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Results: 1-25 | 26-30
Results: 1-25/30
IDENTIFICATION OF POTENT INHIBITORS OF PLASMODIUM-FALCIPARUM PLASMEPSIN-II FROM AN ENCODED STATINE COMBINATORIAL LIBRARY
Authors: CARROLL CD PATEL H JOHNSON TO GUO T ORLOWSKI M HE ZM CAVALLARO CL GUO J OKSMAN A GLUZMAN IY CONNELLY J CHELSKY D GOLDBERG DE DOLLE RE
Citation: Cd. Carroll et al., IDENTIFICATION OF POTENT INHIBITORS OF PLASMODIUM-FALCIPARUM PLASMEPSIN-II FROM AN ENCODED STATINE COMBINATORIAL LIBRARY, Bioorganic & medicinal chemistry letters, 8(17), 1998, pp. 2315-2320
ATP-CITRATE LYASE AS A TARGET FOR HYPOLIPIDEMIC INTERVENTION - 2 - SYNTHESIS AND EVALUATION OF -OMEGA-SUBSTITUTED-3-CARBOXY-3,5-DIHYDROXYALKANOIC ACIDS AND THEIR GAMMA-LACTONE PRODRUGS AS INHIBITORS OF THE ENZYME IN-VITRO AND IN-VIVO
Authors: GRIBBLE AD IFE RJ SHAW A MCNAIR D NOVELLI CE BAKEWELL S SHAH VP DOLLE RE GROOT PH PEARCE N YATES J TEW D BOYD H ASHMAN S EGGLESTON DS HALTIWANGER RC OKAFO G
Citation: Ad. Gribble et al., ATP-CITRATE LYASE AS A TARGET FOR HYPOLIPIDEMIC INTERVENTION - 2 - SYNTHESIS AND EVALUATION OF -OMEGA-SUBSTITUTED-3-CARBOXY-3,5-DIHYDROXYALKANOIC ACIDS AND THEIR GAMMA-LACTONE PRODRUGS AS INHIBITORS OF THE ENZYME IN-VITRO AND IN-VIVO, Journal of medicinal chemistry, 41(19), 1998, pp. 3582-3595
DISCOVERY OF ENZYME-INHIBITORS THROUGH COMBINATORIAL CHEMISTRY
Authors: DOLLE RE
Citation: Re. Dolle, DISCOVERY OF ENZYME-INHIBITORS THROUGH COMBINATORIAL CHEMISTRY, Molecular diversity, 2(4), 1997, pp. 223-236
3-CHLORO-4-CARBOXAMIDO-6-ARYLPYRIDAZINES AS A NONPEPTIDE CLASS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME-INHIBITOR
Authors: DOLLE RE HOYER D RINKER JM ROSS TM SCHMIDT SJ HELASZEK CT ATOR MA
Citation: Re. Dolle et al., 3-CHLORO-4-CARBOXAMIDO-6-ARYLPYRIDAZINES AS A NONPEPTIDE CLASS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME-INHIBITOR, Bioorganic & medicinal chemistry letters, 7(8), 1997, pp. 1003-1006
ALPHA-((TETRONOYL)OXY) AND ALPHA-((TETRAMOYL)OXY)METHYL KETONE INHIBITORS OF THE INTERLEUKIN-1-BETA CONVERTING-ENZYME (ICE)
Authors: GRAYBILL TL PROUTY CP SPEIER GJ HOYER D DOLLE RE HELASZEK CT ATOR MA UHL J STRASTERS J
Citation: Tl. Graybill et al., ALPHA-((TETRONOYL)OXY) AND ALPHA-((TETRAMOYL)OXY)METHYL KETONE INHIBITORS OF THE INTERLEUKIN-1-BETA CONVERTING-ENZYME (ICE), Bioorganic & medicinal chemistry letters, 7(1), 1997, pp. 41-46
PYRIDAZINODIAZEPINES AS A HIGH-AFFINITY, P-2-P-3 PEPTIDOMIMETIC CLASSOF INTERLEUKIN-1-BETA-CONVERTING ENZYME-INHIBITOR
Authors: DOLLE RE PRASAD CVC PROUTY CP SALVINO JM AWAD MMA SCHMIDT SJ HOYER D ROSS TM GRAYBILL TL SPEIER GJ UHL J MILLER BE HELASZEK CT ATOR MA
Citation: Re. Dolle et al., PYRIDAZINODIAZEPINES AS A HIGH-AFFINITY, P-2-P-3 PEPTIDOMIMETIC CLASSOF INTERLEUKIN-1-BETA-CONVERTING ENZYME-INHIBITOR, Journal of medicinal chemistry, 40(13), 1997, pp. 1941-1946
