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Results: 1-23 |
Results: 23
STRUCTURE-BASED DESIGN OF NOVEL, DIPEPTIDE LIGANDS TARGETING THE PP60(SRC) SH2 DOMAIN
Authors: SHAHRIPOUR A PARA KS PLUMMER MS LUNNEY EA HOLLAND DR RUBIN JR HUMBLET C FERGUS JH MARKS JS SALTIEL AR SAWYER TK
Citation: A. Shahripour et al., STRUCTURE-BASED DESIGN OF NOVEL, DIPEPTIDE LIGANDS TARGETING THE PP60(SRC) SH2 DOMAIN, Bioorganic & medicinal chemistry letters, 7(9), 1997, pp. 1107-1112
THE ROLE OF 4-PHOSPHONODIFLUOROMETHYL-PHENYLALANINE AND 4-PHOSPHONO-PHENYLALANINE IN THE SELECTIVITY AND CELLULAR UPTAKE OF SH2 DOMAIN LIGANDS
Authors: STANKOVIC CJ SURENDRAN N LUNNEY EA PLUMMER MS PARA KS SHAHRIPOUR A FERGUS JH MARKS JS HERRERA R HUBBELL SE HUMBLET C SALTIEL AR STEWART BH SAWYER TK
Citation: Cj. Stankovic et al., THE ROLE OF 4-PHOSPHONODIFLUOROMETHYL-PHENYLALANINE AND 4-PHOSPHONO-PHENYLALANINE IN THE SELECTIVITY AND CELLULAR UPTAKE OF SH2 DOMAIN LIGANDS, Bioorganic & medicinal chemistry letters, 7(14), 1997, pp. 1909-1914
SYNTHESIS OF 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS HIV-1 PROTEASE INHIBITORS - THE PROFOUND EFFECT OF POLARITY ON ANTIVIRAL ACTIVITY
Authors: HAGEN SE PRASAD JVNV BOYER FE DOMAGALA JM ELLSWORTH EL GAJDA C HAMILTON HW MARKOSKI LJ STEINBAUGH BA TAIT BD LUNNEY EA TUMMINO PJ FERGUSON D HUPE D NOUHAN C GRACHECK SJ SAUNDERS JM VANDERROEST S
Citation: Se. Hagen et al., SYNTHESIS OF 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS HIV-1 PROTEASE INHIBITORS - THE PROFOUND EFFECT OF POLARITY ON ANTIVIRAL ACTIVITY, Journal of medicinal chemistry, 40(23), 1997, pp. 3707-3711
DESIGN, SYNTHESIS, AND COCRYSTAL STRUCTURE OF A NONPEPTIDE SRC SH2 DOMAIN LIGAND
Authors: PLUMMER MS HOLLAND DR SHAHRIPOUR A LUNNEY EA FERGUS JH MARKS JS MCCONNELL P MUELLER WT SAWYER TK
Citation: Ms. Plummer et al., DESIGN, SYNTHESIS, AND COCRYSTAL STRUCTURE OF A NONPEPTIDE SRC SH2 DOMAIN LIGAND, Journal of medicinal chemistry, 40(23), 1997, pp. 3719-3725
4-HYDROXY-5,6-DIHYDROPYRONES .2. POTENT NONPEPTIDE INHIBITORS OF HIV PROTEASE
Authors: TAIT BD HAGEN S DOMAGALA J ELLSWORTH EL GAJDA C HAMILTON HW PRASAD JVNV FERGUSON D GRAHAM N HUPE D NOUHAN C TUMMINO PJ HUMBLET C LUNNEY EA PAVLOVSKY A RUBIN J GRACHECK SJ BALDWIN ET BHAT TN ERICKSON JW GULNIK SV LIU BS
Citation: Bd. Tait et al., 4-HYDROXY-5,6-DIHYDROPYRONES .2. POTENT NONPEPTIDE INHIBITORS OF HIV PROTEASE, Journal of medicinal chemistry, 40(23), 1997, pp. 3781-3792
STRUCTURE-BASED DESIGN OF A NOVEL SERIES OF NONPEPTIDE LIGANDS THAT BIND TO THE PP60(SRC) SH2 DOMAIN
Authors: LUNNEY EA PARA KS RUBIN JR HUMBLET C FERGUS JH MARKS JS SAWYER TK
