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Results: 1-25 | 26-48
Results: 1-25/48
NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS - 3 - THE SYNTHESIS OF [H-3]L-767,685 AND [H-3]L-767,679
Authors: HAMILL TG HUTCHINSON JH HARTMAN GD BURNS HD
Citation: Tg. Hamill et al., NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS - 3 - THE SYNTHESIS OF [H-3]L-767,685 AND [H-3]L-767,679, Journal of labelled compounds & radiopharmaceuticals, 41(7), 1998, pp. 677-680
NON PEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS - 2 - THE SYNTHESIS OF[H-3]L-738,167
Authors: HAMILL TG ASKEW BC HARTMAN GD CLAREMON DA MCINTYRE CJ BURNS HD
Citation: Tg. Hamill et al., NON PEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS - 2 - THE SYNTHESIS OF[H-3]L-738,167, Journal of labelled compounds & radiopharmaceuticals, 41(4), 1998, pp. 273-277
IDENTIFICATION OF LOW-MOLECULAR-WEIGHT GP IIB IIIA ANTAGONISTS THAT BIND PREFERENTIALLY TO ACTIVATED PLATELETS/
Authors: BEDNAR RA GAUL SL HAMILL TG EGBERTSON MS SHAFER JA HARTMAN GD GOULD RJ BEDNAR B
Citation: Ra. Bednar et al., IDENTIFICATION OF LOW-MOLECULAR-WEIGHT GP IIB IIIA ANTAGONISTS THAT BIND PREFERENTIALLY TO ACTIVATED PLATELETS/, The Journal of pharmacology and experimental therapeutics, 285(3), 1998, pp. 1317-1326
FARNESYLTRANSFERASE INHIBITORS VERSUS RAS INHIBITORS
Authors: GIBBS JB GRAHAM SL HARTMAN GD KOBLAN KS KOHL NE OMER CA OLIFF A
Citation: Jb. Gibbs et al., FARNESYLTRANSFERASE INHIBITORS VERSUS RAS INHIBITORS, CURRENT OPINION IN CHEMICAL BIOLOGY, 1(2), 1997, pp. 197-203
NONPEPTIDE GPIIB IIIA INHIBITORS .16. THIENO[2,3-B]THIOPHENE ALPHA-SULFONAMIDES ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/
Authors: PRUGH JD GOULD RJ LYNCH RJ ZHANG GX COOK JJ HOLAHAN MA STRANIERI MT SITKO GR GAUL SL BEDNAR RA BEDNAR B HARTMAN GD
Citation: Jd. Prugh et al., NONPEPTIDE GPIIB IIIA INHIBITORS .16. THIENO[2,3-B]THIOPHENE ALPHA-SULFONAMIDES ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/, Bioorganic & medicinal chemistry letters, 7(7), 1997, pp. 865-870
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .18. INDOLE ALPHA-SULFONAMIDE ACIDS ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/
Authors: BRASHEAR KM COOK JJ BEDNAR B BEDNAR RA GOULD RJ HALCZENKO W HOLAHAN MA LYNCH RJ HARTMAN GD HUTCHINSON JH
Citation: Km. Brashear et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .18. INDOLE ALPHA-SULFONAMIDE ACIDS ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/, Bioorganic & medicinal chemistry letters, 7(21), 1997, pp. 2793-2798
DIARYLETHER INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
Authors: DINSMORE CJ WILLIAMS TM HAMILTON K ONEILL TJ RANDS E KOBLAN KS KOHL NE GIBBS JB GRAHAM SL HARTMAN GD OLIFF AI
Citation: Cj. Dinsmore et al., DIARYLETHER INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE, Bioorganic & medicinal chemistry letters, 7(10), 1997, pp. 1345-1348
