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Results: 1-25 | 26-35
Results: 1-25/35
PYRAZOLES, 1,2,4-TRIAZOLES, AND TETRAZOLES AS SURROGATES FOR CIS-AMIDE BONDS IN BORONATE ESTER THROMBIN INHIBITORS
Authors: DUNCIA JV SANTELLA JB HIGLEY CA VANATTEN MK WEBER PC ALEXANDER RS KETTNER CA PRUITT JR LIAUW AY QUAN ML KNABB RM WEXLER RR
Citation: Jv. Duncia et al., PYRAZOLES, 1,2,4-TRIAZOLES, AND TETRAZOLES AS SURROGATES FOR CIS-AMIDE BONDS IN BORONATE ESTER THROMBIN INHIBITORS, Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 775-780
RATIONAL DESIGN OF BOROPEPTIDE THROMBIN INHIBITORS - BETA,BETA-DIALKYLPHENETHYLGLYCINE P2 ANALOGS OF DUP-714 WITH GREATER SELECTIVITY OVER COMPLEMENT FACTOR-I AND AN IMPROVED SAFETY PROFILE
Authors: FEVIG JM BURIAK J CACCIOLA J ALEXANDER RS KETTNER CA KNABB RM PRUITT JR WEBER PC WEXLER RR
Citation: Jm. Fevig et al., RATIONAL DESIGN OF BOROPEPTIDE THROMBIN INHIBITORS - BETA,BETA-DIALKYLPHENETHYLGLYCINE P2 ANALOGS OF DUP-714 WITH GREATER SELECTIVITY OVER COMPLEMENT FACTOR-I AND AN IMPROVED SAFETY PROFILE, Bioorganic & medicinal chemistry letters, 8(3), 1998, pp. 301-306
MEK INHIBITORS - THE CHEMISTRY AND BIOLOGICAL-ACTIVITY OF U0126, ITS ANALOGS, AND CYCLIZATION PRODUCTS
Authors: DUNCIA JV SANTELLA JB HIGLEY CA PITTS WJ WITYAK J FRIETZE WE RANKIN FW SUN JH EARL RA TABAKA AC TELEHA CA BLOM KF FAVATA MF MANOS EJ DAULERIO AJ STRADLEY DA HORIUCHI K COPELAND RA SCHERLE PA TRZASKOS JM MAGOLDA RL TRAINOR GL WEXLER RR HOBBS FW OLSON RE
Citation: Jv. Duncia et al., MEK INHIBITORS - THE CHEMISTRY AND BIOLOGICAL-ACTIVITY OF U0126, ITS ANALOGS, AND CYCLIZATION PRODUCTS, Bioorganic & medicinal chemistry letters, 8(20), 1998, pp. 2839-2844
THE DE-NOVO DESIGN AND SYNTHESIS OF CYCLIC UREA INHIBITORS OF FACTOR XA - INITIAL SAR STUDIES
Authors: GALEMMO RA MADUSKUIE TP DOMINGUEZ C ROSSI KA KNABB RM WEXLER RR STOUTEN PFW
Citation: Ra. Galemmo et al., THE DE-NOVO DESIGN AND SYNTHESIS OF CYCLIC UREA INHIBITORS OF FACTOR XA - INITIAL SAR STUDIES, Bioorganic & medicinal chemistry letters, 8(19), 1998, pp. 2705-2710
ORAL ANTIPLATELET EFFICACY AND SPECIFICITY OF A NOVEL NONPEPTIDE PLATELET GPIIB IIIA RECEPTOR ANTAGONIST, DMP-802/
Authors: MOUSA SA OLSON RE BOZARTH JM LORELLI W FORSYTHE MS RACANELLI A GIBBS S SCHLINGMAN K BOZARTH T KAPIL R WITYAK J SIELECKI TM WEXLER RR THOOLEN MJ SLEE A REILLY TM ANDERSON PS FRIEDMAN PA
Citation: Sa. Mousa et al., ORAL ANTIPLATELET EFFICACY AND SPECIFICITY OF A NOVEL NONPEPTIDE PLATELET GPIIB IIIA RECEPTOR ANTAGONIST, DMP-802/, Journal of cardiovascular pharmacology, 32(2), 1998, pp. 169-176
BISBENZAMIDINE ISOXAZOLINE DERIVATIVES AS FACTOR XA INHIBITORS
