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Results: 1-15 |
Results: 15
STRUCTURE-ACTIVITY STUDIES RELATED TO ABT-594, A POTENT NONOPIOID ANALGESIC AGENT - EFFECT OF PYRIDINE AND AZETIDINE RING SUBSTITUTIONS ON NICOTINIC ACETYLCHOLINE-RECEPTOR BINDING-AFFINITY AND ANALGESIC ACTIVITY IN MICE
Authors: HOLLADAY MW BAI H LI YH LIN NH DAANEN JF RYTHER KB WASICAK JT KINCAID JF HE Y HETTINGER AM HUANG P ANDERSON DJ BANNON AW BUCKLEY MJ CAMPBELL JE DONNELLYROBERTS DL GUNTHER KL KIM DJB KUNTZWEILER TA SULLIVAN JP DECKER MW ARNERIC SP
Citation: Mw. Holladay et al., STRUCTURE-ACTIVITY STUDIES RELATED TO ABT-594, A POTENT NONOPIOID ANALGESIC AGENT - EFFECT OF PYRIDINE AND AZETIDINE RING SUBSTITUTIONS ON NICOTINIC ACETYLCHOLINE-RECEPTOR BINDING-AFFINITY AND ANALGESIC ACTIVITY IN MICE, Bioorganic & medicinal chemistry letters, 8(19), 1998, pp. 2797-2802
STUDIES ON THE PREPARATION OF PROTOMYCINOLIDE IV - ENANTIOSELECTIVE SYNTHESIS OF THE C3-C9 SEGMENT
Authors: WASICAK JT DONALDSON WA
Citation: Jt. Wasicak et Wa. Donaldson, STUDIES ON THE PREPARATION OF PROTOMYCINOLIDE IV - ENANTIOSELECTIVE SYNTHESIS OF THE C3-C9 SEGMENT, Tetrahedron : asymmetry, 9(1), 1998, pp. 133-140
ABT-594 [(R)-5-(2-AZETIDINYLMETHOXY)-2-CHLOROPYRIDINE] - A NOVEL, ORALLY EFFECTIVE ANALGESIC ACTING VIA NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS - I - IN-VITRO CHARACTERIZATION
Authors: DONNELLYROBERTS DL PUTTFARCKEN PS KUNTZWEILER TA BRIGGS CA ANDERSON DJ CAMPBELL JE PIATTONIKAPLAN M MCKENNA DG WASICAK JT HOLLADAY MW WILLIAMS M ARNERIC SP
Citation: Dl. Donnellyroberts et al., ABT-594 [(R)-5-(2-AZETIDINYLMETHOXY)-2-CHLOROPYRIDINE] - A NOVEL, ORALLY EFFECTIVE ANALGESIC ACTING VIA NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS - I - IN-VITRO CHARACTERIZATION, The Journal of pharmacology and experimental therapeutics, 285(2), 1998, pp. 777-786
ABT-594 [(R)-5-(2-AZETIDINYLMETHOXY)-2-CHLOROPYRIDINE] - A NOVEL, ORALLY EFFECTIVE ANTINOCICEPTIVE AGENT ACTING VIA NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS - II - IN-VIVO CHARACTERIZATION
Authors: BANNON AW DECKER MW CURZON P BUCKLEY MJ KIM DJB RADEK RJ LYNCH JK WASICAK JT LIN NH ARNOLD WH HOLLADAY MW WILLIAMS M ARNERIC SP
Citation: Aw. Bannon et al., ABT-594 [(R)-5-(2-AZETIDINYLMETHOXY)-2-CHLOROPYRIDINE] - A NOVEL, ORALLY EFFECTIVE ANTINOCICEPTIVE AGENT ACTING VIA NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS - II - IN-VIVO CHARACTERIZATION, The Journal of pharmacology and experimental therapeutics, 285(2), 1998, pp. 787-794
IDENTIFICATION AND INITIAL STRUCTURE-ACTIVITY-RELATIONSHIPS OF 5-(2-AZETIDINYLMETHOXY)-2-CHLOROPYRIDINE(ABT-594), A POTENT, ORALLY-ACTIVE, NONOPIATE ANALGESIC AGENT ACTING VIA NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS
