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Results: 1-25 | 26-29
Results: 1-25/29
PYRROLES AND OTHER HETEROCYCLES AS INHIBITORS OF P38 KINASE
Authors: DELASZLO SE VISCO D AGARWAL L CHANG L CHIN J CROFT G FORSYTH A FLETCHER D FRANTZ B HACKER C HANLON W HARPER C KOSTURA M LI B LUELL S MACCOSS M MANTLO N ONEILL EA OREVILLO C PANG M PARSONS J ROLANDO A SAHLY Y SIDLER K WIDMER WR OKEEFE SJ
Citation: Se. Delaszlo et al., PYRROLES AND OTHER HETEROCYCLES AS INHIBITORS OF P38 KINASE, Bioorganic & medicinal chemistry letters, 8(19), 1998, pp. 2689-2694
L-TRYPTOPHAN UREA AMIDES AS NK1 NK2 DUAL ANTAGONISTS/
Authors: QI HB SHAH SK CASCIERI MA SADOWSKI SJ MACCOSS M
Citation: Hb. Qi et al., L-TRYPTOPHAN UREA AMIDES AS NK1 NK2 DUAL ANTAGONISTS/, Bioorganic & medicinal chemistry letters, 8(16), 1998, pp. 2259-2262
DISTINCT MECHANISM FOR ANTIDEPRESSANT ACTIVITY BY BLOCKADE OF CENTRALSUBSTANCE-P RECEPTORS
Authors: KRAMER MS CUTLER N FEIGHNER J SHRIVASTAVA R CARMAN J SRAMEK JJ REINES SA LIU GH SNAVELY D WYATTKNOWLES E HALE JJ MILLS SG MACCOSS M SWAIN CJ HARRISON T HILL RG HEFTI F SCOLNICK EM CASCIERI MA CHICCHI GG SADOWSKI S WILLIAMS AR HEWSON L SMITH D CARLSON EJ HARGREAVES RJ RUPNIAK NMJ
Citation: Ms. Kramer et al., DISTINCT MECHANISM FOR ANTIDEPRESSANT ACTIVITY BY BLOCKADE OF CENTRALSUBSTANCE-P RECEPTORS, Science, 281(5383), 1998, pp. 1640-1645
STRUCTURAL OPTIMIZATION AFFORDING ENYL-4-(3-OXO-1,2,4-TRIAZOL-5-YL)METHYLMORPHOLINE, A POTENT, ORALLY-ACTIVE, LONG-ACTING MORPHOLINE ACETALHUMAN NK-1 RECEPTOR ANTAGONIST
Authors: HALE JJ MILLS SG MACCOSS M FINKE PE CASCIERI MA SADOWSKI S BER E CHICCHI GG KURTZ M METZGER J EIERMANN G TSOU NN TATTERSALL FD RUPNIAK NMJ WILLIAMS AR RYCROFT W HARGREAVES R MACINTYRE DE
Citation: Jj. Hale et al., STRUCTURAL OPTIMIZATION AFFORDING ENYL-4-(3-OXO-1,2,4-TRIAZOL-5-YL)METHYLMORPHOLINE, A POTENT, ORALLY-ACTIVE, LONG-ACTING MORPHOLINE ACETALHUMAN NK-1 RECEPTOR ANTAGONIST, Journal of medicinal chemistry, 41(23), 1998, pp. 4607-4614
INHIBITION OF NITRIC-OXIDE SYNTHASE BY BENZOXAZOLONES
Authors: SHANKARAN K DONNELLY KL SHAH SK HUMES JL PACHOLOK SG GRANT SK GREEN BG MACCOSS M
Citation: K. Shankaran et al., INHIBITION OF NITRIC-OXIDE SYNTHASE BY BENZOXAZOLONES, Bioorganic & medicinal chemistry letters, 7(22), 1997, pp. 2887-2892
IN-VITRO AND IN-VIVO PREDICTORS OF THE ANTIEMETIC ACTIVITY OF TACHYKININ NK1 RECEPTOR ANTAGONISTS
Authors: RUPNIAK NMJ TATTERSALL FD WILLIAMS AR RYCROFT W CARLSON EJ CASCIERI MA SADOWSKI S BER E HALE JJ MILLS SG MACCOSS M SEWARD E HUSCROFT I OWEN S SWAIN CJ HILL RG HARGREAVES RJ
Citation: Nmj. Rupniak et al., IN-VITRO AND IN-VIVO PREDICTORS OF THE ANTIEMETIC ACTIVITY OF TACHYKININ NK1 RECEPTOR ANTAGONISTS, European journal of pharmacology, 326(2-3), 1997, pp. 201-209
CHARACTERIZATION OF THE BINDING AND ACTIVITY OF A HIGH-AFFINITY, PSEUDOIRREVERSIBLE MORPHOLINO TACHYKININ NK1 RECEPTOR ANTAGONIST