Citation: Ea. Lunney et al., STRUCTURE-BASED DESIGN OF A NOVEL SERIES OF NONPEPTIDE LIGANDS THAT BIND TO THE PP60(SRC) SH2 DOMAIN, Journal of the American Chemical Society, 119(51), 1997, pp. 12471-12476
6-PHENYL-6-ALKYLAMIDO-5,6-DIHYDRO-2H-PYRAN-2-ONES - NOVEL HIV PROTEASE INHIBITORS
Authors: HAMILTON HW TAIT BD GAJDA C HAGEN SE FERGUSON D LUNNEY EA PAVLOVSKY A TUMMINO PJ
Citation: Hw. Hamilton et al., 6-PHENYL-6-ALKYLAMIDO-5,6-DIHYDRO-2H-PYRAN-2-ONES - NOVEL HIV PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 6(6), 1996, pp. 719-724
NOVEL PHOSPHOTYROSINE MIMETICS IN THE DESIGN OF PEPTIDE LIGANDS FOR PP60(SRC) SH2 DOMAIN
Authors: SHAHRIPOUR A PLUMMER MS LUNNEY EA PARA KS STANKOVIC CJ RUBIN JR HUMBLET C FERGUS JH MARKS JS HERRERA R HUBBELL SE SALTIEL AR SAWYER TK
Citation: A. Shahripour et al., NOVEL PHOSPHOTYROSINE MIMETICS IN THE DESIGN OF PEPTIDE LIGANDS FOR PP60(SRC) SH2 DOMAIN, Bioorganic & medicinal chemistry letters, 6(11), 1996, pp. 1209-1214
A TOPLISS TREE ANALYSIS OF THE HIV-PROTEASE INHIBITORY ACTIVITY OF 6-PHENYL-4-HYDROXY-PYRAN-2-ONES
Authors: STEINBAUGH BA HAMILTON HW PRASAD JVNV PARA KS TUMMINO PJ FERGUSON D LUNNEY EA BLANKLEY CJ
Citation: Ba. Steinbaugh et al., A TOPLISS TREE ANALYSIS OF THE HIV-PROTEASE INHIBITORY ACTIVITY OF 6-PHENYL-4-HYDROXY-PYRAN-2-ONES, Bioorganic & medicinal chemistry letters, 6(10), 1996, pp. 1099-1104
AN ALPHA-MERCAPTOACRYLIC ACID-DERIVATIVE IS A SELECTIVE NONPEPTIDE CELL-PERMEABLE CALPAIN INHIBITOR AND IS NEUROPROTECTIVE
Authors: WANG KKW NATH R POSNER A RASER KJ BUROKERKILGORE M HAJIMOHAMMADREZA I PROBERT AW MARCOUX FW YE QH TAKANO E HATANAKA M MAKI M CANER H COLLINS JL FERGUS A LEE KS LUNNEY EA HAYS SJ YUEN PW
Citation: Kkw. Wang et al., AN ALPHA-MERCAPTOACRYLIC ACID-DERIVATIVE IS A SELECTIVE NONPEPTIDE CELL-PERMEABLE CALPAIN INHIBITOR AND IS NEUROPROTECTIVE, Proceedings of the National Academy of Sciences of the United Statesof America, 93(13), 1996, pp. 6687-6692
NONPEPTIDIC HIV PROTEASE INHIBITORS - 4-HYDROXY-PYRAN-2-ONE INHIBITORS WITH FUNCTIONAL TETHERS TO P-1 PHENYL RING TO REACH S-3 POCKET OF THE ENZYME
Authors: PRASAD JVNV TUMMINO PJ FERGUSON D SAUNDERS J VANDERROEST S MCQUADE TJ HELDSINGER A REYNER EL STEWART BH GUTTENDORF RJ PARA KS LUNNEY EA GRACHECK SJ DOMAGALA JM
Citation: Jvnv. Prasad et al., NONPEPTIDIC HIV PROTEASE INHIBITORS - 4-HYDROXY-PYRAN-2-ONE INHIBITORS WITH FUNCTIONAL TETHERS TO P-1 PHENYL RING TO REACH S-3 POCKET OF THE ENZYME, Biochemical and biophysical research communications, 221(3), 1996, pp. 815-820
NONPEPTIDIC POTENT HIV-1 PROTEASE INHIBITORS - -HYDROXY-6-PHENYL-2-OXO-2H-PYRAN-3-YL)THIOMETHANES THAT SPAN P-1-P-2' SUBSITES IN A UNIQUE MODE OF ACTIVE-SITE BINDING