Authors: QUAN ML PRUITT JR ELLIS CD LIAUW AY GALEMMO RA STOUTEN PFW WITYAK J KNABB RM THOOLEN MJ WONG PC WEXLER RR
Citation: Ml. Quan et al., BISBENZAMIDINE ISOXAZOLINE DERIVATIVES AS FACTOR XA INHIBITORS, Bioorganic & medicinal chemistry letters, 7(21), 1997, pp. 2813-2818
BIARYL SUBSTITUTED ALKYLBORONATE ESTERS AS THROMBIN INHIBITORS
Authors: QUAN ML WITYAK J DOMINGUEZ C DUNCIA JV KETTNER CA ELLIS CD LIAUW AY PARK JM SANTELLA JB KNABB RM THOOLEN MJ WEBER PC WEXLER RR
Citation: Ml. Quan et al., BIARYL SUBSTITUTED ALKYLBORONATE ESTERS AS THROMBIN INHIBITORS, Bioorganic & medicinal chemistry letters, 7(13), 1997, pp. 1595-1600
S-1 HETEROCYCLIC THROMBIN INHIBITORS
Authors: DOMINGUEZ C CARINI DJ WEBER PC KNABB RM ALEXANDER RS KETTNER CA WEXLER RR
Citation: C. Dominguez et al., S-1 HETEROCYCLIC THROMBIN INHIBITORS, Bioorganic & medicinal chemistry letters, 7(1), 1997, pp. 79-84
ANTIPLATELET EFFICACY OF ORALLY-ADMINISTERED DMP802, A GPIIB IIIA RECEPTOR ANTAGONIST, IN THE CONSCIOUS DOG/
Authors: REILLY TM RACANELLI AL OLSON RE WITYAK J WEXLER RR HAUSNER EA THOOLEN MJ MOUSA SA
Citation: Tm. Reilly et al., ANTIPLATELET EFFICACY OF ORALLY-ADMINISTERED DMP802, A GPIIB IIIA RECEPTOR ANTAGONIST, IN THE CONSCIOUS DOG/, Journal of the American College of Cardiology, 29(2), 1997, pp. 7122-7122
THE DISCOVERY OF POTENT ISOXAZOLINE GLYCOPROTEIN-IIB IIIA RECEPTOR ANTAGONISTS. (VOL 40, PG 53, 1997)/
Authors: WITYAK J SIELECKI TM PINTO DJ EMMETT G SZE JY LIU J TOBIN AE WANG SG JIANG B MA P MOUSA SA OLSON RE WEXLER RR
Citation: J. Wityak et al., THE DISCOVERY OF POTENT ISOXAZOLINE GLYCOPROTEIN-IIB IIIA RECEPTOR ANTAGONISTS. (VOL 40, PG 53, 1997)/, Journal of medicinal chemistry, 40(8), 1997, pp. 1292-1292
DISCOVERY OF AN ORALLY-ACTIVE SERIES OF ISOXAZOLINE GLYCOPROTEIN IIB IIIA ANTAGONISTS/
Authors: XUE CB WITYAK J SIELECKI TM PINTO DJ BATT DG CAIN GA SWORIN M ROCKWELL AL RODERICK JJ WANG SG ORWAT MJ FRIETZE WE BOSTROM LL LIU J HIGLEY CA RANKIN FW TOBIN AE EMMETT G LALKA GK SZE JY DIMEO SV MOUSA SA THOOLEN MJ RACANELLI AL HAUSNER EA REILLY TM DEGRADO WF WEXLER RR OLSON RE
Citation: Cb. Xue et al., DISCOVERY OF AN ORALLY-ACTIVE SERIES OF ISOXAZOLINE GLYCOPROTEIN IIB IIIA ANTAGONISTS/, Journal of medicinal chemistry, 40(13), 1997, pp. 2064-2084
DISCOVERY OF POTENT ISOXAZOLINE GLYCOPROTEIN IIB IIIA RECEPTOR ANTAGONISTS/
Authors: WITYAK J SIELECKI TM PINTO DJ EMMETT G SZE JY LIU J TOBIN AE WANG SA JIANG B MA P MOUSA SA WEXLER RR OLSON RE
Citation: J. Wityak et al., DISCOVERY OF POTENT ISOXAZOLINE GLYCOPROTEIN IIB IIIA RECEPTOR ANTAGONISTS/, Journal of medicinal chemistry, 40(1), 1997, pp. 50-60
(N-ACYL-N-ALKYL)GLYCYL BOROLYSINE ANALOGS - A NEW CLASS OF POTENT THROMBIN INHIBITORS