Authors: CASCIERI MA BER E FONG TM HALE JJ TANG F SHIAO LL MILLS SG MACCOSS M SADOWSKI S TOTA MR STRADER CD
Citation: Ma. Cascieri et al., CHARACTERIZATION OF THE BINDING AND ACTIVITY OF A HIGH-AFFINITY, PSEUDOIRREVERSIBLE MORPHOLINO TACHYKININ NK1 RECEPTOR ANTAGONIST, European journal of pharmacology, 325(2-3), 1997, pp. 253-261
PREDICTION OF THE ANTIEMETIC ACTIVITY OF NK1 RECEPTOR ANTAGONISTS IN FERRETS BY THEIR ABILITY TO INHIBIT GR73632-INDUCED FOOT TAPPING IN GERBILS
Authors: RUPNIAK NMJ TATTERSALL FD WILLIAMS AR RYCROFT W CARLSON EJ CASCIERI MA HALE JJ MILLS SG MACCOSS M SEWARD E HUSCROFT I SWAIN CJ HILL RG HARGREAVES RJ
Citation: Nmj. Rupniak et al., PREDICTION OF THE ANTIEMETIC ACTIVITY OF NK1 RECEPTOR ANTAGONISTS IN FERRETS BY THEIR ABILITY TO INHIBIT GR73632-INDUCED FOOT TAPPING IN GERBILS, British Journal of Pharmacology, 120, 1997, pp. 363-363
ORALLY-ACTIVE INHIBITORS OF STROMELYSIN-1 (MMP-3)
Authors: CHAPMAN KT DURETTE PL CALDWELL CG SPEROW KM NIEDZWIECKI LM HARRISON RK SAPHOS C CHRISTEN AJ OLSZEWSKI JM MOORE VL MACCOSS M HAGMANN WK
Citation: Kt. Chapman et al., ORALLY-ACTIVE INHIBITORS OF STROMELYSIN-1 (MMP-3), Bioorganic & medicinal chemistry letters, 6(7), 1996, pp. 803-806
NYL-4-((3-OXO-1,2,4-TRIAZOL-5-YL)METHYL)MORPHOLINE .1. A POTENT, ORALLY-ACTIVE, MORPHOLINE-BASED HUMAN NEUROKININ-1 RECEPTOR ANTAGONIST
Authors: HALE JJ MILLS SG MACCOSS M SHAH SK QI HB MATHRE DJ CASCIERI MA SADOWSKI S STRADER CD MACINTYRE DE METZGER JM
Citation: Jj. Hale et al., NYL-4-((3-OXO-1,2,4-TRIAZOL-5-YL)METHYL)MORPHOLINE .1. A POTENT, ORALLY-ACTIVE, MORPHOLINE-BASED HUMAN NEUROKININ-1 RECEPTOR ANTAGONIST, Journal of medicinal chemistry, 39(9), 1996, pp. 1760-1762
EXPRESSION AND IMMUNOAFFINITY PURIFICATION OF HUMAN INDUCIBLE NITRIC-OXIDE SYNTHASE - INHIBITION STUDIES WITH 2-AMINO-5,6-DIHYDRO-4H-1,3-THIAZINE
Authors: CALAYCAY JR KELLY TM MACNAUL KL MCCAULEY ED QI HB GRANT SK GRIFFIN PR KLATT T RAJU SM NUSSLER AK SHAH S WEIDNER JR WILLIAMS HR WOLFE GC GELLER DA BILLIAR TR MACCOSS M MUMFORD RA TOCCI MJ SCHMIDT JA WONG KK HUTCHINSON NI
Citation: Jr. Calaycay et al., EXPRESSION AND IMMUNOAFFINITY PURIFICATION OF HUMAN INDUCIBLE NITRIC-OXIDE SYNTHASE - INHIBITION STUDIES WITH 2-AMINO-5,6-DIHYDRO-4H-1,3-THIAZINE, The Journal of biological chemistry, 271(45), 1996, pp. 28212-28219
1,2,4-TRIACYLPIPERIDINE SUBSTANCE-P ANTAGONISTS - SEPARATION OF AFFINITIES FOR THE NK-1 RECEPTOR AND THE L-TYPE CALCIUM-CHANNEL
Authors: MILLS SG MACCOSS M CASCIERI MA SADOWSKI S PATEL S CHAPMAN KL HUTSON PH
Citation: Sg. Mills et al., 1,2,4-TRIACYLPIPERIDINE SUBSTANCE-P ANTAGONISTS - SEPARATION OF AFFINITIES FOR THE NK-1 RECEPTOR AND THE L-TYPE CALCIUM-CHANNEL, Bioorganic & medicinal chemistry letters, 5(6), 1995, pp. 599-604
PHOSPHORUS-ACID ANALOGS OF L-680,833, A POTENT MONOCYCLIC BETA-LACTAMINHIBITOR OF HUMAN-LEUKOCYTE ELASTASE