Authors: PRASAD JVN PARA KS TUMMINO PJ FERGUSON D MCQUADE TJ LUNNEY EA RAPUNDALO ST BATLEY BL HINGORANI G DOMAGALA JM GRACHECK SJ BHAT TN LIU BS BALDWIN ET ERICKSON JW SAWYER TK
Citation: Jvn. Prasad et al., NONPEPTIDIC POTENT HIV-1 PROTEASE INHIBITORS - -HYDROXY-6-PHENYL-2-OXO-2H-PYRAN-3-YL)THIOMETHANES THAT SPAN P-1-P-2' SUBSITES IN A UNIQUE MODE OF ACTIVE-SITE BINDING, Journal of medicinal chemistry, 38(6), 1995, pp. 898-905
DESIGN AND SYNTHESIS OF RENIN INHIBITORS - INCORPORATION OF TRANSITION-STATE ISOSTERE SIDE-CHAINS THAT SPAN FROM THE S1 TO THE S3 BINDING POCKETS AND EXAMINATION OF P3-MODIFIED RENIN INHIBITORS
Authors: PLUMMER MS SHAHRIPOUR A KALTENBRONN JS LUNNEY EA STEINBAUGH BA HAMBY JM HAMILTON HW SAWYER TK HUMBLET C DOHERTY AM TAYLOR MD HINGORANI G BATLEY BL RAPUNDALO ST
Citation: Ms. Plummer et al., DESIGN AND SYNTHESIS OF RENIN INHIBITORS - INCORPORATION OF TRANSITION-STATE ISOSTERE SIDE-CHAINS THAT SPAN FROM THE S1 TO THE S3 BINDING POCKETS AND EXAMINATION OF P3-MODIFIED RENIN INHIBITORS, Journal of medicinal chemistry, 38(15), 1995, pp. 2893-2905
HIV PROTEASE INHIBITORS POSSESSING A NOVEL, HIGH-AFFINITY, AND ACHIRAL P-1' P-2' LIGAND WITH A UNIQUE PATTERN OF IN-VITRO RESISTANCE - IMPORTANCE OF A CONFORMATIONALLY-RESTRICTED TEMPLATE IN THE DESIGN OF ENZYME-INHIBITORS/
Authors: PRASAD JVNV LUNNEY EA FERGUSON D TUMMINO PJ RUBIN JR REYNER EL STEWART BH GUTTENDORF RJ DOMAGALA JM SUVOROV LI GULNIK SV TOPOL IA BHAT TN ERICKSON JW
Citation: Jvnv. Prasad et al., HIV PROTEASE INHIBITORS POSSESSING A NOVEL, HIGH-AFFINITY, AND ACHIRAL P-1' P-2' LIGAND WITH A UNIQUE PATTERN OF IN-VITRO RESISTANCE - IMPORTANCE OF A CONFORMATIONALLY-RESTRICTED TEMPLATE IN THE DESIGN OF ENZYME-INHIBITORS/, Journal of the American Chemical Society, 117(45), 1995, pp. 11070-11074
TETRAHYDROISOQUINOLINE AS A PHENYLALANINE REPLACEMENT IN RENIN INHIBITORS
Authors: STEINBAUGH BA HAMILTON HW PATT WC RAPUNDALO ST BATLEY BL LUNNEY EA RYAN MJ HICKS GW
Citation: Ba. Steinbaugh et al., TETRAHYDROISOQUINOLINE AS A PHENYLALANINE REPLACEMENT IN RENIN INHIBITORS, Bioorganic & medicinal chemistry letters, 4(16), 1994, pp. 2029-2034
CRYSTAL-STRUCTURES OF 2 RATIONALLY SELECTED, STRUCTURALLY NOVEL HIV-1PROTEASE INHIBITORS - COMPARISONS WITH MODELING
Authors: THANKI N HUMBLET CC LUNNEY EA WLODAWER A
Citation: N. Thanki et al., CRYSTAL-STRUCTURES OF 2 RATIONALLY SELECTED, STRUCTURALLY NOVEL HIV-1PROTEASE INHIBITORS - COMPARISONS WITH MODELING, Journal of cellular biochemistry, 1994, pp. 175-175
MEMORIES OF METALLOTHIONEIN
Authors: KILLE P HEMMINGS A LUNNEY EA
Citation: P. Kille et al., MEMORIES OF METALLOTHIONEIN, Biochimica et biophysica acta. Protein structure and molecular enzymology, 1205(2), 1994, pp. 151-161
