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Results: 1-25 | 26-30
Results: 1-25/30
THE SYNTHESIS OF SYMMETRICAL AND UNSYMMETRICAL P1 P1' CYCLIC UREAS ASHIV PROTEASE INHIBITORS/
Authors: PATEL M KALTENBACH RF NUGIEL DA MCHUGH RJ JADHAV PK BACHELER LT CORDOVA BC KLABE RM ERICKSONVIITANEN S GARBER S REID C SEITZ SP
Citation: M. Patel et al., THE SYNTHESIS OF SYMMETRICAL AND UNSYMMETRICAL P1 P1' CYCLIC UREAS ASHIV PROTEASE INHIBITORS/, Bioorganic & medicinal chemistry letters, 8(9), 1998, pp. 1077-1082
NONPEPTIDE CYCLIC CYANOGUANIDINES AS HIV-1 PROTEASE INHIBITORS - SYNTHESIS, STRUCTURE-ACTIVITY-RELATIONSHIPS, AND X-RAY CRYSTAL-STRUCTURE STUDIES
Authors: JADHAV PK WOERNER FJ LAM PYS HODGE CN EYERMANN CJ MAN HW DANEKER WF BACHELER LT RAYNER MM MEEK JL ERICKSONVIITANEN S JACKSON DA CALABRESE JC SCHADT M CHANG CH
Citation: Pk. Jadhav et al., NONPEPTIDE CYCLIC CYANOGUANIDINES AS HIV-1 PROTEASE INHIBITORS - SYNTHESIS, STRUCTURE-ACTIVITY-RELATIONSHIPS, AND X-RAY CRYSTAL-STRUCTURE STUDIES, Journal of medicinal chemistry, 41(9), 1998, pp. 1446-1455
CYCLIC HIV PROTEASE INHIBITORS - DESIGN AND SYNTHESIS OF ORALLY BIOAVAILABLE, PYRAZOLE P2 P2' CYCLIC UREAS WITH IMPROVED POTENCY/
Authors: HAN Q CHANG CH LI RH RU Y JADHAV PK LAM PYS
Citation: Q. Han et al., CYCLIC HIV PROTEASE INHIBITORS - DESIGN AND SYNTHESIS OF ORALLY BIOAVAILABLE, PYRAZOLE P2 P2' CYCLIC UREAS WITH IMPROVED POTENCY/, Journal of medicinal chemistry, 41(12), 1998, pp. 2019-2028
MOLECULAR RECOGNITION OF CYCLIC UREA HIV-1 PROTEASE INHIBITORS
Authors: ALA PJ DELOSKEY RJ HUSTON EE JADHAV PK LAM PYS EYERMANN CJ HODGE CN SCHADT MC LEWANDOWSKI FA WEBER PC MCCABE DD DUKE JL CHANG CH
Citation: Pj. Ala et al., MOLECULAR RECOGNITION OF CYCLIC UREA HIV-1 PROTEASE INHIBITORS, The Journal of biological chemistry, 273(20), 1998, pp. 12325-12331
COUNTERACTING HIV-1 PROTEASE DRUG-RESISTANCE - STRUCTURAL-ANALYSIS OFMUTANT PROTEASES COMPLEXED WITH XV638 AND SD146, CYCLIC UREA AMIDES WITH BROAD SPECIFICITIES
Authors: ALA PJ HUSTON EE KLABE RM JADHAV PK LAM PYS CHANG CH
Citation: Pj. Ala et al., COUNTERACTING HIV-1 PROTEASE DRUG-RESISTANCE - STRUCTURAL-ANALYSIS OFMUTANT PROTEASES COMPLEXED WITH XV638 AND SD146, CYCLIC UREA AMIDES WITH BROAD SPECIFICITIES, Biochemistry (Easton), 37(43), 1998, pp. 15042-15049
CALCULATED AND EXPERIMENTAL LOW-ENERGY CONFORMATIONS OF CYCLIC UREA HIV PROTEASE INHIBITORS
Authors: HODGE CN LAM PYS EYERMANN CJ JADHAV PK RU Y FERNANDEZ CH DELUCCA GV CHANG CH KALTENBACH RF HOLLER ER WOERNER F DANEKER WF EMMETT G CALABRESE JC ALDRICH PE
Citation: Cn. Hodge et al., CALCULATED AND EXPERIMENTAL LOW-ENERGY CONFORMATIONS OF CYCLIC UREA HIV PROTEASE INHIBITORS, Journal of the American Chemical Society, 120(19), 1998, pp. 4570-4581