Authors: DURETTE PL CHABIN RM FLETCHER DS GREEN BG HANLON WA HUMES JL KNIGHT WB LANZA TJ MUMFORD RA PACHOLOK S MACCOSS M
Citation: Pl. Durette et al., PHOSPHORUS-ACID ANALOGS OF L-680,833, A POTENT MONOCYCLIC BETA-LACTAMINHIBITOR OF HUMAN-LEUKOCYTE ELASTASE, Bioorganic & medicinal chemistry letters, 5(3), 1995, pp. 271-274
INHIBITION OF MATRIX METALLOPROTEINASES BY N-CARBOXYALKYL DIPEPTIDES - ENHANCED POTENCY AND SELECTIVITY WITH SUBSTITUTED P-1' HOMOPHENYLALANINES
Authors: SAHOO SP CALDWELL CG CHAPMAN KT DURETTE PL ESSER CK KOPKA IE POLO SA SPEROW KM NIEDZWIECKI LM IZQUIERDOMARTIN M CHANG BC HARRISON RK STEIN RL MACCOSS M HAGMANN WK
Citation: Sp. Sahoo et al., INHIBITION OF MATRIX METALLOPROTEINASES BY N-CARBOXYALKYL DIPEPTIDES - ENHANCED POTENCY AND SELECTIVITY WITH SUBSTITUTED P-1' HOMOPHENYLALANINES, Bioorganic & medicinal chemistry letters, 5(20), 1995, pp. 2441-2446
1,2,3-TRISUBSTITUTED CYCLOHEXYL SUBSTANCE-P ANTAGONISTS - SIGNIFICANCE OF THE RING NITROGEN IN PIPERIDINE-BASED NK-1 RECEPTOR ANTAGONISTS
Authors: MILLS SG MACCOSS M UNDERWOOD D SHAH SK FINKE PE MILLER DJ BUDHU RJ CASCIERI MA SADOWSKI S STRADER CD
Citation: Sg. Mills et al., 1,2,3-TRISUBSTITUTED CYCLOHEXYL SUBSTANCE-P ANTAGONISTS - SIGNIFICANCE OF THE RING NITROGEN IN PIPERIDINE-BASED NK-1 RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 5(13), 1995, pp. 1345-1350
INHIBITION OF INTERLEUKIN-1-BETA CONVERTING-ENZYME BY N-ACYL-ASPARTICACID KETONES
Authors: MJALLI AMM CHAPMAN KT ZHAO JJ THORNBERRY NA PETERSON EP MACCOSS M
Citation: Amm. Mjalli et al., INHIBITION OF INTERLEUKIN-1-BETA CONVERTING-ENZYME BY N-ACYL-ASPARTICACID KETONES, Bioorganic & medicinal chemistry letters, 5(13), 1995, pp. 1405-1408
INHIBITION OF INTERLEUKIN-1-BETA CONVERTING-ENZYME BY N-ACYL-ASPARTYLARYLOXYMETHYL KETONES
Authors: MJALLI AMM ZHAO JJ CHAPMAN KT THORNBERRY NA PETERSON EP MACCOSS M HAGMANN WK
Citation: Amm. Mjalli et al., INHIBITION OF INTERLEUKIN-1-BETA CONVERTING-ENZYME BY N-ACYL-ASPARTYLARYLOXYMETHYL KETONES, Bioorganic & medicinal chemistry letters, 5(13), 1995, pp. 1409-1414
CHARACTERIZATION OF THE INTERACTION OF DIACYLPIPERAZINE ANTAGONISTS WITH THE HUMAN NEUROKININ-1 RECEPTOR - IDENTIFICATION OF A COMMON BINDING-SITE FOR STRUCTURALLY DISSIMILAR ANTAGONISTS
Authors: CASCIERI MA SHIAO LL MILLS SG MACCOSS M SWAIN CJ YU H BER E SADOWSKI S WU MT STRADER CD FONG TM
Citation: Ma. Cascieri et al., CHARACTERIZATION OF THE INTERACTION OF DIACYLPIPERAZINE ANTAGONISTS WITH THE HUMAN NEUROKININ-1 RECEPTOR - IDENTIFICATION OF A COMMON BINDING-SITE FOR STRUCTURALLY DISSIMILAR ANTAGONISTS, Molecular pharmacology, 47(4), 1995, pp. 660-665
MECHANISM OF INHIBITION OF HUMAN-LEUKOCYTE ELASTASE BY BETA-LACTAMS .2. STABILITY, REACTIVATION KINETICS, AND PRODUCTS OF BETA-LACTAM-DERIVED E-I COMPLEXES
Authors: GREEN BG CHABIN R MILLS S UNDERWOOD DJ SHAH SK KUO D GALE P MAYCOCK AL LIESCH J BURGEY CS DOHERTY JB DORN CP FINKE PE HAGMANN WK HALE JJ MACCOSS M WESTLER WM KNIGHT WB