ANTITUMOR ACTIVITIES OF FARNESYLTRANSFERASE INHIBITORS
Authors: KOHL NE ANTHONY NJ CONNER MW DESOLMS SJ GIBBS JB GRAHAM L HARTMAN GD KOBLAN KS OMER CA PELLICER A WILLIAMS TM WINDLE JJ OLIFF A
Citation: Ne. Kohl et al., ANTITUMOR ACTIVITIES OF FARNESYLTRANSFERASE INHIBITORS, The FASEB journal, 11(9), 1997, pp. 797-797
THE EFFECT OF VARIABILITY IN THE CONCENTRATION OF RECEPTORS AND THE BINDING-AFFINITY OF FIBRINOGEN RECEPTOR ANTAGONISTS ON EFFICACY
Authors: BEDNAR B BEDNAR RA MCQUENEY PA CUNNIGHAM ME LYNCH RJ GAUL SL EGBERTSON MS HARTMAN GD GOULD RJ
Citation: B. Bednar et al., THE EFFECT OF VARIABILITY IN THE CONCENTRATION OF RECEPTORS AND THE BINDING-AFFINITY OF FIBRINOGEN RECEPTOR ANTAGONISTS ON EFFICACY, Thrombosis and haemostasis, 1997, pp. 2698-2698
EQUILIBRIUM AND DYNAMICS OF FIBRINOGEN RECEPTORS ON RESTING AND ACTIVATED PLATELETS AND IMPLICATIONS FOR THE SEPARATION OF EFFICACY AND BLEEDING-TIME
Authors: BEDNAR B BEDNAR RA MCQUENEY PA CUNNIGHAM ME EGBERTSON MS ASKEW BC COOK JJ HARTMAN GD GOULD RJ
Citation: B. Bednar et al., EQUILIBRIUM AND DYNAMICS OF FIBRINOGEN RECEPTORS ON RESTING AND ACTIVATED PLATELETS AND IMPLICATIONS FOR THE SEPARATION OF EFFICACY AND BLEEDING-TIME, Thrombosis and haemostasis, 1997, pp. 2757-2757
FLOW CYTOMETRIC MEASUREMENT OF KINETIC AND EQUILIBRIUM BINDING PARAMETERS OF ARGININE-GLYCINE-ASPARTIC ACID LIGANDS IN BINDING TO GLYCOPROTEIN IIB IIIA ON PLATELETS/
Authors: BEDNAR B CUNNINGHAM ME MCQUENEY PA EGBERTSON MS ASKEW BC BEDNAR RA HARTMAN GD GOULD RJ
Citation: B. Bednar et al., FLOW CYTOMETRIC MEASUREMENT OF KINETIC AND EQUILIBRIUM BINDING PARAMETERS OF ARGININE-GLYCINE-ASPARTIC ACID LIGANDS IN BINDING TO GLYCOPROTEIN IIB IIIA ON PLATELETS/, Cytometry, 28(1), 1997, pp. 58-65
IN-VITRO AND IN-VIVO EVALUATIONS OF THE METABOLISM, PHARMACOKINETICS,AND BIOAVAILABILITY OF ESTER PRODRUGS OF L-767,679, A POTENT FIBRINOGEN RECEPTOR ANTAGONIST - AN APPROACH FOR THE SELECTION OF A PRODRUG CANDIDATE
Authors: PRUEKSARITANONT T GORHAM LM BRESLIN MJ HUTCHINSON JH HARTMAN GD VYAS KP BAILLIE TA
Citation: T. Prueksaritanont et al., IN-VITRO AND IN-VIVO EVALUATIONS OF THE METABOLISM, PHARMACOKINETICS,AND BIOAVAILABILITY OF ESTER PRODRUGS OF L-767,679, A POTENT FIBRINOGEN RECEPTOR ANTAGONIST - AN APPROACH FOR THE SELECTION OF A PRODRUG CANDIDATE, Drug metabolism and disposition, 25(8), 1997, pp. 978-984
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .15. ANTITHROMBOTIC EFFICACY OF L-738,167, A LONG-ACTING GPIIB/IIIA ANTAGONIST, CORRELATES WITHINHIBITION OF ADENOSINE DIPHOSPHATE-INDUCED PLATELET-AGGREGATION BUT NOT WITH BLEEDING-TIME PROLONGATION/
Authors: COOK JJ SITKO GR HOLAHAN MA STRANIERI MT GLASS JD ASKEW BC MCINTYRE CJ CLAREMON DA BALDWIN JJ HARTMAN GD GOULD RJ LYNCH JJ
