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Results: 1-25 |
Results: 25
SULFONIMIDAMIDE ANALOGS OF ONCOLYTIC SULFONYLUREAS
Authors: TOTH JE GRINDEY GB EHLHARDT WJ RAY JE BODER GB BEWLEY JR KLINGERMAN KK GATES SB RINZEL SM SCHULTZ RM WEIR LC WORZALLA JF
Citation: Je. Toth et al., SULFONIMIDAMIDE ANALOGS OF ONCOLYTIC SULFONYLUREAS, Journal of medicinal chemistry, 40(6), 1997, pp. 1018-1025
CHARACTERIZATION OF FOLATE RECEPTOR FROM NORMAL AND NEOPLASTIC MURINETISSUE - INFLUENCE OF DIETARY-FOLATE ON FOLATE RECEPTOR EXPRESSION
Authors: GATES SB MENDELSOHN LG SHACKELFORD KA HABECK LL KURSAR JD GOSSETT LS WORZALLA JF SHIH C GRINDEY GB
Citation: Sb. Gates et al., CHARACTERIZATION OF FOLATE RECEPTOR FROM NORMAL AND NEOPLASTIC MURINETISSUE - INFLUENCE OF DIETARY-FOLATE ON FOLATE RECEPTOR EXPRESSION, Clinical cancer research, 2(7), 1996, pp. 1135-1141
SYNTHESIS AND BIOLOGICAL EVALUATION OF A NEW SERIES OF DIHYDROFOLATE-REDUCTASE INHIBITORS BASED ON THE 4-(2,6-DIAMINO-5-PYRIMIDINYL)ALKYL-L-GLUTAMIC ACID STRUCTURE
Authors: GOSSETT LS HABECK LL GATES SB ANDIS SL WORZALLA JF SCHULTZ RM MENDELSOHN LG KOHLER W RATNAM M GRINDEY GB SHIH CA
Citation: Ls. Gossett et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF A NEW SERIES OF DIHYDROFOLATE-REDUCTASE INHIBITORS BASED ON THE 4-(2,6-DIAMINO-5-PYRIMIDINYL)ALKYL-L-GLUTAMIC ACID STRUCTURE, Bioorganic & medicinal chemistry letters, 6(4), 1996, pp. 473-476
LACK OF IN-VIVO CROSSRESISTANCE WITH GEMCITABINE AGAINST DRUG-RESISTANT MURINE P388 LEUKEMIAS
Authors: WAUD WR GILBERT KS GRINDEY GB WORZALLA JF
Citation: Wr. Waud et al., LACK OF IN-VIVO CROSSRESISTANCE WITH GEMCITABINE AGAINST DRUG-RESISTANT MURINE P388 LEUKEMIAS, Cancer chemotherapy and pharmacology, 38(2), 1996, pp. 178-180
COMPARISON OF THE ANTITUMOR-ACTIVITY OF GEMCITABINE AND ARA-C IN A PANEL OF HUMAN BREAST, COLON, LUNG AND PANCREATIC XENOGRAFT MODELS
Authors: MERRIMAN RL HERTEL LW SCHULTZ RM HOUGHTON PJ HOUGHTON JA RUTHERFORD PG TANZER LR BODER GB GRINDEY GB
Citation: Rl. Merriman et al., COMPARISON OF THE ANTITUMOR-ACTIVITY OF GEMCITABINE AND ARA-C IN A PANEL OF HUMAN BREAST, COLON, LUNG AND PANCREATIC XENOGRAFT MODELS, Investigational new drugs, 14(3), 1996, pp. 243-247
AUGMENTATION OF THE THERAPEUTIC ACTIVITY OF LOMETREXOL [(6-R)5,10-DIDEAZATETRAHYDROFOLATE] BY ORAL FOLIC-ACID
Authors: ALATI T WORZALLA JF SHIH C BEWLEY JR LEWIS S MORAN RG GRINDEY GB
Citation: T. Alati et al., AUGMENTATION OF THE THERAPEUTIC ACTIVITY OF LOMETREXOL [(6-R)5,10-DIDEAZATETRAHYDROFOLATE] BY ORAL FOLIC-ACID, Cancer research, 56(10), 1996, pp. 2331-2335