Authors: HOLLADAY MW WASICAK JT LIN NH HE Y RYTHER KB BANNON AW BUCKLEY MJ KIM DJB DECKER MW ANDERSON DJ CAMPBELL JE KUNTZWEILER TA DONNELLYROBERTS DL PIATTONIKAPLAN M BRIGGS CA WILLIAMS M ARNERIC SP
Citation: Mw. Holladay et al., IDENTIFICATION AND INITIAL STRUCTURE-ACTIVITY-RELATIONSHIPS OF 5-(2-AZETIDINYLMETHOXY)-2-CHLOROPYRIDINE(ABT-594), A POTENT, ORALLY-ACTIVE, NONOPIATE ANALGESIC AGENT ACTING VIA NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS, Journal of medicinal chemistry, 41(4), 1998, pp. 407-412
ANTINOCICEPTIVE EFFECTS OF THE NOVEL NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR AGONIST, ABT-594, IN MICE
Authors: DECKER MW BANNON AW BUCKLEY MJ KIM DJB HOLLADAY MW RYTHER KB LIN NH WASICAK JT WILLIAMS M ARNERIC SP
Citation: Mw. Decker et al., ANTINOCICEPTIVE EFFECTS OF THE NOVEL NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR AGONIST, ABT-594, IN MICE, European journal of pharmacology, 346(1), 1998, pp. 23-33
ALKYLATION OF TRICARBONYL(DIENE)IRON COMPLEXES - MODEL STUDIES FOR THE PREPARATION OF PROTOMYCINOLIDE-IV
Authors: WASICAK JT CRAIG RA HENRY R DASGUPTA B LI HM DONALDSON WA
Citation: Jt. Wasicak et al., ALKYLATION OF TRICARBONYL(DIENE)IRON COMPLEXES - MODEL STUDIES FOR THE PREPARATION OF PROTOMYCINOLIDE-IV, Tetrahedron, 53(12), 1997, pp. 4185-4198
A-85380 [3-(2(S)-AZETIDINYLMETHOXY)PYRIDINE] - IN-VITRO PHARMACOLOGICAL PROPERTIES OF A NOVEL, HIGH-AFFINITY ALPHA-4-BETA-2 NICOTINIC ACETYLCHOLINE-RECEPTOR LIGAND
Authors: SULLIVAN JP DONNELLYROBERTS D BRIGGS CA ANDERSON DJ GOPALAKRISHNAN M PIATTONIKAPLAN M CAMPBELL JE MCKENNA DG MOLINARI E HETTINGER AM GARVEY DS WASICAK JT HOLLADAY MW WILLIAMS M ARNERIC SP
Citation: Jp. Sullivan et al., A-85380 [3-(2(S)-AZETIDINYLMETHOXY)PYRIDINE] - IN-VITRO PHARMACOLOGICAL PROPERTIES OF A NOVEL, HIGH-AFFINITY ALPHA-4-BETA-2 NICOTINIC ACETYLCHOLINE-RECEPTOR LIGAND, Neuropharmacology, 35(6), 1996, pp. 725-734
NOVEL 3-PYRIDYL ETHERS WITH SUBNANOMOLAR AFFINITY FOR CENTRAL NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS
Authors: ABREO MA LIN NH GARVEY DS GUNN DE HETTINGER AM WASICAK JT PAVLIK PA MARTIN YC DONNELLYROBERTS DL ANDERSON DJ SULLIVAN JP WILLIAMS M AMERIC SP HOLLADAY MW
Citation: Ma. Abreo et al., NOVEL 3-PYRIDYL ETHERS WITH SUBNANOMOLAR AFFINITY FOR CENTRAL NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS, Journal of medicinal chemistry, 39(4), 1996, pp. 817-825
SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF PYRROLIDINE-MODIFIED ANALOGS OF THE POTENT CHOLINERGIC CHANNEL ACTIVATOR, ABT-418
Authors: LIN NH HE Y ANDERSON DJ WASICAK JT KASSON R SWEENY D SULLIVAN JP
Citation: Nh. Lin et al., SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF PYRROLIDINE-MODIFIED ANALOGS OF THE POTENT CHOLINERGIC CHANNEL ACTIVATOR, ABT-418, Bioorganic & medicinal chemistry letters, 4(20), 1994, pp. 2389-2394