Citation: Bg. Green et al., MECHANISM OF INHIBITION OF HUMAN-LEUKOCYTE ELASTASE BY BETA-LACTAMS .2. STABILITY, REACTIVATION KINETICS, AND PRODUCTS OF BETA-LACTAM-DERIVED E-I COMPLEXES, Biochemistry, 34(44), 1995, pp. 14331-14343
MECHANISM OF INHIBITION OF HUMAN-LEUKOCYTE ELASTASE BY BETA-LACTAMS .3. USE OF ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY AND 2-DIMENSIONAL NMR TECHNIQUES TO IDENTIFY BETA-LACTAM-DERIVED E-I-COMPLEXES
Authors: UNDERWOOD DJ GREEN BG CHABIN R MILLS S DOHERTY JB FINKE PE MACCOSS M SHAH SK BURGEY CS DICKINSON TA GRIFFIN PR LEE TE SWIDEREK KM COVEY T WESTLER WM KNIGHT WB
Citation: Dj. Underwood et al., MECHANISM OF INHIBITION OF HUMAN-LEUKOCYTE ELASTASE BY BETA-LACTAMS .3. USE OF ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY AND 2-DIMENSIONAL NMR TECHNIQUES TO IDENTIFY BETA-LACTAM-DERIVED E-I-COMPLEXES, Biochemistry, 34(44), 1995, pp. 14344-14355
ACTIVATED KETONES AS POTENT REVERSIBLE INHIBITORS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME
Authors: MJALLI AMM CHAPMAN KT MACCOSS M THORNBERRY NA PETERSON EP
Citation: Amm. Mjalli et al., ACTIVATED KETONES AS POTENT REVERSIBLE INHIBITORS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME, Bioorganic & medicinal chemistry letters, 4(16), 1994, pp. 1965-1968
SYNTHESIS OF NEW IMIDAZO[1,2-B]PYRIDAZINE ISOSTERES OF POTENT IMIDAZO[4,5-B]PYRIDINE ANGIOTENSIN-II ANTAGONISTS
Authors: WALSH TF FITCH KJ MACCOSS M CHANG RSL KIVLIGHN SD LOTTI VJ SIEGL PKS PATCHETT AA GREENLEE WJ
Citation: Tf. Walsh et al., SYNTHESIS OF NEW IMIDAZO[1,2-B]PYRIDAZINE ISOSTERES OF POTENT IMIDAZO[4,5-B]PYRIDINE ANGIOTENSIN-II ANTAGONISTS, Bioorganic & medicinal chemistry letters, 4(1), 1994, pp. 219-222
PHENYLALKYL KETONES AS POTENT REVERSIBLE INHIBITORS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME
Authors: MJALLI AMM CHAPMAN KT MACCOSS M THORNBERRY NA
Citation: Amm. Mjalli et al., PHENYLALKYL KETONES AS POTENT REVERSIBLE INHIBITORS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2689-2692
SYNTHESIS OF A PEPTIDYL 2,2-DIFLUORO-4-PHENYLBUTYL KETONE AND ITS EVALUATION AS AN INHIBITOR OF INTERLEUKIN-1-BETA CONVERTING-ENZYME
Authors: MJALLI AMM CHAPMAN KT MACCOSS M
Citation: Amm. Mjalli et al., SYNTHESIS OF A PEPTIDYL 2,2-DIFLUORO-4-PHENYLBUTYL KETONE AND ITS EVALUATION AS AN INHIBITOR OF INTERLEUKIN-1-BETA CONVERTING-ENZYME, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2693-2698
IACYLPIPERAZINE-2-(S)-[(N-AMINOALKYL)CARBOXAMIDES] AS NOVEL, POTENT SUBSTANCE-P RECEPTOR ANTAGONISTS
Authors: MILLS SG WU MT MACCOSS M BUDHU RJ DORN CP CASCIERI MA SADOWSKI S STRADER CD GREENLEE WJ
Citation: Sg. Mills et al., IACYLPIPERAZINE-2-(S)-[(N-AMINOALKYL)CARBOXAMIDES] AS NOVEL, POTENT SUBSTANCE-P RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2707-2712
Risultati: 1-25 | 26-29