DIETARY-FOLATE AND FOLYLPOLYGLUTAMATE SYNTHETASE-ACTIVITY IN NORMAL AND NEOPLASTIC MURINE TISSUES AND HUMAN TUMOR XENOGRAFTS
Authors: GATES SB WORZALLA JF SHIH C GRINDEY GB MENDELSOHN LG
Citation: Sb. Gates et al., DIETARY-FOLATE AND FOLYLPOLYGLUTAMATE SYNTHETASE-ACTIVITY IN NORMAL AND NEOPLASTIC MURINE TISSUES AND HUMAN TUMOR XENOGRAFTS, Biochemical pharmacology, 52(9), 1996, pp. 1477-1479
ROLE OF MEMBRANE-ASSOCIATED FOLATE BINDING-PROTEIN IN THE CYTOTOXICITY OF ANTIFOLATES IN KB, IGROV1, AND L1210A CELLS
Authors: SCHULTZ RM ANDIS SL SHACKELFORD KA GATES SB RATNAM M MENDELSOHN LG SHIH C GRINDEY GB
Citation: Rm. Schultz et al., ROLE OF MEMBRANE-ASSOCIATED FOLATE BINDING-PROTEIN IN THE CYTOTOXICITY OF ANTIFOLATES IN KB, IGROV1, AND L1210A CELLS, Oncology research, 7(2), 1995, pp. 97-102
TRITYLATED ONCOLYTICS AS PRODRUGS
Authors: PATEL VF HARDIN JN GRINDEY GB SCHULTZ RM
Citation: Vf. Patel et al., TRITYLATED ONCOLYTICS AS PRODRUGS, Bioorganic & medicinal chemistry letters, 5(5), 1995, pp. 513-518
EFFICACY OF SULOFENUR AND A 2ND-GENERATION DIARYLSULFONYLUREA, ROBENZOFURYL)SULFONYL]-N'-(3,4-DICHLOROPHENYL)UREA (LY295501), AGAINST COLONADENOCARCINOMA XENOGRAFTS
Authors: HOUGHTON PJ CHESHIRE PJ MYERS L LUTZ L TOTH J GRINDEY GB HOUGHTON JA
Citation: Pj. Houghton et al., EFFICACY OF SULOFENUR AND A 2ND-GENERATION DIARYLSULFONYLUREA, ROBENZOFURYL)SULFONYL]-N'-(3,4-DICHLOROPHENYL)UREA (LY295501), AGAINST COLONADENOCARCINOMA XENOGRAFTS, Anti-cancer drugs, 6(2), 1995, pp. 317-323
IN-VITRO AND IN-VIVO ANTITUMOR-ACTIVITY OF THE PHOSPHATIDYLINOSITOL-3-KINASE INHIBITOR, WORTMANNIN
Authors: SCHULTZ RM MERRIMAN RL ANDIS SL BONJOUKLIAN R GRINDEY GB RUTHERFORD PG GALLEGOS A MASSEY K POWIS G
Citation: Rm. Schultz et al., IN-VITRO AND IN-VIVO ANTITUMOR-ACTIVITY OF THE PHOSPHATIDYLINOSITOL-3-KINASE INHIBITOR, WORTMANNIN, Anticancer research, 15(4), 1995, pp. 1135-1139
MEDICINAL CHEMISTRY OF DIFLUOROPURINES
Authors: ANDIS SL BEWLEY JR BODER GB BURKE T DUDLEY DE EICHELBERGER LE GROSSMAN CS GRINDEY GB HERTEL LW JORDAN CL KROIN JS MARLOW D PATEL VF RINZEL S RUTHERFORD PG SHELF TD SEYMOUR PD SCHULTZ RM WEIR LC WORZALLA JF EHLHARDT WJ WOODLAND JM BRUNS RF ZIMMERMANN JL TODD G SARAZAN DR
Citation: Sl. Andis et al., MEDICINAL CHEMISTRY OF DIFLUOROPURINES, Seminars in oncology, 22(4), 1995, pp. 54-60
CHARACTERIZATION OF THE INTRACELLULAR-DISTRIBUTION AND BINDING IN HUMAN ADENOCARCINOMA CELLS OF N-(4-AZIDOPHENYLSULFONYL)-N'-(4-CHLOROPHENYL)UREA (LY219703), A PHOTOAFFINITY ANALOG OF THE ANTITUMOR DIARYLSULFONYLUREA SULOFENUR
Authors: HOUGHTON PJ SOSINSKI J THAKAR JH BODER GB GRINDEY GB