Citation: Jj. Cook et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .15. ANTITHROMBOTIC EFFICACY OF L-738,167, A LONG-ACTING GPIIB/IIIA ANTAGONIST, CORRELATES WITHINHIBITION OF ADENOSINE DIPHOSPHATE-INDUCED PLATELET-AGGREGATION BUT NOT WITH BLEEDING-TIME PROLONGATION/, The Journal of pharmacology and experimental therapeutics, 281(2), 1997, pp. 677-689
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .17. DESIGN AND SYNTHESISOF ORALLY-ACTIVE, LONG-ACTING NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS/
Authors: ASKEW BC BEDNAR RA BEDNAR B CLAREMON DA COOK JJ MCINTYRE CJ HUNT CA GOULD RJ LYNCH RJ LYNCH JJ GAUL SL STRANIERI MT SITKO GR HOLAHAN MA GLASS JD HAMILL T GORHAM LM PRUEKSARITANONT T BALDWIN JJ HARTMAN GD
Citation: Bc. Askew et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .17. DESIGN AND SYNTHESISOF ORALLY-ACTIVE, LONG-ACTING NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS/, Journal of medicinal chemistry, 40(12), 1997, pp. 1779-1788
NONPEPTIDE GLYCOPROTEIN IIB LIIA INHIBITORS .14. ORAL ANTITHROMBOTIC EFFICACY OF L-738,167 IN A CONSCIOUS CANINE MODEL OF CORONARY-ARTERY ELECTROLYTIC INJURY/
Authors: COOK JJ GLASS JD SITKO GR HOLAHAN MA STUPIENSKI RF WALLACE AA STUMP GL HAND EL ASKEW BC HARTMAN GD GOULD RJ LYNCH JJ
Citation: Jj. Cook et al., NONPEPTIDE GLYCOPROTEIN IIB LIIA INHIBITORS .14. ORAL ANTITHROMBOTIC EFFICACY OF L-738,167 IN A CONSCIOUS CANINE MODEL OF CORONARY-ARTERY ELECTROLYTIC INJURY/, Circulation, 96(3), 1997, pp. 949-958
RGD LIGANDS INDUCE A COMMON NEO-EPITOPE UPON BINDING TO ALPHA(IIB)BETA(3) ON PLATELETS
Authors: MCQUENEY PA BOLLAG DM EGBERTSON MS HARTMAN GD GOULD RJ BEDNAR B
Citation: Pa. Mcqueney et al., RGD LIGANDS INDUCE A COMMON NEO-EPITOPE UPON BINDING TO ALPHA(IIB)BETA(3) ON PLATELETS, Molecular biology of the cell, 7, 1996, pp. 1436-1436
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .12. POTENT AND ORALLY-ACTIVE CENTRALLY CONSTRAINED THIENO[2,3-C]PYRIDONES/
Authors: HALCZENKO W COOK JJ HOLAHAN MA SITKO GR STRANIERI MT ZHANG GX LYNCH RJ LYNCH JJ GOULD RJ HARTMAN GD
Citation: W. Halczenko et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .12. POTENT AND ORALLY-ACTIVE CENTRALLY CONSTRAINED THIENO[2,3-C]PYRIDONES/, Bioorganic & medicinal chemistry letters, 6(22), 1996, pp. 2771-2776
NONPEPTIDE GPIIB IIIA INHIBITORS .10. CENTRALLY CONSTRAINED ALPHA-SULFONAMIDES ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/
Authors: EGBERTSON MS HARTMAN GD GOULD RJ BEDNAR B BEDNAR RA COOK JJ GAUL SL HOLAHAN MA LIBBY LA LYNCH JJ LYNCH RJ SITKO GR STRANIERI MT VASSALLO LM
Citation: Ms. Egbertson et al., NONPEPTIDE GPIIB IIIA INHIBITORS .10. CENTRALLY CONSTRAINED ALPHA-SULFONAMIDES ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/, Bioorganic & medicinal chemistry letters, 6(21), 1996, pp. 2519-2524
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .9. CENTRALLY CONSTRAINEDALPHA-SULFONAMIDES ARE USEFUL TOOLS FOR EXPLORING PLATELET RECEPTOR FUNCTION/
Authors: EGBERTSON MS BEDNAR B BEDNAR RA HARTMAN GD GOULD RJ LYNCH RJ VASSALLO LM YOUNG SD