Authors: GALEMMO RA FEVIG JM CARINI DJ CACCIOLA J WELLS BL HILLYER GL BURIAK J ROSSI KA STOUTEN PFW ALEXANDER RS HILMER R BOSTROM L ABELMAN MM LEE SL WEBER PC KETTNER CA KNABB RM WEXLER RR
Citation: Ra. Galemmo et al., (N-ACYL-N-ALKYL)GLYCYL BOROLYSINE ANALOGS - A NEW CLASS OF POTENT THROMBIN INHIBITORS, Bioorganic & medicinal chemistry letters, 6(24), 1996, pp. 2913-2918
NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - THE NEXT-GENERATION IN ANTIHYPERTENSIVE THERAPY
Authors: WEXLER RR GREENLEE WJ IRVIN JD GOLDBERG MR PRENDERGAST K SMITH RD TIMMERMANS PBMWM
Citation: Rr. Wexler et al., NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - THE NEXT-GENERATION IN ANTIHYPERTENSIVE THERAPY, Journal of medicinal chemistry, 39(3), 1996, pp. 625-656
PHARMACOLOGY AND PHARMACOKINETICS OF A NOVEL NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONIST - DMP-811
Authors: WONG PC HUANG SM ARDECKY RJ CARINI DJ CHIU AT PRICE WA AGRA AM WEXLER RR TIMMERMANS PBMWM
Citation: Pc. Wong et al., PHARMACOLOGY AND PHARMACOKINETICS OF A NOVEL NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONIST - DMP-811, Clinical and experimental hypertension, 17(8), 1995, pp. 1233-1256
DIBENZOBICYCLO[2.2.2.]OCTANE ANGIOTENSIN-II RECEPTOR ANTAGONISTS
Authors: DUNCIA JV SANTELLA JB CHIU AT WONG PC WEXLER RR
Citation: Jv. Duncia et al., DIBENZOBICYCLO[2.2.2.]OCTANE ANGIOTENSIN-II RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 5(3), 1995, pp. 241-246
ACYL COA-CHOLESTEROL ACYLTRANSFERASE (ACAT) INHIBITORS - UREAS BEARING HETEROCYCLIC GROUPS BIOISOSTERIC FOR AN IMIDAZOLE
Authors: WILDE RG BILLHEIMER JT GERMAIN SJ GILLIES PJ HIGLEY CA KEZAR HS MADUSKUIE TP SHIMSHICK ES WEXLER RR
Citation: Rg. Wilde et al., ACYL COA-CHOLESTEROL ACYLTRANSFERASE (ACAT) INHIBITORS - UREAS BEARING HETEROCYCLIC GROUPS BIOISOSTERIC FOR AN IMIDAZOLE, Bioorganic & medicinal chemistry letters, 5(2), 1995, pp. 167-172
ACYL-COA-CHOLESTEROL ACYLTRANSFERASE (ACAT) INHIBITORS - HETEROCYCLICBIOISOSTERES FOR THE UREA GROUP IN DUP-128
Authors: WILDE RG KLACZKIEWICZ JD BILLHEIMER JT WEXLER RR GILLIES PJ
Citation: Rg. Wilde et al., ACYL-COA-CHOLESTEROL ACYLTRANSFERASE (ACAT) INHIBITORS - HETEROCYCLICBIOISOSTERES FOR THE UREA GROUP IN DUP-128, Bioorganic & medicinal chemistry letters, 5(2), 1995, pp. 177-180
SYNTHESIS AND ANTIPLATELET ACTIVITY OF DMP-757 ANALOGS
Authors: WITYAK J FEVIG JM JACKSON SA JOHNSON AL MOUSA SA PARTHASARATHY A WELLS GJ DEGRADO WF WEXLER RR
Citation: J. Wityak et al., SYNTHESIS AND ANTIPLATELET ACTIVITY OF DMP-757 ANALOGS, Bioorganic & medicinal chemistry letters, 5(18), 1995, pp. 2097-2100
DISCOVERY OF LOSARTAN, THE FIRST ANGIOTENSIN-II RECEPTOR ANTAGONIST