Citation: Pj. Houghton et al., CHARACTERIZATION OF THE INTRACELLULAR-DISTRIBUTION AND BINDING IN HUMAN ADENOCARCINOMA CELLS OF N-(4-AZIDOPHENYLSULFONYL)-N'-(4-CHLOROPHENYL)UREA (LY219703), A PHOTOAFFINITY ANALOG OF THE ANTITUMOR DIARYLSULFONYLUREA SULOFENUR, Biochemical pharmacology, 49(5), 1995, pp. 661-668
PHASE-I TRIAL OF SULOFENUR (LY186641) GIVEN ORALLY ON A DAILY X 21 SCHEDULE
Authors: BROWN TD OROURKE TJ KUHN JG CRAIG JB HAVLIN K BURRIS HA CAGNOLA J HAMILTON JM GRINDEY GB SATTERLEE WG VONHOFF DD
Citation: Td. Brown et al., PHASE-I TRIAL OF SULOFENUR (LY186641) GIVEN ORALLY ON A DAILY X 21 SCHEDULE, Anti-cancer drugs, 5(2), 1994, pp. 151-159
SYNTHESIS OF ETA-D-RIBOFURANOSYLAMINO)PYRIMIDO[5,4-D]PYRIMIDINE (DFARPP) - STABILITY AND CELLULAR CYTOTOXICITY
Authors: MABRY TE JONES CD CHOU TS COLACINO JM GRINDEY GB WORZALLA JF PEARCE HL
Citation: Te. Mabry et al., SYNTHESIS OF ETA-D-RIBOFURANOSYLAMINO)PYRIMIDO[5,4-D]PYRIMIDINE (DFARPP) - STABILITY AND CELLULAR CYTOTOXICITY, Nucleosides & nucleotides, 13(5), 1994, pp. 1125-1133
INCREASED INTRACELLULAR CA2+ SIGNALING CAUSED BY THE ANTITUMOR AGENT HELENALIN AND ITS ANALOGS
Authors: POWIS G GALLEGOS A ABRAHAM RT ASHENDEL CL ZALKOW LH GRINDEY GB BONJOUKLIAN R
Citation: G. Powis et al., INCREASED INTRACELLULAR CA2+ SIGNALING CAUSED BY THE ANTITUMOR AGENT HELENALIN AND ITS ANALOGS, Cancer chemotherapy and pharmacology, 34(4), 1994, pp. 344-350
WHOLE-BODY AUTORADIOGRAPHIC DISPOSITION AND PLASMA PHARMACOKINETICS OF 5,10-DIDEAZATETRAHYDROFOLIC ACID IN MICE FED FOLIC ACID-DEFICIENT ORREGULAR DIETS
Authors: POHLAND RC ALATI T LANTZ RJ GRINDEY GB
Citation: Rc. Pohland et al., WHOLE-BODY AUTORADIOGRAPHIC DISPOSITION AND PLASMA PHARMACOKINETICS OF 5,10-DIDEAZATETRAHYDROFOLIC ACID IN MICE FED FOLIC ACID-DEFICIENT ORREGULAR DIETS, Journal of pharmaceutical sciences, 83(10), 1994, pp. 1396-1399
NOVEL CLASS OF MONOGLUTAMATED ANTIFOLATES EXHIBITS TIGHT-BINDING INHIBITION OF HUMAN GLYCINAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE AND POTENT ACTIVITY AGAINST SOLID TUMORS
Authors: LEITNER TA SHACKELFORD KA GOSSETT LS SCHULTZ RM ANDIS SL SHIH C GRINDEY GB MENDELSOHN LG
Citation: Ta. Leitner et al., NOVEL CLASS OF MONOGLUTAMATED ANTIFOLATES EXHIBITS TIGHT-BINDING INHIBITION OF HUMAN GLYCINAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE AND POTENT ACTIVITY AGAINST SOLID TUMORS, Cancer research, 54(4), 1994, pp. 1021-1026
IMPACT OF DIETARY FOLIC-ACID ON REDUCED FOLATES IN MOUSE PLASMA AND TISSUES - RELATIONSHIP TO DIDEAZATETRAHYDROFOLATE SENSITIVITY
