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Results: 1-14 |
Results: 14
Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core
Authors: Fevig, JM Pinto, DJ Han, Q Quan, ML Pruitt, JR Jacobson, IC Galemmo, RA Wang, SA Orwat, MJ Bostrom, LL Knabb, RM Wong, PC Lam, PYS Wexler, RR
Citation: Jm. Fevig et al., Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core, BIOORG MED, 11(5), 2001, pp. 641-645
Discovery of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2 '- (methylsulfonyl)-[1,1 '-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa
Authors: Pinto, DJP Orwat, MJ Wang, SG Fevig, JM Quan, ML Amparo, E Cacciola, J Rossi, KA Alexander, RS Smallwood, AM Luettgen, JM Liang, L Aungst, BJ Wright, MR Knabb, RM Wong, PC Wexler, RR Lam, PYS
Citation: Djp. Pinto et al., Discovery of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2 '- (methylsulfonyl)-[1,1 '-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa, J MED CHEM, 44(4), 2001, pp. 566-578
Isoxazolines and isoxazoles as Factor Xa inhibitors
Authors: Pruitt, JR Pinto, DJ Estrella, MJ Bostrom, LL Knabb, RM Wong, PC Wright, MR Wexler, RR
Citation: Jr. Pruitt et al., Isoxazolines and isoxazoles as Factor Xa inhibitors, BIOORG MED, 10(8), 2000, pp. 685-689
The de novo design and synthesis of cyclic urea inhibitors of factor Xa: Optimization of the S4 ligand
Authors: Galemmo, RA Wells, BL Rossi, KA Alexander, RS Dominguez, C Maduskuie, TP Stouten, PFW Wright, MR Aungst, BJ Wong, PC Knabb, RM Wexler, RR
Citation: Ra. Galemmo et al., The de novo design and synthesis of cyclic urea inhibitors of factor Xa: Optimization of the S4 ligand, BIOORG MED, 10(3), 2000, pp. 301-304
Synthesis and activity studies of conformationally restricted alpha-ketoamide factor Xa inhibitors
Authors: Cacciola, J Fevig, JM Stouten, PFW Alexander, RS Knabb, RM Wexler, RR
Citation: J. Cacciola et al., Synthesis and activity studies of conformationally restricted alpha-ketoamide factor Xa inhibitors, BIOORG MED, 10(11), 2000, pp. 1253-1256
Nonpeptide factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis
Authors: Wong, PC Crain, EJ Knabb, RM Meade, RP Quan, ML Watson, CA Wexler, RR Wright, MR Slee, AM
Citation: Pc. Wong et al., Nonpeptide factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis, J PHARM EXP, 295(1), 2000, pp. 212-218
Nonpeptide factor Xa inhibitors: I. Studies with SF303 and SK549, a new class of potent antithrombotics
Authors: Wong, PC Quan, ML Crain, EJ Watson, CA Wexler, RR Knabb, RM
Citation: Pc. Wong et al., Nonpeptide factor Xa inhibitors: I. Studies with SF303 and SK549, a new class of potent antithrombotics, J PHARM EXP, 292(1), 2000, pp. 351-357
Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors
Authors: Han, Q Dominguez, C Stouten, PFW Park, JM Duffy, DE Galemmo, RA Rossi, KA Alexander, RS Smallwood, AM Wong, PC Wright, MM Luettgen, JM Knabb, RM Wexler, RR
Citation: Q. Han et al., Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors, J MED CHEM, 43(23), 2000, pp. 4398-4415
Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa
Authors: Fevig, JM Buriak, J Stouten, PFW Knabb, RM Lam, GN Wong, PC Wexler, RR
Citation: Jm. Fevig et al., Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa, BIOORG MED, 9(8), 1999, pp. 1195-1200
Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors
Authors: Dominguez, C Duffy, DE Han, Q Alexander, RS Galemmo, RA Park, JM Wong, PC Amparo, EC Knabb, RM Luettgen, J Wexler, RR
Citation: C. Dominguez et al., Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors, BIOORG MED, 9(7), 1999, pp. 925-930
Prothrombin activation in rabbits
Authors: Seiffert, D Mitchell, TJ Wang, ZY Knabb, RM Barbera, F Reilly, TM Thoolen, M
Citation: D. Seiffert et al., Prothrombin activation in rabbits, THROMB RES, 93(3), 1999, pp. 101-112
Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1
Authors: Quan, ML Liauw, AY Ellis, CD Pruitt, JR Carini, DJ Bostrom, LL Huang, PP Harrison, K Knabb, RM Thoolen, MJ Wong, PC Wexler, RR
Citation: Ml. Quan et al., Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1, J MED CHEM, 42(15), 1999, pp. 2752-2759
Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2
Authors: Quan, ML Ellis, CD Liauw, AY Alexander, RS Knabb, RM Lam, G Wright, MR Wong, PC Wexler, RR
Citation: Ml. Quan et al., Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2, J MED CHEM, 42(15), 1999, pp. 2760-2773
Preparation of meta-amidino-N,N-disubstituted anilines as potent inhibitors of coagulation factor Xa
Authors: Fevig, JM Cacciola, J Alexander, RS Knabb, RM Lam, GN Wong, PC Wexler, RR
Citation: Jm. Fevig et al., Preparation of meta-amidino-N,N-disubstituted anilines as potent inhibitors of coagulation factor Xa, BIOORG MED, 8(22), 1998, pp. 3143-3148
Risultati: 1-14 |