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Results: 1-22 |
Results: 22
TRANSPORT CHARACTERISTICS OF PEPTIDOMIMETICS - EFFECT OF THE PYRROLINONE BIOISOSTERE ON TRANSPORT ACROSS CACO-2 CELL MONOLAYERS
Authors: SUDOH M PAULETTI GM YAO WQ MOSER W YOKOYAMA A PASTERNAK A SPRENGELER PA SMITH AB HIRSCHMANN R BORCHARDT RT
Citation: M. Sudoh et al., TRANSPORT CHARACTERISTICS OF PEPTIDOMIMETICS - EFFECT OF THE PYRROLINONE BIOISOSTERE ON TRANSPORT ACROSS CACO-2 CELL MONOLAYERS, Pharmaceutical research, 15(5), 1998, pp. 719-725
SYNTHESIS OF THE FIRST TRICYCLIC HOMODETIC PEPTIDE - USE OF COORDINATED ORTHOGONAL DEPROTECTION TO ACHIEVE DIRECTED RING-CLOSURE
Authors: HIRSCHMANN R YAO WQ ARISON B MAECHLER L ROSEGAY A SPRENGELER PA SMITH AB
Citation: R. Hirschmann et al., SYNTHESIS OF THE FIRST TRICYCLIC HOMODETIC PEPTIDE - USE OF COORDINATED ORTHOGONAL DEPROTECTION TO ACHIEVE DIRECTED RING-CLOSURE, Tetrahedron, 54(25), 1998, pp. 7179-7202
MODULATION OF RECEPTOR AND RECEPTOR SUBTYPE AFFINITIES USING DIASTEREOMERIC AND ENANTIOMERIC MONOSACCHARIDE SCAFFOLDS AS A MEANS TO STRUCTURAL AND BIOLOGICAL DIVERSITY - A NEW ROUTE TO ETHER SYNTHESIS
Authors: HIRSCHMANN R HYNES J CICHYKNIGHT MA VANRIJN RD SPRENGELER PA SPOORS PG SHAKESPEARE WC PIETRANICOCOLE S BARBOSA J LIU J YAO WQ ROHRER S SMITH AB
Citation: R. Hirschmann et al., MODULATION OF RECEPTOR AND RECEPTOR SUBTYPE AFFINITIES USING DIASTEREOMERIC AND ENANTIOMERIC MONOSACCHARIDE SCAFFOLDS AS A MEANS TO STRUCTURAL AND BIOLOGICAL DIVERSITY - A NEW ROUTE TO ETHER SYNTHESIS, Journal of medicinal chemistry, 41(9), 1998, pp. 1382-1391
A 2ND-GENERATION SYNTHESIS OF SCALEMIC 3,5,5-TRISUBSTITUTED PYRROLIN-4-ONES - INCORPORATION OF FUNCTIONALIZED AMINO-ACID SIDE-CHAINS
Authors: SMITH AB BENOWITZ AB FAVOR DA SPRENGELER PA HIRSCHMANN R
Citation: Ab. Smith et al., A 2ND-GENERATION SYNTHESIS OF SCALEMIC 3,5,5-TRISUBSTITUTED PYRROLIN-4-ONES - INCORPORATION OF FUNCTIONALIZED AMINO-ACID SIDE-CHAINS, Tetrahedron letters, 38(22), 1997, pp. 3809-3812
AN ORALLY BIOAVAILABLE PYRROLINONE INHIBITOR OF HIV-1 PROTEASE - COMPUTATIONAL ANALYSIS AND X-RAY CRYSTAL-STRUCTURE OF THE ENZYME COMPLEX
Authors: SMITH AB HIRSCHMANN R PASTERNAK A YAO WQ SPRENGELER PA HOLLOWAY MK KUO LC CHEN ZG DARKE PL SCHLEIF WA
Citation: Ab. Smith et al., AN ORALLY BIOAVAILABLE PYRROLINONE INHIBITOR OF HIV-1 PROTEASE - COMPUTATIONAL ANALYSIS AND X-RAY CRYSTAL-STRUCTURE OF THE ENZYME COMPLEX, Journal of medicinal chemistry, 40(16), 1997, pp. 2440-2444
