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Results: 1-20 |
Results: 20
STRUCTURE-BASED DESIGN AND SYNTHESIS OF A SERIES OF HYDROXAMIC ACIDS WITH A QUATERNARY-HYDROXY GROUP IN P1 AS INHIBITORS OF MATRIX METALLOPROTEINASES
Authors: JACOBSON IC REDDY PG WASSERMAN ZR HARDMAN KD COVINGTON MB ARNER EC COPELAND RA DECICCO CP MAGOLDA RL
Citation: Ic. Jacobson et al., STRUCTURE-BASED DESIGN AND SYNTHESIS OF A SERIES OF HYDROXAMIC ACIDS WITH A QUATERNARY-HYDROXY GROUP IN P1 AS INHIBITORS OF MATRIX METALLOPROTEINASES, Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 837-842
STRUCTURE-ACTIVITY-RELATIONSHIPS (SAR) OF SOME TETRACYCLIC HETEROCYCLES RELATED TO THE IMMUNOSUPPRESSIVE AGENT BREQUINAR SODIUM
Authors: PITTS WJ JETTER JW PINTO DJ ORWAT MJ BATT DG SHERK SR PETRAITIS JJ JACOBSON IC COPELAND RA DOWLING RL JAFFEE BD GARDNER TL JONES EA MAGOLDA RL
Citation: Wj. Pitts et al., STRUCTURE-ACTIVITY-RELATIONSHIPS (SAR) OF SOME TETRACYCLIC HETEROCYCLES RELATED TO THE IMMUNOSUPPRESSIVE AGENT BREQUINAR SODIUM, Bioorganic & medicinal chemistry letters, 8(3), 1998, pp. 307-312
MEK INHIBITORS - THE CHEMISTRY AND BIOLOGICAL-ACTIVITY OF U0126, ITS ANALOGS, AND CYCLIZATION PRODUCTS
Authors: DUNCIA JV SANTELLA JB HIGLEY CA PITTS WJ WITYAK J FRIETZE WE RANKIN FW SUN JH EARL RA TABAKA AC TELEHA CA BLOM KF FAVATA MF MANOS EJ DAULERIO AJ STRADLEY DA HORIUCHI K COPELAND RA SCHERLE PA TRZASKOS JM MAGOLDA RL TRAINOR GL WEXLER RR HOBBS FW OLSON RE
Citation: Jv. Duncia et al., MEK INHIBITORS - THE CHEMISTRY AND BIOLOGICAL-ACTIVITY OF U0126, ITS ANALOGS, AND CYCLIZATION PRODUCTS, Bioorganic & medicinal chemistry letters, 8(20), 1998, pp. 2839-2844
HETEROATOM-LINKED AND CARBON-LINKED BIPHENYL ANALOGS OF BREQUINAR AS IMMUNOSUPPRESSIVE AGENTS
Authors: BATT DG PETRAITIS JJ SHERK SR COPELAND RA DOWLING RL TAYLOR TL JONES EA MAGOLDA RL JAFFEE BD
Citation: Dg. Batt et al., HETEROATOM-LINKED AND CARBON-LINKED BIPHENYL ANALOGS OF BREQUINAR AS IMMUNOSUPPRESSIVE AGENTS, Bioorganic & medicinal chemistry letters, 8(13), 1998, pp. 1745-1750
INHIBITION OF MAP KINASE KINASE PREVENTS CYTOKINE AND PROSTAGLANDIN E-2 PRODUCTION IN LIPOPOLYSACCHARIDE-STIMULATED MONOCYTES
Authors: SCHERLE PA JONES EA FAVATA MF DAULERIO AJ COVINGTON MB NURNBERG SA MAGOLDA RL TRZASKOS JM
Citation: Pa. Scherle et al., INHIBITION OF MAP KINASE KINASE PREVENTS CYTOKINE AND PROSTAGLANDIN E-2 PRODUCTION IN LIPOPOLYSACCHARIDE-STIMULATED MONOCYTES, The Journal of immunology (1950), 161(10), 1998, pp. 5681-5686
INHIBITION OF MITOGEN-ACTIVATED PROTEIN-KINASE KINASE BLOCKS T-CELL PROLIFERATION BUT DOES NOT INDUCE OR PREVENT ANERGY
Authors: DESILVA DR JONES EA FAVATA MF JAFFEE BD MAGOLDA RL TRZASKOS JM SCHERLE PA
Citation: Dr. Desilva et al., INHIBITION OF MITOGEN-ACTIVATED PROTEIN-KINASE KINASE BLOCKS T-CELL PROLIFERATION BUT DOES NOT INDUCE OR PREVENT ANERGY, The Journal of immunology, 160(9), 1998, pp. 4175-4181
