AAAAAA

   
Results: 1-10 |
Results: 10
The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: A binding mode for a structurally novel class of inhibitors
Authors: Chirgadze, NY Sall, DJ Briggs, SL Clawson, DK Zhang, M Smith, GF Schevitz, RW
Citation: Ny. Chirgadze et al., The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: A binding mode for a structurally novel class of inhibitors, PROTEIN SCI, 9(1), 2000, pp. 29-36
Fused bicyclic Gly-Asp beta-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere
Authors: Fisher, MJ Giese, U Harms, CS Kinnick, MD Lindstrom, TD McCowan, JR Mest, HJ Morin, JM Mullaney, JT Paal, M Rapp, A Ruhter, G Ruterbories, KJ Sall, DJ Scarborough, RM Schotten, T Stenzel, W Towner, RD Um, SL Utterback, BG Wyss, VL Jakubowski, JA
Citation: Mj. Fisher et al., Fused bicyclic Gly-Asp beta-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere, BIOORG MED, 10(4), 2000, pp. 385-389
1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: A novel series of thrombin inhibitors
Authors: Takeuchi, K Bastian, JA Gifford-Moore, DS Harper, RW Miller, SC Mullaney, JT Sall, DJ Smith, GF Zhang, MS Fisher, MJ
Citation: K. Takeuchi et al., 1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: A novel series of thrombin inhibitors, BIOORG MED, 10(20), 2000, pp. 2347-2351
Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. Part 6: Further focus on the contracted C4 '-sidechain analogues
Authors: Takeuchi, K Kohn, TJ Harper, RW Lin, HS Gifford-Moore, DS Richett, ME Sall, DJ Smith, GF Zhang, MS
Citation: K. Takeuchi et al., Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. Part 6: Further focus on the contracted C4 '-sidechain analogues, BIOORG MED, 10(11), 2000, pp. 1199-1202
Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 5. Potency, efficacy, and pharmacokinetic properties of modified C-3 side chain derivatives
Authors: Sall, DJ Bailey, DL Bastian, JA Buben, JA Chirgadze, NY Clemens-Smith, AC Denney, ML Fisher, MJ Giera, DD Gifford-Moore, DS Harper, RW Johnson, LM Klimkowski, VJ Kohn, TJ Lin, HS McCowan, JR Palkowitz, AD Richett, ME Smith, GF Snyder, DW Takeuchi, K Toth, JE Zhang, MS
Citation: Dj. Sall et al., Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 5. Potency, efficacy, and pharmacokinetic properties of modified C-3 side chain derivatives, J MED CHEM, 43(4), 2000, pp. 649-663
Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restrictedC3-side chain of hydroxybenzo[b]thiophenes
Authors: Takeuchi, K Kohn, TJ Sall, DJ Denney, ML McCowan, JR Smith, GF Gifford-Moore, DS
Citation: K. Takeuchi et al., Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restrictedC3-side chain of hydroxybenzo[b]thiophenes, BIOORG MED, 9(5), 1999, pp. 759-764
Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of invivo efficacy
Authors: Zhang, MS Bailey, DL Bastian, JA Briggs, SL Chirgadze, NY Clawson, DK Denney, ML Gifford-Moore, DS Harper, RW Johnson, LM Klimkowski, VJ Kohn, TJ Lin, HS McCowan, JR Richett, ME Sall, DJ Smith, AJ Smith, GF Snyder, DW Takeuchi, K Utterback, BG Yan, SCB
Citation: Ms. Zhang et al., Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of invivo efficacy, BIOORG MED, 9(5), 1999, pp. 775-780
Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4" side chain
Authors: Bastian, JA Chirgadze, N Denney, ML Gifford-Moore, DS Sall, DJ Smith, GF Wikel, JH
Citation: Ja. Bastian et al., Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4" side chain, BIOORG MED, 9(3), 1999, pp. 363-368
Solid phase chemistry approach to the SAR development of a novel class of active site-directed thrombin inhibitors
Authors: Johnson, MG Bronson, DD Gillespie, JE Gifford-Moore, DS Kalter, K Lynch, MP McCowan, JR Redick, CC Sall, DJ Smith, GF Foglesong, RJ
Citation: Mg. Johnson et al., Solid phase chemistry approach to the SAR development of a novel class of active site-directed thrombin inhibitors, TETRAHEDRON, 55(39), 1999, pp. 11641-11652
Fused bicyclic Gly-Asp beta-turn mimics with specific affinity for GPIIb-IIIa
Authors: Fisher, MJ Arfstan, AE Giese, U Gunn, BP Harms, CS Khau, V Kinnick, MD Lindstrom, TD Martinelli, MJ Mest, HJ Mohr, M Morin, JM Mullaney, JT Nunes, A Paal, M Rapp, A Ruhter, G Ruterbories, KJ Sall, DJ Scarborough, RM Schotten, T Sommer, B Stenzel, W Towner, RD Um, SL Utterback, BG Vasileff, RT Voelkers, S Wyss, VL Jakubowski, JA
Citation: Mj. Fisher et al., Fused bicyclic Gly-Asp beta-turn mimics with specific affinity for GPIIb-IIIa, J MED CHEM, 42(23), 1999, pp. 4875-4889
Risultati: 1-10 |