ATP-CITRATE LYASE AS A TARGET FOR HYPOLIPIDEMIC INTERVENTION - DESIGNAND SYNTHESIS OF 2-SUBSTITUTED BUTANEDIOIC ACIDS AS NOVEL, POTENT INHIBITORS OF THE ENZYME
Authors: GRIBBLE AD DOLLE RE SHAW A MCNAIR D NOVELLI R NOVELLI CE SLINGSBY BP SHAH VP TEW D SAXTY BA ALLEN M GROOT PH PEARCE N YATES J
Citation: Ad. Gribble et al., ATP-CITRATE LYASE AS A TARGET FOR HYPOLIPIDEMIC INTERVENTION - DESIGNAND SYNTHESIS OF 2-SUBSTITUTED BUTANEDIOIC ACIDS AS NOVEL, POTENT INHIBITORS OF THE ENZYME, Journal of medicinal chemistry, 39(18), 1996, pp. 3569-3584
FIRST EXAMPLES OF PEPTIDOMIMETIC INHIBITORS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME
Authors: DOLLE RE PROUTY CP PRASAD CVC COOK E SAHA A ROSS TM SALVINO JM HELASZEK CT ATOR MA
Citation: Re. Dolle et al., FIRST EXAMPLES OF PEPTIDOMIMETIC INHIBITORS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME, Journal of medicinal chemistry, 39(13), 1996, pp. 2438-2440
PREFACE
Authors: DOLLE RE
Citation: Re. Dolle, PREFACE, Bioorganic & medicinal chemistry letters, 5(4), 1995, pp. 3-3
STRUCTURAL AND STEREOCHEMICAL REQUIREMENTS OF TIME-DEPENDENT INACTIVATORS OF THE INTERLEUKIN-1-BETA CONVERTING-ENZYME
Authors: PRASAD CVC PROUTY CP HOYER D ROSS TM SALVINO JM AWAD M GRAYBILL TL SCHMIDT SJ OSIFO IK DOLLE RE HELASZEK CT MILLER RE ATOR MA
Citation: Cvc. Prasad et al., STRUCTURAL AND STEREOCHEMICAL REQUIREMENTS OF TIME-DEPENDENT INACTIVATORS OF THE INTERLEUKIN-1-BETA CONVERTING-ENZYME, Bioorganic & medicinal chemistry letters, 5(4), 1995, pp. 315-318
CD45 PROTEIN-TYROSINE-PHOSPHATASE - DETERMINATION OF MINIMAL PEPTIDE LENGTH FOR SUBSTRATE RECOGNITION AND SYNTHESIS OF SOME TYROSINE-BASED ELECTROPHILES AS POTENTIAL ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS
Authors: BOBKO M WOLFE HR SAHA A DOLLE RE FISHER DK HIGGINS TJ
Citation: M. Bobko et al., CD45 PROTEIN-TYROSINE-PHOSPHATASE - DETERMINATION OF MINIMAL PEPTIDE LENGTH FOR SUBSTRATE RECOGNITION AND SYNTHESIS OF SOME TYROSINE-BASED ELECTROPHILES AS POTENTIAL ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS, Bioorganic & medicinal chemistry letters, 5(4), 1995, pp. 353-356
STRUCTURE-ACTIVITY-RELATIONSHIPS OF NONPEPTIDE BRADYKININ B-2 RECEPTOR ANTAGONISTS
Authors: SALVINO JM SEOANE PR DOUTY BD AWAD MA HOYER D ROSS TM DOLLE RE HOUCK WT FAUNCE DM SAWUTZ DG
Citation: Jm. Salvino et al., STRUCTURE-ACTIVITY-RELATIONSHIPS OF NONPEPTIDE BRADYKININ B-2 RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 5(4), 1995, pp. 357-362
SYNTHESIS OF NONPEPTIDE BRADYKININ B-2 RECEPTOR ANTAGONISTS
Authors: DOUTY BD SALVINO JM SEOANE PR DOLLE RE
Citation: Bd. Douty et al., SYNTHESIS OF NONPEPTIDE BRADYKININ B-2 RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 5(4), 1995, pp. 363-366