(S)-3-METHYL-5-(1-METHYL-2-PYRROLIDINYL)ISOXAZOLE (ABT-418) - A NOVELCHOLINERGIC LIGAND WITH COGNITION-ENHANCING AND ANXIOLYTIC ACTIVITIES.1. IN-VITRO CHARACTERIZATION
Authors: ARNERIC SP SULLIVAN JP BRIGGS CA DONNELLYROBERTS D ANDERSON DJ RASZKIEWICZ JL HUGHES ML CADMAN ED ADAMS P GARVEY DS WASICAK JT WILLIAMS M
Citation: Sp. Arneric et al., (S)-3-METHYL-5-(1-METHYL-2-PYRROLIDINYL)ISOXAZOLE (ABT-418) - A NOVELCHOLINERGIC LIGAND WITH COGNITION-ENHANCING AND ANXIOLYTIC ACTIVITIES.1. IN-VITRO CHARACTERIZATION, The Journal of pharmacology and experimental therapeutics, 270(1), 1994, pp. 310-318
(S)-3-METHYL-5-(1-METHYL-2-PYRROLIDINYL)ISOXAZOLE (ABT-418) - A NOVELCHOLINERGIC LIGAND WITH COGNITION-ENHANCING AND ANXIOLYTIC ACTIVITIES.2. IN-VIVO CHARACTERIZATION
Authors: DECKER MW BRIONI JD SULLIVAN JP BUCKLEY MJ RADEK RJ RASZKIEWICZ JL KANG CH KIM DJB GIARDINA WJ WASICAK JT GARVEY DS WILLIAMS M ARNERIC SP
Citation: Mw. Decker et al., (S)-3-METHYL-5-(1-METHYL-2-PYRROLIDINYL)ISOXAZOLE (ABT-418) - A NOVELCHOLINERGIC LIGAND WITH COGNITION-ENHANCING AND ANXIOLYTIC ACTIVITIES.2. IN-VIVO CHARACTERIZATION, The Journal of pharmacology and experimental therapeutics, 270(1), 1994, pp. 319-328
NOVEL ISOXAZOLES WHICH INTERACT WITH BRAIN CHOLINERGIC CHANNEL RECEPTORS HAVE INTRINSIC COGNITIVE ENHANCING AND ANXIOLYTIC ACTIVITIES
Authors: GARVEY DS WASICAK JT DECKER MW BRIONI JD BUCKLEY MJ SULLIVAN JP CARRERA GM HOLLADAY MW ARNERIC SP WILLIAMS M
Citation: Ds. Garvey et al., NOVEL ISOXAZOLES WHICH INTERACT WITH BRAIN CHOLINERGIC CHANNEL RECEPTORS HAVE INTRINSIC COGNITIVE ENHANCING AND ANXIOLYTIC ACTIVITIES, Journal of medicinal chemistry, 37(8), 1994, pp. 1055-1059
LIGANDS FOR BRAIN CHOLINERGIC CHANNEL RECEPTORS - SYNTHESIS AND IN-VITRO CHARACTERIZATION OF NOVEL ISOXAZOLES AND ISOTHIAZOLES AS BIOISOSTERIC REPLACEMENTS FOR THE PYRIDINE RING IN NICOTINE
Authors: GARVEY DS WASICAK JT ELLIOTT RL LEBOLD SA HETTINGER AM CARRERA GM LIN NH HE Y HOLLADAY MW ANDERSON DJ CADMAN ED RASZKIEWICZ JL SULLIVAN JP ARNERIC SP
Citation: Ds. Garvey et al., LIGANDS FOR BRAIN CHOLINERGIC CHANNEL RECEPTORS - SYNTHESIS AND IN-VITRO CHARACTERIZATION OF NOVEL ISOXAZOLES AND ISOTHIAZOLES AS BIOISOSTERIC REPLACEMENTS FOR THE PYRIDINE RING IN NICOTINE, Journal of medicinal chemistry, 37(26), 1994, pp. 4455-4463
CONFORMATIONALLY CONSTRAINED AMINO-ACIDS .2. ON THE SYNTHESIS OF 4-SUBSTITUTED 8-MEMBERED CYCLIC TRYPTOPHAN DERIVATIVES
Authors: CHUNG JYL WASICAK JT NADZAN AM
Citation: Jyl. Chung et al., CONFORMATIONALLY CONSTRAINED AMINO-ACIDS .2. ON THE SYNTHESIS OF 4-SUBSTITUTED 8-MEMBERED CYCLIC TRYPTOPHAN DERIVATIVES, Synthetic communications, 22(7), 1992, pp. 1039-1048
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