SYNTHESIS OF 7-MEMBERED CYCLIC HYDROXYGUANIDINES - NOVEL HIV-1 PROTEASE INHIBITORS
Authors: JADHAV PK WOERNER FJ MAN HW
Citation: Pk. Jadhav et al., SYNTHESIS OF 7-MEMBERED CYCLIC HYDROXYGUANIDINES - NOVEL HIV-1 PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 7(17), 1997, pp. 2145-2148
MOLECULAR RECOGNITION OF CYCLIC HIV PROTEASE INHIBITORS - NONSYMMETRIC CYCLIC UREAS WITH EXCELLENT ORAL BIOAVAILABILITY AND LOW DRUG-RESISTANCE PROFILES
Authors: LAM PYS RODGERS JD LI R RU Y JADHAV PK CHANG CH CLARK CG SEITZ SP KO SS BACHELER LT KLABE RM LAM GN WRIGHT MR ERICKSONVIITANEN S TRAINOR GL ANDERSON PS
Citation: Pys. Lam et al., MOLECULAR RECOGNITION OF CYCLIC HIV PROTEASE INHIBITORS - NONSYMMETRIC CYCLIC UREAS WITH EXCELLENT ORAL BIOAVAILABILITY AND LOW DRUG-RESISTANCE PROFILES, The FASEB journal, 11(9), 1997, pp. 48-48
CYCLIC UREA AMIDES - HIV-1 PROTEASE INHIBITORS WITH LOW NANOMOLAR POTENCY AGAINST BOTH WILD-TYPE AND PROTEASE INHIBITOR RESISTANT MUTANTS OF HIV
Authors: JADHAV PK ALA P WOERNER FJ CHANG CH GARBER SS ANTON ED BACHELER LT
Citation: Pk. Jadhav et al., CYCLIC UREA AMIDES - HIV-1 PROTEASE INHIBITORS WITH LOW NANOMOLAR POTENCY AGAINST BOTH WILD-TYPE AND PROTEASE INHIBITOR RESISTANT MUTANTS OF HIV, Journal of medicinal chemistry, 40(2), 1997, pp. 181-191
IMPROVED P1 P1' SUBSTITUENTS FOR CYCLIC UREA BASED HIV-1 PROTEASE INHIBITORS - SYNTHESIS, STRUCTURE-ACTIVITY RELATIONSHIP, AND X-RAY CRYSTAL-STRUCTURE ANALYSIS/
Authors: NUGIEL DA JACOBS K CORNELIUS L CHANG CH JADHAV PK HOLLER ER KLABE RM BACHELER LT CORDOVA B GARBER S REID C LOGUE KA GOREYFERET LJ LAM GN ERICKSONVIITANEN S SEITZ SP
Citation: Da. Nugiel et al., IMPROVED P1 P1' SUBSTITUENTS FOR CYCLIC UREA BASED HIV-1 PROTEASE INHIBITORS - SYNTHESIS, STRUCTURE-ACTIVITY RELATIONSHIP, AND X-RAY CRYSTAL-STRUCTURE ANALYSIS/, Journal of medicinal chemistry, 40(10), 1997, pp. 1465-1474
ENANTIOTOPIC DIFFERENTIATION OF PRO-R OR PRO-S CHLORIDES IN (DICHLOROMETHYL)BORATES BY CHIRAL LEWIS-ACIDS - ENANTIOSELECTIVE SYNTHESIS OF (ALPHA-CHLOROALKYL)BORONATES
Authors: JADHAV PK MAN HW
Citation: Pk. Jadhav et Hw. Man, ENANTIOTOPIC DIFFERENTIATION OF PRO-R OR PRO-S CHLORIDES IN (DICHLOROMETHYL)BORATES BY CHIRAL LEWIS-ACIDS - ENANTIOSELECTIVE SYNTHESIS OF (ALPHA-CHLOROALKYL)BORONATES, Journal of the American Chemical Society, 119(4), 1997, pp. 846-847
IMPROVED CYCLIC UREA INHIBITORS OF THE HIV-I PROTEASE - SYNTHESIS, POTENCY, RESISTANCE PROFILE, HUMAN PHARMACOKINETICS AND X-RAY CRYSTAL-STRUCTURE OF DMP-450
