMAL GROWTH-FACTOR RECEPTOR INHIBITORS - SYNTHESIS, BIOLOGICAL EVALUATION, AND MODELING OF THE MODE OF BINDING, Journal of medicinal chemistry, 40(10), 1997, pp. 1519-1529
SYNTHESIS OF C-5 BENZOYL AND AZIDO FUNCTIONALIZED 2,2'-DITHIOBIS-(1H-INDOLE) AND 2,2'-DISELENOBIS(1H-INDOLE)
Authors: SUN L RUBIN JR KRAKER AJ SHOWALTER HDH
Citation: L. Sun et al., SYNTHESIS OF C-5 BENZOYL AND AZIDO FUNCTIONALIZED 2,2'-DITHIOBIS-(1H-INDOLE) AND 2,2'-DISELENOBIS(1H-INDOLE), Journal of heterocyclic chemistry, 34(5), 1997, pp. 1399-1405
SYNTHESIS OF 6-SUBSTITUTED PYRIDO[3,4-D]PYRIMIDIN-4(3H)-ONES VIA DIRECTED LITHIATION OF 2-SUBSTITUTED 5-AMINOPYRIDINE DERIVATIVES
Authors: REWCASTLE GW DENNY WA WINTERS RT COLBRY NL SHOWALTER HDH
Citation: Gw. Rewcastle et al., SYNTHESIS OF 6-SUBSTITUTED PYRIDO[3,4-D]PYRIMIDIN-4(3H)-ONES VIA DIRECTED LITHIATION OF 2-SUBSTITUTED 5-AMINOPYRIDINE DERIVATIVES, Journal of the Chemical Society. Perkin transactions. I, (18), 1996, pp. 2221-2226
CONCISE SYNTHESES OF THE NOVEL 1H-PYRROLO[3,2-G]QUINAZOLINE RING-SYSTEM AND ITS [2,3-F] ANGULAR ISOMER
Authors: SHOWALTER HDH SUN L SERCEL AD WINTERS RT DENNY WA PALMER BD
Citation: Hdh. Showalter et al., CONCISE SYNTHESES OF THE NOVEL 1H-PYRROLO[3,2-G]QUINAZOLINE RING-SYSTEM AND ITS [2,3-F] ANGULAR ISOMER, Journal of organic chemistry, 61(3), 1996, pp. 1155-1158
DEVELOPMENT OF A NOVEL SILYL ETHER LINKER FOR SOLID-PHASE ORGANIC-SYNTHESIS
Authors: BOEHM TL SHOWALTER HDH
Citation: Tl. Boehm et Hdh. Showalter, DEVELOPMENT OF A NOVEL SILYL ETHER LINKER FOR SOLID-PHASE ORGANIC-SYNTHESIS, Journal of organic chemistry, 61(19), 1996, pp. 6498-6499
TYROSINE KINASE INHIBITORS .9. SYNTHESIS AND EVALUATION OF FUSED TRICYCLIC QUINAZOLINE ANALOGS AS ATP SITE INHIBITORS OF THE TYROSINE KINASE-ACTIVITY OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR
Authors: REWCASTLE GW PALMER BD BRIDGES AJ SHOWALTER HDH LI S NELSON J MCMICHAEL A KRAKER AJ FRY DW DENNY WA
Citation: Gw. Rewcastle et al., TYROSINE KINASE INHIBITORS .9. SYNTHESIS AND EVALUATION OF FUSED TRICYCLIC QUINAZOLINE ANALOGS AS ATP SITE INHIBITORS OF THE TYROSINE KINASE-ACTIVITY OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR, Journal of medicinal chemistry, 39(4), 1996, pp. 918-928
TYROSINE KINASE INHIBITORS .8. AN UNUSUALLY STEEP STRUCTURE-ACTIVITY RELATIONSHIP FOR ANALOGS OF 4-(3-BROMOANILINO)-6,7-DIMETHOXYQUINAZOLINE (PD-153035), A POTENT INHIBITOR OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR
