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Results: 1-25 | 26-26
Results: 1-25/26
PHARMACOLOGICAL CHARACTERIZATION OF A-131701, A NOVEL ALPHA(1)-ADRENOCEPTOR ANTAGONIST SELECTIVE FOR ALPHA(1A)-COMPARED AND ALPHA(1D)-COMPARED TO ALPHA(1B)-ADRENOCEPTORS
Authors: HANCOCK AA BUCKNER SA BRUNE ME KATWALA S MILICIC I IRELAND LM MORSE PA KNEPPER SM MEYER MD CHAPPLE CR CHESSWILLIAMS R NOBLE AJ WILLIAMS M KERWIN JF
Citation: Aa. Hancock et al., PHARMACOLOGICAL CHARACTERIZATION OF A-131701, A NOVEL ALPHA(1)-ADRENOCEPTOR ANTAGONIST SELECTIVE FOR ALPHA(1A)-COMPARED AND ALPHA(1D)-COMPARED TO ALPHA(1B)-ADRENOCEPTORS, Drug development research, 44(4), 1998, pp. 140-162
ACTIONS OF A-131701, A NOVEL, SELECTIVE ANTAGONIST FOR ALPHA-1A COMPARED WITH ALPHA-1B ADRENOCEPTORS ON INTRAURETHRAL AND BLOOD-PRESSURE RESPONSES IN CONSCIOUS DOGS AND A PHARMACODYNAMIC ASSESSMENT OF IN-VIVO PROSTATIC SELECTIVITY
Authors: HANCOCK AA BRUNE ME WITTE DG MARSH KC KATWALA S MILICIC I IRELAND LM CROWELL D MEYER MD KERWIN JF
Citation: Aa. Hancock et al., ACTIONS OF A-131701, A NOVEL, SELECTIVE ANTAGONIST FOR ALPHA-1A COMPARED WITH ALPHA-1B ADRENOCEPTORS ON INTRAURETHRAL AND BLOOD-PRESSURE RESPONSES IN CONSCIOUS DOGS AND A PHARMACODYNAMIC ASSESSMENT OF IN-VIVO PROSTATIC SELECTIVITY, The Journal of pharmacology and experimental therapeutics, 285(2), 1998, pp. 628-642
NITROAROMATIC AMINO-ACIDS AS INHIBITORS OF NEURONAL NITRIC-OXIDE SYNTHASE
Authors: COWART M KOWALUK EA DAANEN JF KOHLHAAS KL ALEXANDER KM WAGENAAR FL KERWIN JF
Citation: M. Cowart et al., NITROAROMATIC AMINO-ACIDS AS INHIBITORS OF NEURONAL NITRIC-OXIDE SYNTHASE, Journal of medicinal chemistry, 41(14), 1998, pp. 2636-2642
RELATIONSHIPS BETWEEN PHARMACOKINETICS AND BLOCKADE OF AGONIST-INDUCED PROSTATIC INTRAURETHRAL PRESSURE AND MEAN ARTERIAL-PRESSURE IN THE CONSCIOUS DOG AFTER SINGLE AND REPEATED DAILY ORAL-ADMINISTRATION OF TERAZOSIN
Authors: WITTE DG BRUNE ME KATWALA SP MILICIC I KERWIN JF HANCOCK AA
Citation: Dg. Witte et al., RELATIONSHIPS BETWEEN PHARMACOKINETICS AND BLOCKADE OF AGONIST-INDUCED PROSTATIC INTRAURETHRAL PRESSURE AND MEAN ARTERIAL-PRESSURE IN THE CONSCIOUS DOG AFTER SINGLE AND REPEATED DAILY ORAL-ADMINISTRATION OF TERAZOSIN, The Journal of pharmacology and experimental therapeutics, 282(2), 1997, pp. 891-898
SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION OF AHYDRO-1H-BENZ[E]ISOINDOL-2-YL)ETHYL]PYRIDO-[3',4' 4,5]THIENO[3,2-D]PYRIMIDINE-2,4(1H,3H)-DIONE (A-131701) - A UROSELECTIVE ALPHA(1A) ADRENOCEPTOR ANTAGONIST FOR THE SYMPTOMATIC TREATMENT OF BENIGN PROSTATIC HYPERPLASIA/
Authors: MEYER MD ALTENBACH RJ BASHA FZ CARROLL WA DRIZIN I ELMORE SW EHRLICH PP LEBOLD SA TIETJE K SIPPY KB WENDT MD PLATA DJ PLAGGE F BUCKNER SA BRUNE ME HANCOCK AA KERWIN JF