Authors: HODGE CN ALDRICH PE BACHELER LT CHANG CH EYERMANN CJ GARBER S GRUBB M JACKSON DA JADHAV PK KORANT B LAM PYS MAURIN MB MEEK JL OTTO MJ RAYNER MM REID C SHARPE TR SHUM L WINSLOW DL ERICKSONVIITANEN S
Citation: Cn. Hodge et al., IMPROVED CYCLIC UREA INHIBITORS OF THE HIV-I PROTEASE - SYNTHESIS, POTENCY, RESISTANCE PROFILE, HUMAN PHARMACOKINETICS AND X-RAY CRYSTAL-STRUCTURE OF DMP-450, Chemistry & biology, 3(4), 1996, pp. 301-314
SYNTHESIS OF WATER-SOLUBLE PRODRUG OF DMP323
Authors: JADHAV PK WOERNER FJ AUNGST BJ
Citation: Pk. Jadhav et al., SYNTHESIS OF WATER-SOLUBLE PRODRUG OF DMP323, Bioorganic & medicinal chemistry letters, 6(19), 1996, pp. 2259-2262
SYNTHESIS OF 7-MEMBERED CYCLIC OXAMIDES - NOVEL HIV-1 PROTEASE INHIBITORS
Authors: JADHAV PK MAN HW
Citation: Pk. Jadhav et Hw. Man, SYNTHESIS OF 7-MEMBERED CYCLIC OXAMIDES - NOVEL HIV-1 PROTEASE INHIBITORS, Tetrahedron letters, 37(8), 1996, pp. 1153-1156
DIRECT SYNTHESIS OF [ALPHA-[(TERT-BUTOXYCARBONYL)AMINO]ALKYL]BORONATES FROM (ALPHA-HALOALKYL)BORONATES
Authors: JADHAV PK MAN HW
Citation: Pk. Jadhav et Hw. Man, DIRECT SYNTHESIS OF [ALPHA-[(TERT-BUTOXYCARBONYL)AMINO]ALKYL]BORONATES FROM (ALPHA-HALOALKYL)BORONATES, Journal of organic chemistry, 61(22), 1996, pp. 7951-7954
STEREOSELECTIVE SYNTHESIS OF HIV-1 PROTEASE INHIBITOR, DMP-323
Authors: PIERCE ME HARRIS GD ISLAM Q RADESCA LA STORACE L WALTERMIRE RE WAT E JADHAV PK EMMETT GC
Citation: Me. Pierce et al., STEREOSELECTIVE SYNTHESIS OF HIV-1 PROTEASE INHIBITOR, DMP-323, Journal of organic chemistry, 61(2), 1996, pp. 444-450
CYCLIC HIV PROTEASE INHIBITORS - SYNTHESIS, CONFORMATIONAL-ANALYSIS, P2 P2' STRUCTURE-ACTIVITY RELATIONSHIP, AND MOLECULAR RECOGNITION OF CYCLIC UREAS/
Authors: LAM PYS RU Y JADHAV PK ALDRICH PE DELUCCA GV EYERMANN CJ CHANG CH EMMETT G HOLLER ER DANEKER WF LI LZ CONFALONE PN MCHUGH RJ HAN Q LI RH MARKWALDER JA SEITZ SP SHARPE TR BACHELER LT RAYNER MM KLABE RM SHUM LY WINSLOW DL KORNHAUSER DM JACKSON DA ERICKSONVIITANEN S HODGE CN
Citation: Pys. Lam et al., CYCLIC HIV PROTEASE INHIBITORS - SYNTHESIS, CONFORMATIONAL-ANALYSIS, P2 P2' STRUCTURE-ACTIVITY RELATIONSHIP, AND MOLECULAR RECOGNITION OF CYCLIC UREAS/, Journal of medicinal chemistry, 39(18), 1996, pp. 3514-3525
PREPARATION AND STRUCTURE-ACTIVITY RELATIONSHIP OF NOVEL P1 P1'-SUBSTITUTED CYCLIC UREA-BASED HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INHIBITORS/
Authors: NUGIEL DA JACOBS K WORLEY T PATEL M KALTENBACH RF MEYER DT JADHAV PK DELUCCA GV SMYSER TE KLABE RM BACHELER LT RAYNER MM SEITZ SP
Citation: Da. Nugiel et al., PREPARATION AND STRUCTURE-ACTIVITY RELATIONSHIP OF NOVEL P1 P1'-SUBSTITUTED CYCLIC UREA-BASED HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INHIBITORS/, Journal of medicinal chemistry, 39(11), 1996, pp. 2156-2169
