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Results: 1-11 |
Results: 11
Synthesis of the first example of a C2-C3/C2 '-C3 '-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer
Authors: Gregson, SJ Howard, PW Corcoran, KE Jenkins, TC Kelland, LR Thurston, DE
Citation: Sj. Gregson et al., Synthesis of the first example of a C2-C3/C2 '-C3 '-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer, BIOORG MED, 11(21), 2001, pp. 2859-2862
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity
Authors: Gregson, SJ Howard, PW Hartley, JA Brooks, NA Adams, LJ Jenkins, TC Kelland, LR Thurston, DE
Citation: Sj. Gregson et al., Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity, J MED CHEM, 44(5), 2001, pp. 737-748
Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT
Authors: Sagnou, MJ Howard, PW Gregson, SJ Eno-Amooquaye, E Burke, PJ Thurston, DE
Citation: Mj. Sagnou et al., Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT, BIOORG MED, 10(18), 2000, pp. 2083-2086
Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines
Authors: Gregson, SJ Howard, PW Corcoran, KE Barcella, S Yasin, MM Hurst, AA Jenkins, TC Kelland, LR Thurston, DE
Citation: Sj. Gregson et al., Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines, BIOORG MED, 10(16), 2000, pp. 1845-1847
Effect of C2/C3-endo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines
Authors: Gregson, SJ Howard, PW Barcella, S Nakamya, A Jenkins, TC Kelland, LR Thurston, DE
Citation: Sj. Gregson et al., Effect of C2/C3-endo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines, BIOORG MED, 10(16), 2000, pp. 1849-1851
Solid-phase synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines
Authors: Berry, JM Howard, PW Thurston, DE
Citation: Jm. Berry et al., Solid-phase synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines, TETRAHEDR L, 41(32), 2000, pp. 6171-6174
Synthesis of a novel C2/C2 '-exo unsaturated pyrrolobenzodiazepine cross-linking agent with remarkable DNA binding affinity and cytotoxicity
Authors: Gregson, SJ Howard, PW Jenkins, TC Kelland, LR Thurston, DE
Citation: Sj. Gregson et al., Synthesis of a novel C2/C2 '-exo unsaturated pyrrolobenzodiazepine cross-linking agent with remarkable DNA binding affinity and cytotoxicity, CHEM COMMUN, (9), 1999, pp. 797-798
Synthesis, in vitro antiproliferative activity, and DNA-binding propertiesof hybrid molecules containing pyrrolo[2,1-c][1,4]benzodiazepine and minor-groove-binding oligopyrrole carriers
Authors: Baraldi, PG Balboni, G Cacciari, B Guiotto, A Manfredini, S Romagnoli, R Spalluto, G Thurston, DE Howard, PW Bianchi, N Rutigliano, C Mischiati, C Gambari, R
Citation: Pg. Baraldi et al., Synthesis, in vitro antiproliferative activity, and DNA-binding propertiesof hybrid molecules containing pyrrolo[2,1-c][1,4]benzodiazepine and minor-groove-binding oligopyrrole carriers, J MED CHEM, 42(25), 1999, pp. 5131-5141
Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2,1-c][1,4]benzodiazepine system
Authors: Wilson, SC Howard, PW Forrow, SM Hartley, JA Adams, LJ Jenkins, TC Kelland, LR Thurston, DE
Citation: Sc. Wilson et al., Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2,1-c][1,4]benzodiazepine system, J MED CHEM, 42(20), 1999, pp. 4028-4041
Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c] [1,4]benzodiazepines
Authors: Thurston, DE Bose, DS Howard, PW Jenkins, TC Leoni, A Baraldi, PG Guiotto, A Cacciari, B Kelland, LR Foloppe, MP Rault, S
Citation: De. Thurston et al., Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c] [1,4]benzodiazepines, J MED CHEM, 42(11), 1999, pp. 1951-1964
Nucleic acid targeting: therapeutic strategies for the 21st century
Authors: Thurston, DE
Citation: De. Thurston, Nucleic acid targeting: therapeutic strategies for the 21st century, BR J CANC, 80, 1999, pp. 65-85
Risultati: 1-11 |