Citation: Md. Meyer et al., SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION OF AHYDRO-1H-BENZ[E]ISOINDOL-2-YL)ETHYL]PYRIDO-[3',4' 4,5]THIENO[3,2-D]PYRIMIDINE-2,4(1H,3H)-DIONE (A-131701) - A UROSELECTIVE ALPHA(1A) ADRENOCEPTOR ANTAGONIST FOR THE SYMPTOMATIC TREATMENT OF BENIGN PROSTATIC HYPERPLASIA/, Journal of medicinal chemistry, 40(20), 1997, pp. 3141-3143
[H-3] R-TERAZOSIN BINDS SELECTIVELY TO ALPHA(1)-ADRENOCEPTORS OVER ALPHA(1)-ADRENOCEPTORS - COMPARISON WITH RACEMIC [H-3] TERAZOSIN AND [H-3] PRAZOSIN
Authors: IRELAND LM CAIN JC ROTERT G THOMAS S SHOGHI S HANCOCK AA KERWIN JF
Citation: Lm. Ireland et al., [H-3] R-TERAZOSIN BINDS SELECTIVELY TO ALPHA(1)-ADRENOCEPTORS OVER ALPHA(1)-ADRENOCEPTORS - COMPARISON WITH RACEMIC [H-3] TERAZOSIN AND [H-3] PRAZOSIN, European journal of pharmacology, 327(1), 1997, pp. 79-86
SYNTHESIS OF PHOSPHORUS-CONTAINING AMINO-ACID-ANALOGS AS INHIBITORS OF NITRIC-OXIDE SYNTHASE
Authors: COWART M KOWALUK EA KOHLHAAS KL ALEXANDER KM KERWIN JF
Citation: M. Cowart et al., SYNTHESIS OF PHOSPHORUS-CONTAINING AMINO-ACID-ANALOGS AS INHIBITORS OF NITRIC-OXIDE SYNTHASE, Bioorganic & medicinal chemistry letters, 6(9), 1996, pp. 999-1002
RELATIONSHIP BETWEEN PLASMA-LEVELS AND BLOCKADE OF PHENYLEPHRINE-INDUCED INCREASES IN PROSTATIC INTRAURETHRAL PRESSURE AND MEAN ARTERIAL-PRESSURE FOLLOWING ACUTE AND SUBCHRONIC TERAZOSIN DOSING IN CONSCIOUS DOGS
Authors: MILICIC IP WITTE DG KATWALA SP HANCOCK AA KERWIN JF BRUNE ME
Citation: Ip. Milicic et al., RELATIONSHIP BETWEEN PLASMA-LEVELS AND BLOCKADE OF PHENYLEPHRINE-INDUCED INCREASES IN PROSTATIC INTRAURETHRAL PRESSURE AND MEAN ARTERIAL-PRESSURE FOLLOWING ACUTE AND SUBCHRONIC TERAZOSIN DOSING IN CONSCIOUS DOGS, The FASEB journal, 10(3), 1996, pp. 1002-1002
BINDING OF [H-3] TERAZOSIN AND ITS ENANTIOMERS AT ALPHA(1)-ADRENOCEPTOR SUBTYPES
Authors: IRELAND LM ROTERT G SHOGHI S THOMAS S CAIN JC HANCOCK AA KERWIN JF
Citation: Lm. Ireland et al., BINDING OF [H-3] TERAZOSIN AND ITS ENANTIOMERS AT ALPHA(1)-ADRENOCEPTOR SUBTYPES, The FASEB journal, 10(3), 1996, pp. 2415-2415
DIFFERENTIAL-EFFECTS OF VARIOUS ALPHA-1-ADRENOCEPTOR ANTAGONISTS ON UROGENITAL AND VASCULAR SMOOTH-MUSCLE IN-VIVO
Authors: KATWALA SP MILICIC IP HANCOCK AA KERWIN JF BRUNE ME
Citation: Sp. Katwala et al., DIFFERENTIAL-EFFECTS OF VARIOUS ALPHA-1-ADRENOCEPTOR ANTAGONISTS ON UROGENITAL AND VASCULAR SMOOTH-MUSCLE IN-VIVO, The FASEB journal, 10(3), 1996, pp. 2455-2455
EFFECTS OF SELECTIVE AND NONSELECTIVE ALPHA-1-ADRENOCEPTOR ANTAGONISTS ON INTRAURETHRAL AND ARTERIAL PRESSURES IN INTACT CONSCIOUS DOGS
Authors: BRUNE ME KATWALA SP MILICIC I BUCKNER SA IRELAND LM KERWIN JF HANCOCK AA
Citation: Me. Brune et al., EFFECTS OF SELECTIVE AND NONSELECTIVE ALPHA-1-ADRENOCEPTOR ANTAGONISTS ON INTRAURETHRAL AND ARTERIAL PRESSURES IN INTACT CONSCIOUS DOGS, Pharmacology, 53(6), 1996, pp. 356-368