POLAROGRAPHIC ANALYSIS OF THE HYDROLYSIS OF 2-CARBOXY-4-AMINODIPHENYLSULFIDE AND 2-CARBOXY-4-AMINODIPHENYL SULFONE IN AQUEOUS-SOLUTION
Authors: JADHAV PK BALGI VD ASHTAMKAR SM SHAIKH MM
Citation: Pk. Jadhav et al., POLAROGRAPHIC ANALYSIS OF THE HYDROLYSIS OF 2-CARBOXY-4-AMINODIPHENYLSULFIDE AND 2-CARBOXY-4-AMINODIPHENYL SULFONE IN AQUEOUS-SOLUTION, Journal of the Indian Chemical Society, 73(12), 1996, pp. 682-683
FLEXIBILITY AND FUNCTION IN HIV-1 PROTEASE
Authors: NICHOLSON LK YAMAZAKI T TORCHIA DA GRZESIEK S BAX A STAHL SJ KAUFMAN JD WINGFIELD PT LAM PYS JADHAV PK HODGE CN DOMAILLE PJ CHANG CH
Citation: Lk. Nicholson et al., FLEXIBILITY AND FUNCTION IN HIV-1 PROTEASE, Nature structural biology, 2(4), 1995, pp. 274-280
SYNTHESIS OF 8-MEMBERED CYCLIC SULFAMIDES - NOVEL HIV-1 PROTEASE INHIBITORS
Authors: JADHAV PK WOERNER FJ
Citation: Pk. Jadhav et Fj. Woerner, SYNTHESIS OF 8-MEMBERED CYCLIC SULFAMIDES - NOVEL HIV-1 PROTEASE INHIBITORS, Tetrahedron letters, 36(36), 1995, pp. 6383-6386
AN ASSAY FOR HIV RNA IN INFECTED CELL LYSATES, AND ITS USE FOR THE RAPID EVALUATION OF ANTIVIRAL EFFICACY
Authors: BACHELER LT PAUL M OTTO MJ JADHAV PK STONE BA MILLER JA
Citation: Lt. Bacheler et al., AN ASSAY FOR HIV RNA IN INFECTED CELL LYSATES, AND ITS USE FOR THE RAPID EVALUATION OF ANTIVIRAL EFFICACY, Antiviral chemistry & chemotherapy, 5(2), 1994, pp. 111-121
RATIONAL DESIGN OF POTENT, BIOAVAILABLE NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS
Authors: ERICKSONVIITANEN S LAM PYS JADHAV PK EYERMANN CJ HODGE CN RU Y BACHELER LT MEEK JL OTTO MJ RAYNER MM WONG YN CHANG CH WEBER PC JACKSON DA SHARPE TR
Citation: S. Ericksonviitanen et al., RATIONAL DESIGN OF POTENT, BIOAVAILABLE NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS, Journal of cellular biochemistry, 1994, pp. 167-167
DMP-323, A NONPEPTIDE CYCLIC UREA INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) PROTEASE, SPECIFICALLY AND PERSISTENTLY BLOCKS INTRACELLULAR PROCESSING OF HIV GAG POLYPROTEIN
Authors: RAYNER MM CORDOVA BC MEADE RP ALDRICH PE JADHAV PK RU Y LAM PYS
Citation: Mm. Rayner et al., DMP-323, A NONPEPTIDE CYCLIC UREA INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) PROTEASE, SPECIFICALLY AND PERSISTENTLY BLOCKS INTRACELLULAR PROCESSING OF HIV GAG POLYPROTEIN, Antimicrobial agents and chemotherapy, 38(7), 1994, pp. 1635-1640
POTENTIALLY GENERAL-SYNTHESIS OF POLYHYDROXYINDOLIZIDINES
Authors: JADHAV PK WOERNER FJ
Citation: Pk. Jadhav et Fj. Woerner, POTENTIALLY GENERAL-SYNTHESIS OF POLYHYDROXYINDOLIZIDINES, Tetrahedron letters, 35(48), 1994, pp. 8973-8976
Risultati: 1-25 | 26-30