RELATIVE AND ABSOLUTE STEREOCHEMISTRIES AND TOTAL SYNTHESIS OF (-MACROSPHELIDE-A AND (+)-MACROSPHELIDE-B, POTENT, ORALLY BIOAVAILABLE INHIBITORS OF CELL-CELL ADHESION())
Authors: SUNAZUKA T HIROSE T HARIGAYA Y TAKAMATSU S HAYASHI M KOMIYAMA K OMURA S SPRENGELER PA SMITH AB
Citation: T. Sunazuka et al., RELATIVE AND ABSOLUTE STEREOCHEMISTRIES AND TOTAL SYNTHESIS OF (-MACROSPHELIDE-A AND (+)-MACROSPHELIDE-B, POTENT, ORALLY BIOAVAILABLE INHIBITORS OF CELL-CELL ADHESION()), Journal of the American Chemical Society, 119(42), 1997, pp. 10247-10248
PHOSPHONATE DIESTER AND PHOSPHONAMIDE SYNTHESIS - REACTION COORDINATEANALYSIS BY P-31 NMR-SPECTROSCOPY - IDENTIFICATION OF PYROPHOSPHONATEANHYDRIDES AND HIGHLY REACTIVE PHOSPHONYLAMMONIUM SALTS
Authors: HIRSCHMANN R YAGER KM TAYLOR CM WITHERINGTON J SPRENGELER PA PHILLIPS BW MOORE W SMITH AB
Citation: R. Hirschmann et al., PHOSPHONATE DIESTER AND PHOSPHONAMIDE SYNTHESIS - REACTION COORDINATEANALYSIS BY P-31 NMR-SPECTROSCOPY - IDENTIFICATION OF PYROPHOSPHONATEANHYDRIDES AND HIGHLY REACTIVE PHOSPHONYLAMMONIUM SALTS, Journal of the American Chemical Society, 119(35), 1997, pp. 8177-8190
INVESTIGATIONS OF AN ANTIBODY LIGASE
Authors: SMITHRUD DB BENKOVIC PA BENKOVIC SJ TAYLOR CM YAGER KM WITHERINGTON J PHILIPS BW SPRENGELER PA SMITH AB HIRSCHMANN R
Citation: Db. Smithrud et al., INVESTIGATIONS OF AN ANTIBODY LIGASE, Journal of the American Chemical Society, 119(2), 1997, pp. 278-282
THE FIRST SYNTHESIS OF A TRICYCLIC HOMODETIC PEPTIDE EMPLOYING COORDINATED ORTHOGONAL PROTECTION
Authors: HIRSCHMANN R YAO WQ ARISON B MAECHLER L SPRENGELER PA SMITH AB
Citation: R. Hirschmann et al., THE FIRST SYNTHESIS OF A TRICYCLIC HOMODETIC PEPTIDE EMPLOYING COORDINATED ORTHOGONAL PROTECTION, Tetrahedron letters, 37(32), 1996, pp. 5637-5640
SYNTHESIS OF POTENT CYCLIC HEXAPEPTIDE NK-1 ANTAGONISTS - USE OF A MINILIBRARY IN TRANSFORMING A PEPTIDAL SOMATOSTATIN RECEPTOR-LIGAND INTOAN NK-1 RECEPTOR-LIGAND VIA A POLYVALENT PEPTIDOMIMETIC
Authors: HIRSCHMANN R YAO WQ CASCIERI MA STRADER CD MAECHLER L CICHYKNIGHT MA HYNES J VANRIJN RD SPRENGELER PA SMITH AB
Citation: R. Hirschmann et al., SYNTHESIS OF POTENT CYCLIC HEXAPEPTIDE NK-1 ANTAGONISTS - USE OF A MINILIBRARY IN TRANSFORMING A PEPTIDAL SOMATOSTATIN RECEPTOR-LIGAND INTOAN NK-1 RECEPTOR-LIGAND VIA A POLYVALENT PEPTIDOMIMETIC, Journal of medicinal chemistry, 39(13), 1996, pp. 2441-2448
STEREOSTRUCTURE OF (-)-CHLOROPEPTIN-I, A NOVEL INHIBITOR OF GP120-CD4BINDING, VIA HIGH-TEMPERATURE MOLECULAR-DYNAMICS, MONTE-CARLO CONFORMATIONAL SEARCHING, AND NMR-SPECTROSCOPY