IDENTIFICATION OF A NOVEL INHIBITOR OF MITOGEN-ACTIVATED PROTEIN-KINASE KINASE
Authors: FAVATA MF HORIUCHI KY MANOS EJ DAULERIO AJ STRADLEY DA FEESER WS VANDYK DE PITTS WJ EARL RA HOBBS F COPELAND RA MAGOLDA RL SCHERLE PA TRZASKOS JM
Citation: Mf. Favata et al., IDENTIFICATION OF A NOVEL INHIBITOR OF MITOGEN-ACTIVATED PROTEIN-KINASE KINASE, The Journal of biological chemistry, 273(29), 1998, pp. 18623-18632
AMIDE SURROGATES OF MATRIX METALLOPROTEINASE INHIBITORS - UREA AND SULFONAMIDE MIMICS
Authors: DECICCO CP SENG JL KENNEDY KE COVINGTON MB WELCH PK ARNER EC MAGOLDA RL NELSON DJ
Citation: Cp. Decicco et al., AMIDE SURROGATES OF MATRIX METALLOPROTEINASE INHIBITORS - UREA AND SULFONAMIDE MIMICS, Bioorganic & medicinal chemistry letters, 7(18), 1997, pp. 2331-2336
COMPARISON OF SNAKE-VENOM REPROLYSIN AND MATRIX METALLOPROTEINASES ASMODELS OF TNF-ALPHA CONVERTING-ENZYME
Authors: VANDYK DE MARCHAND P BRUCKNER RC FOX JW JAFFEE BD GUNYUZLU PL DAVIS GL NURNBERG S COVINGTON M DECICCO CP TRZASKOS JM MAGOLDA RL COPELAND RA
Citation: De. Vandyk et al., COMPARISON OF SNAKE-VENOM REPROLYSIN AND MATRIX METALLOPROTEINASES ASMODELS OF TNF-ALPHA CONVERTING-ENZYME, Bioorganic & medicinal chemistry letters, 7(10), 1997, pp. 1219-1224
CHEMISTRY AND PHARMACOKINETICS OF DIARYLTHIOPHENES AND TERPHENYLS AS SELECTIVE COX-2 INHIBITORS
Authors: PINTO DJP COPELAND RA COVINGTON MB PITTS WJ BATT DG ORWAT MJ LAM GN JOSHI A CHAN YC WANG S TRZASKOS JM MAGOLDA RL KORNHAUSER DM
Citation: Djp. Pinto et al., CHEMISTRY AND PHARMACOKINETICS OF DIARYLTHIOPHENES AND TERPHENYLS AS SELECTIVE COX-2 INHIBITORS, Bioorganic & medicinal chemistry letters, 6(24), 1996, pp. 2907-2912
THE IMMUNOSUPPRESSIVE METABOLITE OF LEFLUNOMIDE IS A POTENT INHIBITOROF HUMAN DIHYDROOROTATE DEHYDROGENASE
Authors: DAVIS IP CAIN GA PITTS WI MAGOLDA RL COPELAND RA
Citation: Ip. Davis et al., THE IMMUNOSUPPRESSIVE METABOLITE OF LEFLUNOMIDE IS A POTENT INHIBITOROF HUMAN DIHYDROOROTATE DEHYDROGENASE, The FASEB journal, 10(6), 1996, pp. 23-23
ISOTHIAZOLONES INTERFERE WITH NORMAL MATRIX METALLOPROTEINASE ACTIVATION AND INHIBIT CARTILAGE PROTEOGLYCAN DEGRADATION
Authors: ARNER EC PRATTA MA FREIMARK B LISCHWE M TRZASKOS JM MAGOLDA RL WRIGHT SW
Citation: Ec. Arner et al., ISOTHIAZOLONES INTERFERE WITH NORMAL MATRIX METALLOPROTEINASE ACTIVATION AND INHIBIT CARTILAGE PROTEOGLYCAN DEGRADATION, Biochemical journal, 318, 1996, pp. 417-424
THE IMMUNOSUPPRESSIVE METABOLITE OF LEFLUNOMIDE IS A POTENT INHIBITOROF HUMAN DIHYDROOROTATE DEHYDROGENASE
Authors: DAVIS JP CAIN GA PITTS WJ MAGOLDA RL COPELAND RA
Citation: Jp. Davis et al., THE IMMUNOSUPPRESSIVE METABOLITE OF LEFLUNOMIDE IS A POTENT INHIBITOROF HUMAN DIHYDROOROTATE DEHYDROGENASE, Biochemistry, 35(4), 1996, pp. 1270-1273
IMMUNOSUPPRESSIVE STRUCTURE-ACTIVITY-RELATIONSHIPS OF BREQUINAR AND RELATED CINCHONINIC ACID-DERIVATIVES