PHARMACOLOGICAL CHARACTERIZATION OF CHIR-2279, AN N-SUBSTITUTED GLYCINE PEPTOID WITH HIGH-AFFINITY BINDING FOR ALPHA(1)-ADRENOCEPTORS
Authors: GIBBONS JA HANCOCK AA VITT CR KNEPPER S BUCKNER SA BRUNE ME MILICIC I KERWIN JF RICHTER LS TAYLOR EW SPEAR KL ZUCKERMANN RN SPELLMEYER DC BRAECKMAN RA MOOS WH
Citation: Ja. Gibbons et al., PHARMACOLOGICAL CHARACTERIZATION OF CHIR-2279, AN N-SUBSTITUTED GLYCINE PEPTOID WITH HIGH-AFFINITY BINDING FOR ALPHA(1)-ADRENOCEPTORS, The Journal of pharmacology and experimental therapeutics, 277(2), 1996, pp. 885-899
SYNTHESIS AND IN-VITRO CHARACTERIZATION OF 6,7,8-TETRAHYDRONAPHTHALEN-1-YL]METHANESULFONAMIDE AND ITS ENANTIOMERS - A NOVEL SELECTIVE ALPHA(1A) RECEPTOR AGONIST
Authors: MEYER MD ALTENBACH RJ HANCOCK AA BUCKNER SA KNEPPER SM KERWIN JF
Citation: Md. Meyer et al., SYNTHESIS AND IN-VITRO CHARACTERIZATION OF 6,7,8-TETRAHYDRONAPHTHALEN-1-YL]METHANESULFONAMIDE AND ITS ENANTIOMERS - A NOVEL SELECTIVE ALPHA(1A) RECEPTOR AGONIST, Journal of medicinal chemistry, 39(20), 1996, pp. 4116-4119
ACTIONS OF TERAZOSIN AND ITS ENANTIOMERS AT SUBTYPES OF ALPHA(1)-ADRENOCEPTOR AND ALPHA(2)-ADRENOCEPTOR IN-VITRO
Authors: HANCOCK AA BUCKNER SA IRELAND LM KNEPPER SM KERWIN JF
Citation: Aa. Hancock et al., ACTIONS OF TERAZOSIN AND ITS ENANTIOMERS AT SUBTYPES OF ALPHA(1)-ADRENOCEPTOR AND ALPHA(2)-ADRENOCEPTOR IN-VITRO, Journal of receptor and signal transduction research, 15(7-8), 1995, pp. 863-885
AMINO ACID-DERIVED PIPREIDIDES AS NOVEL CCKB LIGANDS WITH ANXIOLYTIC-LIKE PROPERTIES
Authors: HOLLADAY MW BENNETT MJ BAI H RALSTON JW KERWIN JF STASHKO M MILLER TR ONEILL AB NADZAN AM BRIONI J LIN CW
Citation: Mw. Holladay et al., AMINO ACID-DERIVED PIPREIDIDES AS NOVEL CCKB LIGANDS WITH ANXIOLYTIC-LIKE PROPERTIES, Bioorganic & medicinal chemistry letters, 5(24), 1995, pp. 3057-3062
SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION OF A-80426 - A PUTATIVE NOVEL ANTIDEPRESSANT COMBINING ALPHA-2 ANTAGONISM WITH 5-HT UPTAKE INHIBITION
Authors: MEYER MD HANCOCK AA TIETJE K SIPPY KB GIARDINA WJ KERWIN JF
Citation: Md. Meyer et al., SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION OF A-80426 - A PUTATIVE NOVEL ANTIDEPRESSANT COMBINING ALPHA-2 ANTAGONISM WITH 5-HT UPTAKE INHIBITION, Bioorganic & medicinal chemistry letters, 5(19), 1995, pp. 2287-2292
A-84643 SELECTIVELY INHIBITS BRAIN NITRIC-OXIDE SYNTHASE
Authors: KOWALUK EA KOHLHAAS KL GUNTHER KL ALEXANDER KM DAANEN J COWART M WAGENAAR F KERWIN JF
Citation: Ea. Kowaluk et al., A-84643 SELECTIVELY INHIBITS BRAIN NITRIC-OXIDE SYNTHASE, The FASEB journal, 9(4), 1995, pp. 680-680
COMPARISON OF ALPHA(1) ADRENERGIC-RECEPTOR SUBTYPES IN RECEPTOR-BINDING AND FUNCTIONAL MODELS
Authors: IRELAND LM KNEPPER S BUCKNER SA BRUNE M HANCOCK AA KERWIN JF
Citation: Lm. Ireland et al., COMPARISON OF ALPHA(1) ADRENERGIC-RECEPTOR SUBTYPES IN RECEPTOR-BINDING AND FUNCTIONAL MODELS, The FASEB journal, 9(3), 1995, pp. 105-105
