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Results: 1-17 |
Results: 17
Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain
Authors: Smith, TS Southan, C Ellington, K Campbell, D Tew, DG Debouck, C
Citation: Ts. Smith et al., Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain, GENOMICS, 78(1-2), 2001, pp. 12-14
Steady-state kinetic characterization of substrates and metal-ion specificities of the full-length and N-terminally truncated recombinant human methionine aminopeptidases (type 2)
Authors: Yang, G Kirkpatrick, RB Ho, T Zhang, GF Liang, PH Johanson, KO Casper, DJ Doyle, ML Marino, JP Thompson, SK Chen, WF Tew, DG Meek, TD
Citation: G. Yang et al., Steady-state kinetic characterization of substrates and metal-ion specificities of the full-length and N-terminally truncated recombinant human methionine aminopeptidases (type 2), BIOCHEM, 40(35), 2001, pp. 10645-10654
ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site
Authors: Hussain, I Powell, DJ Howlett, DR Chapman, GA Gilmour, L Murdock, PR Tew, DG Meek, TD Chapman, C Schneider, K Ratcliffe, SJ Tattersall, D Testa, TT Southan, C Ryan, DM Simmons, DL Walsh, FS Dingwall, C Christie, G
Citation: I. Hussain et al., ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site, MOL CELL NE, 16(5), 2000, pp. 609-619
2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A(2)
Authors: Boyd, HF Flynn, ST Hickey, DMB Ife, RJ Jones, M Leach, CA Macphee, CH Milliner, KJ Rawlings, DA Slingsby, BP Smith, SA Stansfield, IG Tew, DG Theobald, CJ
Citation: Hf. Boyd et al., 2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A(2), BIOORG MED, 10(4), 2000, pp. 395-398
N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A(2)
Authors: Boyd, HF Fell, SCM Flynn, ST Hickey, DMB Ife, RJ Leach, CA Macphee, CH Milliner, KJ Moores, KE Pinto, IL Porter, RA Rawlings, DA Smith, SA Stansfield, IG Tew, DG Theobald, CJ Whittaker, CM
Citation: Hf. Boyd et al., N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A(2), BIOORG MED, 10(22), 2000, pp. 2557-2561
Cloning and characterization of a novel human dual flavin reductase
Authors: Paine, MJI Garner, AP Powell, D Sibbald, J Sales, M Pratt, N Smith, T Tew, DG Wolf, CR
Citation: Mji. Paine et al., Cloning and characterization of a novel human dual flavin reductase, J BIOL CHEM, 275(2), 2000, pp. 1471-1478
Solid-phase synthesis of a combinatorial array of 1,3-bis(acylamino)-2-butanones, inhibitors of the cysteine proteases cathepsins K and L
Authors: Yamashita, DS Dong, XY Oh, HJ Brook, CS Tomaszek, TA Szewczuk, L Tew, DG Veber, DF
Citation: Ds. Yamashita et al., Solid-phase synthesis of a combinatorial array of 1,3-bis(acylamino)-2-butanones, inhibitors of the cysteine proteases cathepsins K and L, J COMB CHEM, 1(3), 1999, pp. 207-215
Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase, is expressed by macrophages in human and rabbit atherosclerotic lesions
Authors: Hakkinen, T Luoma, JS Hiltunen, MO Macphee, CH Milliner, KJ Patel, L Rice, SQ Tew, DG Karkola, K Yla-Herttuala, S
Citation: T. Hakkinen et al., Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase, is expressed by macrophages in human and rabbit atherosclerotic lesions, ART THROM V, 19(12), 1999, pp. 2909-2917
Identification of a novel aspartic protease (Asp 2) as beta-secretase
Authors: Hussain, I Powell, D Howlett, DR Tew, DG Week, TD Chapman, C Gloger, IS Murphy, KE Southan, CD Ryan, DM Smith, TS Simmons, DL Walsh, FS Dingwall, C Christie, G
Citation: I. Hussain et al., Identification of a novel aspartic protease (Asp 2) as beta-secretase, MOL CELL NE, 14(6), 1999, pp. 419-427
Structure-based design of non-peptide, carbohydrazide-based cathepsin K inhibitors
Authors: Thompson, SK Halbert, SM DesJarlais, RL Tomaszek, TA Levy, MA Tew, DG Ijames, CF Veber, DF
Citation: Sk. Thompson et al., Structure-based design of non-peptide, carbohydrazide-based cathepsin K inhibitors, BIO MED CH, 7(4), 1999, pp. 599-605
Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones
Authors: Jarvest, RL Pinto, IL Ashman, SM Dabrowski, CE Fernandez, AV Jennings, LJ Lavery, P Tew, DG
Citation: Rl. Jarvest et al., Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones, BIOORG MED, 9(3), 1999, pp. 443-448
Inhibition of human cytomegalovirus protease by enedione derivatives of thieno[2,3-d]oxazinones through a novel dual acylation/alkylation mechanism
Authors: Pinto, IL Jarvest, RL Clarke, B Dabrowski, CE Fenwick, A Gorczyca, MM Jennings, LJ Lavery, P Sternberg, EJ Tew, DG West, A
Citation: Il. Pinto et al., Inhibition of human cytomegalovirus protease by enedione derivatives of thieno[2,3-d]oxazinones through a novel dual acylation/alkylation mechanism, BIOORG MED, 9(3), 1999, pp. 449-452
Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor
Authors: Macphee, CH Moores, KE Boyd, HF Dhanak, D Ife, RJ Leach, CA Leake, DS Milliner, KJ Patterson, RA Suckling, KE Tew, DG Hickey, DMB
Citation: Ch. Macphee et al., Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor, BIOCHEM J, 338, 1999, pp. 479-487
Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents
Authors: Garner, AP Paine, MJI Rodriguez-Crespo, I Chinje, EC De Montellano, PO Stratford, IJ Tew, DG Wolf, CR
Citation: Ap. Garner et al., Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents, CANCER RES, 59(8), 1999, pp. 1929-1934
Mechanism of inhibition of cathepsin K by potent, selective 1,5-diacylcarbohydrazides: A new class of mechanism-based inhibitors of thiol proteases
Authors: Bossard, MJ Tomaszek, TA Levy, MA Ijames, CF Huddleston, MJ Briand, J Thompson, S Halpert, S Veber, DF Carr, SA Meek, TD Tew, DG
Citation: Mj. Bossard et al., Mechanism of inhibition of cathepsin K by potent, selective 1,5-diacylcarbohydrazides: A new class of mechanism-based inhibitors of thiol proteases, BIOCHEM, 38(48), 1999, pp. 15893-15902
Benzothiopyran-4-one based reversible inhibitors of the human cytomegalovirus (HCMV) protease
Authors: Dhanak, D Keenan, RM Burton, G Kaura, A Darcy, MG Shah, DH Ridgers, LH Breen, A Lavery, P Tew, DG West, A
Citation: D. Dhanak et al., Benzothiopyran-4-one based reversible inhibitors of the human cytomegalovirus (HCMV) protease, BIOORG MED, 8(24), 1998, pp. 3677-3682
Napsins: new human aspartic proteinases - Distinction between two closely related genes
Authors: Tatnell, PJ Powell, DJ Hill, J Smith, TS Tew, DG Kay, J
Citation: Pj. Tatnell et al., Napsins: new human aspartic proteinases - Distinction between two closely related genes, FEBS LETTER, 441(1), 1998, pp. 43-48
Risultati: 1-17 |