A NOVEL NONPEPTIDE HIV-1 PROTEASE INHIBITOR - ELUCIDATION OF THE BINDING MODE AND ITS APPLICATION IN THE DESIGN OF RELATED ANALOGS
Authors: LUNNEY EA HAGEN SE DOMAGALA JM HUMBLET C KOSINSKI J TAIT BD WARMUS JS WILSON M FERGUSON D HUPE D TUMMINO PJ BALDWIN ET BHAT TN LIU BS ERICKSON JW
Citation: Ea. Lunney et al., A NOVEL NONPEPTIDE HIV-1 PROTEASE INHIBITOR - ELUCIDATION OF THE BINDING MODE AND ITS APPLICATION IN THE DESIGN OF RELATED ANALOGS, Journal of medicinal chemistry, 37(17), 1994, pp. 2664-2677
NOVEL SERIES OF ACHIRAL, LOW-MOLECULAR-WEIGHT, AND POTENT HIV-1 PROTEASE INHIBITORS
Authors: PRASAD JVNV PARA KS LUNNEY EA ORTWINE DF DUNBAR JB FERGUSON D TUMMINO PJ HUPE D TAIT BD DOMAGALA JM HUMBLET C BHAT TN LIU BS GUERIN DMA BALDWIN ET ERICKSON JW SAWYER TK
Citation: Jvnv. Prasad et al., NOVEL SERIES OF ACHIRAL, LOW-MOLECULAR-WEIGHT, AND POTENT HIV-1 PROTEASE INHIBITORS, Journal of the American Chemical Society, 116(15), 1994, pp. 6989-6990
CHARACTERIZATION OF 2 STRUCTURALLY NOVEL HIV-1 PROTEASE INHIBITORS IDENTIFIED BY RATIONAL SELECTION
Authors: HUMBLET CC LUNNEY EA BUCKHEIT RW DOGGETT C WONG R ANTONUCCI TK
Citation: Cc. Humblet et al., CHARACTERIZATION OF 2 STRUCTURALLY NOVEL HIV-1 PROTEASE INHIBITORS IDENTIFIED BY RATIONAL SELECTION, Antiviral research, 21(1), 1993, pp. 73-84
ANALYSES OF LIGAND-BINDING IN 5 ENDOTHIAPEPSIN CRYSTAL COMPLEXES AND THEIR USE IN THE DESIGN AND EVALUATION OF NOVEL RENIN INHIBITORS
Authors: LUNNEY EA HAMILTON HW HODGES JC KALTENBRONN JS REPINE JT BADASSO M COOPER JB DEALWIS C WALLACE BA LOWTHER WT DUNN BM HUMBLET C
Citation: Ea. Lunney et al., ANALYSES OF LIGAND-BINDING IN 5 ENDOTHIAPEPSIN CRYSTAL COMPLEXES AND THEIR USE IN THE DESIGN AND EVALUATION OF NOVEL RENIN INHIBITORS, Journal of medicinal chemistry, 36(24), 1993, pp. 3809-3820
SPECIFICITY IN THE BINDING OF INHIBITORS TO THE ACTIVE-SITE OF HUMAN PRIMATE ASPARTIC PROTEINASES - ANALYSIS OF P2-P1-P1'-P2' VARIATION
Authors: RAO CM SCARBOROUGH PE KAY J BATLEY B RAPUNDALO S KLUTCHKO S TAYLOR MD LUNNEY EA HUMBLET CC DUNN BM
Citation: Cm. Rao et al., SPECIFICITY IN THE BINDING OF INHIBITORS TO THE ACTIVE-SITE OF HUMAN PRIMATE ASPARTIC PROTEINASES - ANALYSIS OF P2-P1-P1'-P2' VARIATION, Journal of medicinal chemistry, 36(18), 1993, pp. 2614-2620
RENIN INHIBITORS CONTAINING ALPHA-HETEROATOM AMINO-ACIDS AS P2 RESIDUES
Authors: REPINE JT KALTENBRONN JS DOHERTY AM HAMBY JM HIMMELSBACH RJ KORNBERG BE TAYLOR MD LUNNEY EA HUMBLET C RAPUNDALO ST BATLEY BL RYAN MJ PAINCHAUD CA
Citation: Jt. Repine et al., RENIN INHIBITORS CONTAINING ALPHA-HETEROATOM AMINO-ACIDS AS P2 RESIDUES, Journal of medicinal chemistry, 35(6), 1992, pp. 1032-1042
Risultati: 1-23 |