Authors: SCHMITZ JC GRINDEY GB SCHULTZ RM PRIEST DG
Citation: Jc. Schmitz et al., IMPACT OF DIETARY FOLIC-ACID ON REDUCED FOLATES IN MOUSE PLASMA AND TISSUES - RELATIONSHIP TO DIDEAZATETRAHYDROFOLATE SENSITIVITY, Biochemical pharmacology, 48(2), 1994, pp. 319-325
EVALUATION OF NEW ANTICANCER AGENTS AGAINST THE MIA PACA-2 AND PANC-1HUMAN PANCREATIC-CARCINOMA XENOGRAFTS
Authors: SCHULTZ RM MERRIMAN RL TOTH JE ZIMMERMANN JE HERTEL LW ANDIS SL DUDLEY DE RUTHERFORD PG TANZER LR GRINDEY GB
Citation: Rm. Schultz et al., EVALUATION OF NEW ANTICANCER AGENTS AGAINST THE MIA PACA-2 AND PANC-1HUMAN PANCREATIC-CARCINOMA XENOGRAFTS, Oncology research, 5(6-7), 1993, pp. 223-228
SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 2-DESAMINO AND 4-DEOXY ANALOGS OF 5,10-DIDEAZATETRAHYDROFOLIC ACID (DDATHF)
Authors: SHIH C HU Y GOSSETT LS HABECK LL MENDELSOHN LG GRINDEY GB
Citation: C. Shih et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 2-DESAMINO AND 4-DEOXY ANALOGS OF 5,10-DIDEAZATETRAHYDROFOLIC ACID (DDATHF), Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2657-2660
EFFECT OF ALBUMIN ON ANTITUMOR-ACTIVITY OF DIARYLSULFONYLUREAS
Authors: SCHULTZ RM ANDIS SL TOTH JE BODER GB RINZEL SM GRINDEY GB
Citation: Rm. Schultz et al., EFFECT OF ALBUMIN ON ANTITUMOR-ACTIVITY OF DIARYLSULFONYLUREAS, Anticancer research, 13(6A), 1993, pp. 1939-1943
PHARMACOKINETICS OF THE ANTICANCER AGENT SULOFENUR IN MICE, RATS, MONKEYS, AND DOGS
Authors: EHLHARDT WJ SULLIVAN HR WOOD PG WOODLAND JM HAMILTON M HAMILTON C CORNPROPST D GRINDEY GB WORZALLA JF BEWLEY JR TODD GC HOWBERT JJ
Citation: Wj. Ehlhardt et al., PHARMACOKINETICS OF THE ANTICANCER AGENT SULOFENUR IN MICE, RATS, MONKEYS, AND DOGS, Journal of pharmaceutical sciences, 82(7), 1993, pp. 683-688
EFFECT OF O6-BENZYLGUANINE ON THE SENSITIVITY OF HUMAN COLON-TUMOR XENOGRAFTS TO 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA (BCNU)
Authors: DOLAN ME PEGG AE MOSCHEL RC GRINDEY GB
Citation: Me. Dolan et al., EFFECT OF O6-BENZYLGUANINE ON THE SENSITIVITY OF HUMAN COLON-TUMOR XENOGRAFTS TO 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA (BCNU), Biochemical pharmacology, 46(2), 1993, pp. 285-290
SYNTHESIS AND BIOLOGICAL-ACTIVITY OF ACYCLIC ANALOGS OF 5,10-DIDEAZA-5,6,7,8-TETRAHYDROFOLIC ACID
Authors: SHIH C GOSSETT LS WORZALLA JF RINZEL SM GRINDEY GB HARRINGTON PM TAYLOR EC
Citation: C. Shih et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF ACYCLIC ANALOGS OF 5,10-DIDEAZA-5,6,7,8-TETRAHYDROFOLIC ACID, Journal of medicinal chemistry, 35(6), 1992, pp. 1109-1116
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