ACE-INHIBITORS AS A TEMPLATE FOR THE DESIGN OF BRADYKININ B-2 RECEPTOR ANTAGONISTS
Authors: HOYER D AWAD MMA SALVINO JM SEOANE PR DOLLE RE HOUCK WT SAWUTZ DG
Citation: D. Hoyer et al., ACE-INHIBITORS AS A TEMPLATE FOR THE DESIGN OF BRADYKININ B-2 RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 5(4), 1995, pp. 367-370
INHIBITION OF HUMAN ERYTHROCYTE CALPAIN-I BY NOVEL QUINOLINE CARBOXAMIDES
Authors: GRAYBILL TL DOLLE RE OSIFO IK SCHMIDT SJ GREGORY JS HARRIS AL MILLER MS
Citation: Tl. Graybill et al., INHIBITION OF HUMAN ERYTHROCYTE CALPAIN-I BY NOVEL QUINOLINE CARBOXAMIDES, Bioorganic & medicinal chemistry letters, 5(4), 1995, pp. 387-392
CHARACTERIZATION OF A CONTINUOUS FLUOROGENIC ASSAY FOR CALPAIN-I - KINETIC EVALUATION OF PEPTIDE ALDEHYDES, HALOMETHYL KETONES AND (ACYLOXY)METHYL KETONES AS INHIBITORS OF THE ENZYME
Authors: HARRIS AL GREGORY JS MAYCOCK AL GRAYBILL TL OSIFO IK SCHMIDT SJ DOLLE RE
Citation: Al. Harris et al., CHARACTERIZATION OF A CONTINUOUS FLUOROGENIC ASSAY FOR CALPAIN-I - KINETIC EVALUATION OF PEPTIDE ALDEHYDES, HALOMETHYL KETONES AND (ACYLOXY)METHYL KETONES AS INHIBITORS OF THE ENZYME, Bioorganic & medicinal chemistry letters, 5(4), 1995, pp. 393-398
SYNTHESIS AND EVALUATION OF DIACYLHYDRAZINES AS INHIBITORS OF THE INTERLEUKIN-1-BETA CONVERTING-ENZYME (ICE)
Authors: GRAYBILL TL DOLLE RE HELASZEK CT ATOR MA STRASTERS J
Citation: Tl. Graybill et al., SYNTHESIS AND EVALUATION OF DIACYLHYDRAZINES AS INHIBITORS OF THE INTERLEUKIN-1-BETA CONVERTING-ENZYME (ICE), Bioorganic & medicinal chemistry letters, 5(11), 1995, pp. 1197-1202
APPROACH TO THE DISCOVERY OF NOVEL, SELECTIVE INHIBITORS OF P56(LCK) TYROSINE KINASE - IDENTIFICATION OF NON-HYDROXYLATED CHROMONES AS P56(LCK) INHIBITORS
Authors: MILLER D WANG S REID J XIE W GAUVIN B KELLEY M SARUP J SAWUTZ DG MISKI M DOLLE RE FALTYNEK CR
Citation: D. Miller et al., APPROACH TO THE DISCOVERY OF NOVEL, SELECTIVE INHIBITORS OF P56(LCK) TYROSINE KINASE - IDENTIFICATION OF NON-HYDROXYLATED CHROMONES AS P56(LCK) INHIBITORS, Drug development research, 34(4), 1995, pp. 344-352
SYNTHESIS OF NOVEL THIOL-CONTAINING CITRIC-ACID ANALOGS - KINETIC EVALUATION OF THESE AND OTHER POTENTIAL ACTIVE-SITE-DIRECTED AND MECHANISM-BASED INHIBITORS OF ATP CITRATE LYASE
Authors: DOLLE RE GRIBBLE A WILKES T KRUSE LI EGGLESTON D SAXTY BA WELLS TNC GROOT PHE
Citation: Re. Dolle et al., SYNTHESIS OF NOVEL THIOL-CONTAINING CITRIC-ACID ANALOGS - KINETIC EVALUATION OF THESE AND OTHER POTENTIAL ACTIVE-SITE-DIRECTED AND MECHANISM-BASED INHIBITORS OF ATP CITRATE LYASE, Journal of medicinal chemistry, 38(3), 1995, pp. 537-543
ASPARTYL ALPHA-((DIPHENYLPHOSPHINYL)OXY)METHYL KETONES AS NOVEL INHIBITORS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME - UTILITY OF THE DIPHENYLPHOSPHINIC ACID LEAVING GROUP FOR THE INHIBITION OF CYSTEINE PROTEASES