Authors: BATT DG COPELAND RA DOWLING RL GARDNER TL JONES EA ORWAT MJ PINTO DJ PITTS WJ MAGOLDA RL JAFFEE BD
Citation: Dg. Batt et al., IMMUNOSUPPRESSIVE STRUCTURE-ACTIVITY-RELATIONSHIPS OF BREQUINAR AND RELATED CINCHONINIC ACID-DERIVATIVES, Bioorganic & medicinal chemistry letters, 5(14), 1995, pp. 1549-1554
SUBSTRATE-BASED INHIBITORS OF LANOSTEROL 14-ALPHA-METHYL DEMETHYLASE .1. ASSESSMENT OF INHIBITOR STRUCTURE-ACTIVITY RELATIONSHIP AND CHOLESTEROL-BIOSYNTHESIS INHIBITION PROPERTIES
Authors: TRZASKOS JM KO SS MAGOLDA RL FAVATA MF FISCHER RT STAM SH JOHNSON PR GAYLOR JL
Citation: Jm. Trzaskos et al., SUBSTRATE-BASED INHIBITORS OF LANOSTEROL 14-ALPHA-METHYL DEMETHYLASE .1. ASSESSMENT OF INHIBITOR STRUCTURE-ACTIVITY RELATIONSHIP AND CHOLESTEROL-BIOSYNTHESIS INHIBITION PROPERTIES, Biochemistry, 34(30), 1995, pp. 9670-9676
SUBSTRATE-BASED INHIBITORS OF LANOSTEROL 14-ALPHA-METHYL DEMETHYLASE .2. TIME-DEPENDENT ENZYME INACTIVATION BY SELECTED OXYLANOSTEROL ANALOGS
Authors: TRZASKOS JM FISCHER RT KO SS MAGOLDA RL STAM S JOHNSON O GAYLOR JL
Citation: Jm. Trzaskos et al., SUBSTRATE-BASED INHIBITORS OF LANOSTEROL 14-ALPHA-METHYL DEMETHYLASE .2. TIME-DEPENDENT ENZYME INACTIVATION BY SELECTED OXYLANOSTEROL ANALOGS, Biochemistry, 34(30), 1995, pp. 9677-9681
INHIBITION OF CARTILAGE DEGRADATION BY ISOTHIAZOLOQUINOLINONES
Authors: MILLER WH PINTO DJP MCHUGH RJ ARNER EC PRATTA MA MAGOLDA RL
Citation: Wh. Miller et al., INHIBITION OF CARTILAGE DEGRADATION BY ISOTHIAZOLOQUINOLINONES, Bioorganic & medicinal chemistry letters, 4(6), 1994, pp. 843-846
HETEROARYL-FUSED 2-PHENYLISOTHIAZOLONE INHIBITORS OF CARTILAGE BREAKDOWN
Authors: WRIGHT SW PETRAITIS JJ ABELMAN MM BATT DG BOSTROM LL CORBETT RL DECICCO CP DIMEO SV FREIMARK B GIANNARAS JV GREEN AM JETTER JW NELSON DJ ORWAT MJ PINTO DJ PRATTA MA SHERK SR WILLIAMS JM MAGOLDA RL ARNER EC
Citation: Sw. Wright et al., HETEROARYL-FUSED 2-PHENYLISOTHIAZOLONE INHIBITORS OF CARTILAGE BREAKDOWN, Journal of medicinal chemistry, 37(19), 1994, pp. 3071-3078
INHIBITION OF CARTILAGE BREAKDOWN BY ISOTHIAZOLONES
Authors: WRIGHT SW PETRAITIS JJ ABELMAN MM BOSTROM LL CORBETT RL GREEN AM KINDT RM SHERK SR MAGOLDA RL
Citation: Sw. Wright et al., INHIBITION OF CARTILAGE BREAKDOWN BY ISOTHIAZOLONES, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2875-2878
MODULATION OF 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE BY 15-ALPHA-FLUOROLANOST-7-EN-3-BETA-OL - A MECHANISM-BASED INHIBITOR OF CHOLESTEROL-BIOSYNTHESIS
Authors: TRZASKOS JM MAGOLDA RL FAVATA MF FISCHER RT JOHNSON PR CHEN HW KO SS LEONARD DA GAYLOR JL
Citation: Jm. Trzaskos et al., MODULATION OF 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE BY 15-ALPHA-FLUOROLANOST-7-EN-3-BETA-OL - A MECHANISM-BASED INHIBITOR OF CHOLESTEROL-BIOSYNTHESIS, The Journal of biological chemistry, 268(30), 1993, pp. 22591-22599
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