FUNCTIONAL AND RADIOLIGAND BINDING EVIDENCE FOR AN ALPHA(1D)-ADRENOCEPTOR SUBTYPE MEDIATING CONTRACTION IN THE RAT AORTA
Authors: BUCKNER SA OHEIM K MORSE P KNEPPER S HANCOCK AA KERWIN JF
Citation: Sa. Buckner et al., FUNCTIONAL AND RADIOLIGAND BINDING EVIDENCE FOR AN ALPHA(1D)-ADRENOCEPTOR SUBTYPE MEDIATING CONTRACTION IN THE RAT AORTA, The FASEB journal, 9(3), 1995, pp. 105-105
PHARMACOLOGICAL ACTIONS OF A-80426, A POTENTIAL ANTIDEPRESSANT COMPOUND THAT INHIBITS NEURONAL SEROTONIN UPTAKE AND BLOCKS ALPHA(2)-ADRENERGIC RECEPTORS
Authors: HANCOCK AA BUCKNER SA OHEIM K MORSE PA MILICIC I BRUNE MA MEYER MD KERWIN JF
Citation: Aa. Hancock et al., PHARMACOLOGICAL ACTIONS OF A-80426, A POTENTIAL ANTIDEPRESSANT COMPOUND THAT INHIBITS NEURONAL SEROTONIN UPTAKE AND BLOCKS ALPHA(2)-ADRENERGIC RECEPTORS, The FASEB journal, 9(3), 1995, pp. 408-408
A-80426, A POTENT ALPHA(2)-ADRENOCEPTOR ANTAGONIST WITH SEROTONIN UPTAKE BLOCKING ACTIVITY AND PUTATIVE ANTIDEPRESSANT-LIKE EFFECTS .1. BIOCHEMICAL PROFILE
Authors: HANCOCK AA BUCKNER SA OHEIM KW MORSE PA BRUNE ME MEYER MD WILLIAMS M KERWIN JF
Citation: Aa. Hancock et al., A-80426, A POTENT ALPHA(2)-ADRENOCEPTOR ANTAGONIST WITH SEROTONIN UPTAKE BLOCKING ACTIVITY AND PUTATIVE ANTIDEPRESSANT-LIKE EFFECTS .1. BIOCHEMICAL PROFILE, Drug development research, 35(4), 1995, pp. 237-245
A-80426, A POTENT AND SELECTIVE ALPHA(2)-ADRENOCEPTOR ANTAGONIST WITHSEROTONIN UPTAKE-BLOCKING ACTIVITY AND PUTATIVE ANTIDEPRESSANT-LIKE EFFECTS .2. PHARMACOLOGY PROFILE
Authors: GIARDINA WJ BUCKNER SA BRUNE ME HANCOCK AA WISMER CT MILICIC I RATTIN AJ ROUX S WETTSTEIN JG MEYER MD PORSOLT RD KERWIN JF WILLIAMS M
Citation: Wj. Giardina et al., A-80426, A POTENT AND SELECTIVE ALPHA(2)-ADRENOCEPTOR ANTAGONIST WITHSEROTONIN UPTAKE-BLOCKING ACTIVITY AND PUTATIVE ANTIDEPRESSANT-LIKE EFFECTS .2. PHARMACOLOGY PROFILE, Drug development research, 35(4), 1995, pp. 246-260
PHARMACOLOGICAL ANTAGONISM OF ALPHA-ADRENERGIC AGONIST-INDUCED INCREASES IN CANINE INTRAURETHRAL PRESSURE IN-VIVO
Authors: BRUNE ME BUCKNER SA POLAKOWSKI J KERWIN JF HANCOCK AA
Citation: Me. Brune et al., PHARMACOLOGICAL ANTAGONISM OF ALPHA-ADRENERGIC AGONIST-INDUCED INCREASES IN CANINE INTRAURETHRAL PRESSURE IN-VIVO, Drug development research, 34(3), 1995, pp. 267-275
NITRIC-OXIDE - A NEW PARADIGM FOR 2ND-MESSENGERS
Authors: KERWIN JF LANCASTER JR FELDMAN PL
Citation: Jf. Kerwin et al., NITRIC-OXIDE - A NEW PARADIGM FOR 2ND-MESSENGERS, Journal of medicinal chemistry, 38(22), 1995, pp. 4343-4362
THE ARGININE-NITRIC OXIDE PATHWAY - A TARGET FOR NEW DRUGS
Authors: KERWIN JF HELLER M
Citation: Jf. Kerwin et M. Heller, THE ARGININE-NITRIC OXIDE PATHWAY - A TARGET FOR NEW DRUGS, Medicinal research reviews, 14(1), 1994, pp. 23-74
Risultati: 1-25 | 26-26