Authors: GOUDA H MATSUZAKI K TANAKA H HIRONO S OMURA S MCCAULEY JA SPRENGELER PA FURST GT SMITH AB
Citation: H. Gouda et al., STEREOSTRUCTURE OF (-)-CHLOROPEPTIN-I, A NOVEL INHIBITOR OF GP120-CD4BINDING, VIA HIGH-TEMPERATURE MOLECULAR-DYNAMICS, MONTE-CARLO CONFORMATIONAL SEARCHING, AND NMR-SPECTROSCOPY, Journal of the American Chemical Society, 118(51), 1996, pp. 13087-13088
TOTAL SYNTHESIS OF (+)-LACTACYSTIN
Authors: NAGAMITSU T SUNAZUKA T TANAKA H OMURA S SPRENGELER PA SMITH AB
Citation: T. Nagamitsu et al., TOTAL SYNTHESIS OF (+)-LACTACYSTIN, Journal of the American Chemical Society, 118(15), 1996, pp. 3584-3590
TREMORGENIC INDOLE ALKALOIDS .9. ASYMMETRIC CONSTRUCTION OF AN ADVANCED F-G-H-RING LACTONE PRECURSOR FOR THE SYNTHESIS OF PENITREM-D
Authors: SMITH AB NOLEN EG SHIRAI R BLASE FR OHTA M CHIDA N HARTZ RA FITCH DM CLARK WM SPRENGELER PA
Citation: Ab. Smith et al., TREMORGENIC INDOLE ALKALOIDS .9. ASYMMETRIC CONSTRUCTION OF AN ADVANCED F-G-H-RING LACTONE PRECURSOR FOR THE SYNTHESIS OF PENITREM-D, Journal of organic chemistry, 60(24), 1995, pp. 7837-7848
DESIGN AND SYNTHESIS OF NONPEPTIDE PEPTIDOMIMETIC INHIBITORS OF RENIN
Authors: SMITH AB AKAISHI R JONES DR KEENAN TP GUZMAN MC HOLCOMB RC SPRENGELER PA WOOD JL HIRSCHMANN R HOLLOWAY MK
Citation: Ab. Smith et al., DESIGN AND SYNTHESIS OF NONPEPTIDE PEPTIDOMIMETIC INHIBITORS OF RENIN, Biopolymers, 37(1), 1995, pp. 29-53
PYRROLINONE-BASED HIV PROTEASE INHIBITORS - DESIGN, SYNTHESIS, AND ANTIVIRAL ACTIVITY - EVIDENCE FOR IMPROVED TRANSPORT
Authors: SMITH AB HIRSCHMANN R PASTERNAK A GUZMAN MC YOKOYAMA A SPRENGELER PA DARKE PL EMINI EA SCHLEIF WA
Citation: Ab. Smith et al., PYRROLINONE-BASED HIV PROTEASE INHIBITORS - DESIGN, SYNTHESIS, AND ANTIVIRAL ACTIVITY - EVIDENCE FOR IMPROVED TRANSPORT, Journal of the American Chemical Society, 117(45), 1995, pp. 11113-11123
PHOSPHONYLTRIETHYLAMMONIUM SALTS - NOVEL REACTIVE SPECIES FOR THE SYNTHESIS OF PHOSPHONATE ESTERS AND PHOSPHONAMIDES
Authors: HIRSCHMANN R YAGER KM TAYLOR CM MOORE W SPRENGELER PA WITHERINGTON J PHILLIPS BW SMITH AB
Citation: R. Hirschmann et al., PHOSPHONYLTRIETHYLAMMONIUM SALTS - NOVEL REACTIVE SPECIES FOR THE SYNTHESIS OF PHOSPHONATE ESTERS AND PHOSPHONAMIDES, Journal of the American Chemical Society, 117(23), 1995, pp. 6370-6371
PEPTIDE-SYNTHESIS CATALYZED BY AN ANTIBODY CONTAINING A BINDING-SITE FOR VARIABLE AMINO-ACIDS
Authors: HIRSCHMANN R SMITH AB TAYLOR CM BENKOVIC PA TAYLOR SD YAGER KM SPRENGELER PA BENKOVIC SJ
Citation: R. Hirschmann et al., PEPTIDE-SYNTHESIS CATALYZED BY AN ANTIBODY CONTAINING A BINDING-SITE FOR VARIABLE AMINO-ACIDS, Science, 265(5169), 1994, pp. 234-237