Citation: Ms. Egbertson et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .9. CENTRALLY CONSTRAINEDALPHA-SULFONAMIDES ARE USEFUL TOOLS FOR EXPLORING PLATELET RECEPTOR FUNCTION/, Bioorganic & medicinal chemistry letters, 6(12), 1996, pp. 1415-1420
THE SYNTHESIS OF [H-3] L-734,217, AN ORALLY-ACTIVE FIBRINOGEN RECEPTOR ANTAGONIST
Authors: HAMILL TG DUGGAN ME HARTMAN GD HOFFMAN WF PERKINS JJ BURNS HD
Citation: Tg. Hamill et al., THE SYNTHESIS OF [H-3] L-734,217, AN ORALLY-ACTIVE FIBRINOGEN RECEPTOR ANTAGONIST, Journal of labelled compounds & radiopharmaceuticals, 38(6), 1996, pp. 533-540
FARNESYLTRANSFERASE INHIBITORS - A NEW CLASS OF CANCER CHEMOTHERAPEUTICS
Authors: KOBLAN KS KOHL NE OMER CA ANTHONY NJ CONNER MW DESOLMS SJ WILLIAMS TM GRAHAM SL HARTMAN GD OLIFF A GIBBS JB
Citation: Ks. Koblan et al., FARNESYLTRANSFERASE INHIBITORS - A NEW CLASS OF CANCER CHEMOTHERAPEUTICS, Biochemical Society transactions, 24(3), 1996, pp. 688-692
FARNESYLTRANSFERASE INHIBITORS AND ANTI-RAS THERAPY
Authors: GIBBS JB KOHL NE KOBLAN KS OMER CA SEPPLORENZINO L ROSEN N ANTHONY NJ CONNER MW DESOLMS SJ WILLIAMS TM GRAHAM SL HARTMAN GD OLIFF A
Citation: Jb. Gibbs et al., FARNESYLTRANSFERASE INHIBITORS AND ANTI-RAS THERAPY, Breast cancer research and treatment, 38(1), 1996, pp. 75-83
STUDIES DIRECTED TOWARD THE REGIOSELECTIVE CARBOXYLATION OF THE 4-OXO-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE RING-SYSTEM
Authors: HALCZENKO W HARTMAN GD
Citation: W. Halczenko et Gd. Hartman, STUDIES DIRECTED TOWARD THE REGIOSELECTIVE CARBOXYLATION OF THE 4-OXO-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE RING-SYSTEM, Synthetic communications, 26(7), 1996, pp. 1363-1370
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .8. ANTIPLATELET ACTIVITYAND ORAL ANTITHROMBOTIC EFFICACY OF L-734,217/
Authors: COOK JJ HOLAHAN MA LYLE EA RAMJIT DR SITKO GR STRANIERI MT STUPIENSKI RF WALLACE AA HAND EL GEHRET JR KOTHSTEIN T DRAG MD MCCORMICK GY PERKINS JJ IHLE NC DUGGAN ME HARTMAN GD GOULD RJ LYNCH JJ
Citation: Jj. Cook et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .8. ANTIPLATELET ACTIVITYAND ORAL ANTITHROMBOTIC EFFICACY OF L-734,217/, The Journal of pharmacology and experimental therapeutics, 278(1), 1996, pp. 62-73
A-SUBSTITUTED PIPERAZINES AS CONSTRAINED AMINO-ACIDS - APPLICATION TOTHE SYNTHESIS OF POTENT, NON CARBOXYLIC-ACID INHIBITORS OF FARNESYLTRANSFERASE
Authors: WILLIAMS TM CICCARONE TM MACTOUGH SC BOCK RL CONNER MW DAVIDE JP HAMILTON K KOBLAN KS KOHL NE KRAL AM MOSSER SD OMER CA POMPLIANO DL RANDS E SCHABER MD SHAH D WILSON FR GIBBS JB GRAHAM SL HARTMAN GD OLIFF AI SMITH RL
Citation: Tm. Williams et al., A-SUBSTITUTED PIPERAZINES AS CONSTRAINED AMINO-ACIDS - APPLICATION TOTHE SYNTHESIS OF POTENT, NON CARBOXYLIC-ACID INHIBITORS OF FARNESYLTRANSFERASE, Journal of medicinal chemistry, 39(7), 1996, pp. 1345-1348
Risultati: 1-25 | 26-48