Authors: BRIDGES AJ ZHOU H CODY DR REWCASTLE GW MCMICHAEL A SHOWALTER HDH FRY DW KRAKER AJ DENNY WA
Citation: Aj. Bridges et al., TYROSINE KINASE INHIBITORS .8. AN UNUSUALLY STEEP STRUCTURE-ACTIVITY RELATIONSHIP FOR ANALOGS OF 4-(3-BROMOANILINO)-6,7-DIMETHOXYQUINAZOLINE (PD-153035), A POTENT INHIBITOR OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR, Journal of medicinal chemistry, 39(1), 1996, pp. 267-276
TYROSINE KINASE INHIBITORS .4. STRUCTURE-ACTIVITY-RELATIONSHIPS AMONGN-SUBSTITUTED AND 3-SUBSTITUTED 2,2'-DITHIOBIS(1H-INDOLES) FOR IN-VITRO INHIBITION OF RECEPTOR AND NONRECEPTOR PROTEIN-TYROSINE KINASES
Authors: PALMER BD REWCASTLE GW THOMPSON AM BOYD M SHOWALTER HDH SERCEL AD FRY DW KRAKER AJ DENNY WA
Citation: Bd. Palmer et al., TYROSINE KINASE INHIBITORS .4. STRUCTURE-ACTIVITY-RELATIONSHIPS AMONGN-SUBSTITUTED AND 3-SUBSTITUTED 2,2'-DITHIOBIS(1H-INDOLES) FOR IN-VITRO INHIBITION OF RECEPTOR AND NONRECEPTOR PROTEIN-TYROSINE KINASES, Journal of medicinal chemistry, 38(1), 1995, pp. 58-67
STRATEGIES FOR THE DISCOVERY OF NOVEL TYROSINE KINASE INHIBITORS WITHANTICANCER ACTIVITY
Authors: FRY DW KRAKER AJ CONNERS RC ELLIOTT WL NELSON JM SHOWALTER HDH LEOPOLD WR
Citation: Dw. Fry et al., STRATEGIES FOR THE DISCOVERY OF NOVEL TYROSINE KINASE INHIBITORS WITHANTICANCER ACTIVITY, Anti-cancer drug design, 9(4), 1994, pp. 331-351
SYNTHESIS, STRUCTURAL CHARACTERIZATION, AND ANTITUMOR PROPERTIES OF ANOVEL CLASS OF LARGE-RING PLATINUM(II) CHELATE COMPLEXES INCORPORATING THE CIS-1,4-DIAMINOCYCLOHEXANE LIGAND IN A UNIQUE LOCKED BOAT CONFORMATION
Authors: HOESCHELE JD SHOWALTER HDH KRAKER AJ ELLIOTT WL ROBERTS BJ KAMPF JW
Citation: Jd. Hoeschele et al., SYNTHESIS, STRUCTURAL CHARACTERIZATION, AND ANTITUMOR PROPERTIES OF ANOVEL CLASS OF LARGE-RING PLATINUM(II) CHELATE COMPLEXES INCORPORATING THE CIS-1,4-DIAMINOCYCLOHEXANE LIGAND IN A UNIQUE LOCKED BOAT CONFORMATION, Journal of medicinal chemistry, 37(17), 1994, pp. 2630-2636
ANTICANCER ANTHRAPYRAZOLES - THE SYNTHESIS OF 2-SUBSTITUTED 5-NITRO AND 5-AMINOANTHRA[1,9-CD]PYRAZOL-6(2H)-ONES
Authors: SHOWALTER HDH TURNER WR
Citation: Hdh. Showalter et Wr. Turner, ANTICANCER ANTHRAPYRAZOLES - THE SYNTHESIS OF 2-SUBSTITUTED 5-NITRO AND 5-AMINOANTHRA[1,9-CD]PYRAZOL-6(2H)-ONES, Journal of heterocyclic chemistry, 30(2), 1993, pp. 493-496
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