Authors: DOLLE RE SINGH J WHIPPLE D OSIFO IK SPEIER G GRAYBILL TL GREGORY JS HARRIS AL HELASZEK CT MILLER RE ATOR MA
Citation: Re. Dolle et al., ASPARTYL ALPHA-((DIPHENYLPHOSPHINYL)OXY)METHYL KETONES AS NOVEL INHIBITORS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME - UTILITY OF THE DIPHENYLPHOSPHINIC ACID LEAVING GROUP FOR THE INHIBITION OF CYSTEINE PROTEASES, Journal of medicinal chemistry, 38(2), 1995, pp. 220-222
INHIBITION OF MATURE IL-1-BETA PRODUCTION IN MURINE MACROPHAGES AND AMURINE MODEL OF INFLAMMATION BY WIN-67694, AN INHIBITOR OF IL-1-BETA CONVERTING-ENZYME
Authors: MILLER BE KRASNEY PA GAUVIN DM HOLBROOK KB KOONZ DJ ABRUZZESE RV MILLER RE PAGANI KA DOLLE RE ATOR MA GILMAN SC
Citation: Be. Miller et al., INHIBITION OF MATURE IL-1-BETA PRODUCTION IN MURINE MACROPHAGES AND AMURINE MODEL OF INFLAMMATION BY WIN-67694, AN INHIBITOR OF IL-1-BETA CONVERTING-ENZYME, The Journal of immunology, 154(3), 1995, pp. 1331-1338
PHARMACOLOGY AND STRUCTURE ACTIVITY RELATIONSHIPS OF THE NONPEPTIDE BRADYKININ RECEPTOR ANTAGONIST WIN-64338
Authors: SAWUTZ DG SALVINO JM DOLLE RE SEOANE PR FARMER SG
Citation: Dg. Sawutz et al., PHARMACOLOGY AND STRUCTURE ACTIVITY RELATIONSHIPS OF THE NONPEPTIDE BRADYKININ RECEPTOR ANTAGONIST WIN-64338, Canadian journal of physiology and pharmacology, 73(7), 1995, pp. 805-811
PREPARATION AND EVALUATION OF PEPTIDIC ASPARTYL HEMIACETALS AS REVERSIBLE INHIBITORS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME (ICE)
Authors: GRAYBILL TL DOLLE RE HELASZEK CT MILLER RE ATOR MA
Citation: Tl. Graybill et al., PREPARATION AND EVALUATION OF PEPTIDIC ASPARTYL HEMIACETALS AS REVERSIBLE INHIBITORS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME (ICE), International journal of peptide & protein research, 44(2), 1994, pp. 173-182
THE NONPEPTIDE WIN-64338 IS A BRADYKININ B-2 RECEPTOR ANTAGONIST
Authors: SAWUTZ DG SALVINO JM DOLLE RE CASIANO F WARD SJ HOUCK WT FAUNCE DM DOUTY BD BAIZMAN E AWAD MMA MARCEAU F SEOANE PR
Citation: Dg. Sawutz et al., THE NONPEPTIDE WIN-64338 IS A BRADYKININ B-2 RECEPTOR ANTAGONIST, Proceedings of the National Academy of Sciences of the United Statesof America, 91(11), 1994, pp. 4693-4697
P-1 ASPARTATE-BASED PEPTIDE ALPHA-((2,6-DICHLOROBENZOYL)OXY)METHYL KETONES AS POTENT TIME-DEPENDENT INHIBITORS OF INTERLEUKIN-1-BETA-CONVERTING ENZYME
Authors: DOLLE RE HOYER D PRASAD CVC SCHMIDT SJ HELASZEK CT MILLER RE ATOR MA
Citation: Re. Dolle et al., P-1 ASPARTATE-BASED PEPTIDE ALPHA-((2,6-DICHLOROBENZOYL)OXY)METHYL KETONES AS POTENT TIME-DEPENDENT INHIBITORS OF INTERLEUKIN-1-BETA-CONVERTING ENZYME, Journal of medicinal chemistry, 37(5), 1994, pp. 563-564
Risultati: 1-25 | 26-30