DESIGN AND SYNTHESIS OF PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE AND RENIN - EVIDENCE FOR IMPROVED TRANSPORT
Authors: SMITH AB HIRSCHMANN R PASTERNAK A AKAISHI R GUZMAN MC JONES DR KEENAN TP SPRENGELER PA DARKE PL EMINI EA HOLLOWAY MK SCHLEIF WA
Citation: Ab. Smith et al., DESIGN AND SYNTHESIS OF PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE AND RENIN - EVIDENCE FOR IMPROVED TRANSPORT, Journal of medicinal chemistry, 37(2), 1994, pp. 215-218
DE-NOVO DESIGN, SYNTHESIS, AND X-RAY CRYSTAL-STRUCTURES OF PYRROLINONE-BASED BETA-STRAND PEPTIDOMIMETICS
Authors: SMITH AB GUZMAN MC SPRENGELER PA KEENAN TP HOLCOMB RC WOOD JL CARROLL PJ HIRSCHMANN R
Citation: Ab. Smith et al., DE-NOVO DESIGN, SYNTHESIS, AND X-RAY CRYSTAL-STRUCTURES OF PYRROLINONE-BASED BETA-STRAND PEPTIDOMIMETICS, Journal of the American Chemical Society, 116(22), 1994, pp. 9947-9962
DESIGN AND SYNTHESIS OF SULFUR-FREE CYCLIC HEXAPEPTIDES WHICH CONTAINTHE RGD SEQUENCE AND BIND TO THE FIBRINOGEN GP IIB IIIA RECEPTOR - A CONFORMATION-BASED CORRELATION BETWEEN PROPENSITY FOR IMIDE FORMATION AND RECEPTOR AFFINITY/
Authors: LENDER A YAO WQ SPRENGELER PA SPANEVELLO RA FURST GT HIRSCHMANN R SMITH AB
Citation: A. Lender et al., DESIGN AND SYNTHESIS OF SULFUR-FREE CYCLIC HEXAPEPTIDES WHICH CONTAINTHE RGD SEQUENCE AND BIND TO THE FIBRINOGEN GP IIB IIIA RECEPTOR - A CONFORMATION-BASED CORRELATION BETWEEN PROPENSITY FOR IMIDE FORMATION AND RECEPTOR AFFINITY/, International journal of peptide & protein research, 42(6), 1993, pp. 509-517
THE VERSATILE STEROID NUCLEUS - DESIGN AND SYNTHESIS OF A PEPTIDOMIMETIC EMPLOYING THIS NOVEL SCAFFOLD
Authors: HIRSCHMANN R SPRENGELER PA KAWASAKI T LEAHY JW SHAKESPEARE WC SMITH AB
Citation: R. Hirschmann et al., THE VERSATILE STEROID NUCLEUS - DESIGN AND SYNTHESIS OF A PEPTIDOMIMETIC EMPLOYING THIS NOVEL SCAFFOLD, Tetrahedron, 49(17), 1993, pp. 3665-3676
DE-NOVO DESIGN AND SYNTHESIS OF SOMATOSTATIN NONPEPTIDE PEPTIDOMIMETICS UTILIZING BETA-D-GLUCOSE AS A NOVEL SCAFFOLDING
Authors: HIRSCHMANN R NICOLAOU KC PIETRANICO S LEAHY EM SALVINO J ARISON B CICHY MA SPOORS PG SHAKESPEARE WC SPRENGELER PA HAMLEY P SMITH AB REISINE T RAYNOR K MAECHLER L DONALDSON C VALE W FREIDINGER RM CASCIERI MR STRADER CD
Citation: R. Hirschmann et al., DE-NOVO DESIGN AND SYNTHESIS OF SOMATOSTATIN NONPEPTIDE PEPTIDOMIMETICS UTILIZING BETA-D-GLUCOSE AS A NOVEL SCAFFOLDING, Journal of the American Chemical Society, 115(26), 1993, pp. 12550-12568
Risultati: 1-22 |