Authors: TIMMERMANS PBMWM DUNCIA JV CARINI DJ CHIU AT WONG PC WEXLER RR SMITH RD
Citation: Pbmwm. Timmermans et al., DISCOVERY OF LOSARTAN, THE FIRST ANGIOTENSIN-II RECEPTOR ANTAGONIST, Journal of human hypertension, 9, 1995, pp. 3-18
PHARMACOLOGY OF XR510, A POTENT ORALLY-ACTIVE NONPEPTIDE ANGIOTENSIN-II AT(1) RECEPTOR ANTAGONIST WITH HIGH-AFFINITY FOR THE AT(2) RECEPTORSUBTYPE
Authors: WONG PC QUAN ML SAYE JM BERNARD R CRAIN EJ MCCALL DE WATSON CA ZASPEL AM SMITH RD WEXLER RR TIMMERMANS PBMWM CHIU AT
Citation: Pc. Wong et al., PHARMACOLOGY OF XR510, A POTENT ORALLY-ACTIVE NONPEPTIDE ANGIOTENSIN-II AT(1) RECEPTOR ANTAGONIST WITH HIGH-AFFINITY FOR THE AT(2) RECEPTORSUBTYPE, Journal of cardiovascular pharmacology, 26(3), 1995, pp. 354-362
DESIGN, SYNTHESIS, AND STRUCTURE-ACTIVITY RELATIONSHIP STUDIES FOR A NEW IMIDAZOLE SERIES OF J774 MACROPHAGE SPECIFIC ACYL-COA-CHOLESTEROL ACYLTRANSFERASE (ACAT) INHIBITORS
Authors: MADUSKUIE TP WILDE RG BILLHEIMER JT CROMLEY DA GERMAIN S GILLIES PJ HIGLEY CA JOHNSON AL PENNEV P SHIMSHICK EJ WEXLER RR
Citation: Tp. Maduskuie et al., DESIGN, SYNTHESIS, AND STRUCTURE-ACTIVITY RELATIONSHIP STUDIES FOR A NEW IMIDAZOLE SERIES OF J774 MACROPHAGE SPECIFIC ACYL-COA-CHOLESTEROL ACYLTRANSFERASE (ACAT) INHIBITORS, Journal of medicinal chemistry, 38(7), 1995, pp. 1067-1083
BALANCED AT(1) AT(2) RECEPTOR ANTAGONISTS .4. XR510 AND RELATED 5-(3-AMIDOPROPANOYL)IMIDAZOLES POSSESSING EQUAL AFFINITY FOR THE AT(1) AND AT(2) RECEPTORS/
Authors: QUAN ML CHIU AT ELLIS CD WONG PC WEXLER RR TIMMERMANS PBMWM
Citation: Ml. Quan et al., BALANCED AT(1) AT(2) RECEPTOR ANTAGONISTS .4. XR510 AND RELATED 5-(3-AMIDOPROPANOYL)IMIDAZOLES POSSESSING EQUAL AFFINITY FOR THE AT(1) AND AT(2) RECEPTORS/, Journal of medicinal chemistry, 38(15), 1995, pp. 2938-2945
BALANCED ANGIOTENSIN-II RECEPTOR ANTAGONISTS .2. 4-AMINOMETHYLIMIDAZOLES AND ACYLAMINOMETHYLIMIDAZOLES
Authors: OLSON RE LIU J LALKA GK VANATTEN MK WEXLER RR CHIU AT NGUYEN TT MCCALL DE WONG PC TIMMERMANS PBMWM
Citation: Re. Olson et al., BALANCED ANGIOTENSIN-II RECEPTOR ANTAGONISTS .2. 4-AMINOMETHYLIMIDAZOLES AND ACYLAMINOMETHYLIMIDAZOLES, Bioorganic & medicinal chemistry letters, 4(18), 1994, pp. 2229-2234
BALANCED ANGIOTENSIN-II RECEPTOR ANTAGONISTS .3. THE EFFECTS OF SUBSTITUTION AT THE IMIDAZOLE 5-POSITION
Authors: SANTELLA JB DUNCIA JV ENSINGER CL VANATTEN MK CARINI DJ WEXLER RR CHIU AT WONG PC TIMMERMANS PBMWM
Citation: Jb. Santella et al., BALANCED ANGIOTENSIN-II RECEPTOR ANTAGONISTS .3. THE EFFECTS OF SUBSTITUTION AT THE IMIDAZOLE 5-POSITION, Bioorganic & medicinal chemistry letters, 4(18), 1994, pp. 2235-2240
Risultati: 1-25 | 26-35