Authors:
Gregson, SJ
Howard, PW
Corcoran, KE
Jenkins, TC
Kelland, LR
Thurston, DE
Citation: Sj. Gregson et al., Synthesis of the first example of a C2-C3/C2 '-C3 '-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer, BIOORG MED, 11(21), 2001, pp. 2859-2862
Authors:
Gregson, SJ
Howard, PW
Hartley, JA
Brooks, NA
Adams, LJ
Jenkins, TC
Kelland, LR
Thurston, DE
Citation: Sj. Gregson et al., Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity, J MED CHEM, 44(5), 2001, pp. 737-748
Authors:
Sagnou, MJ
Howard, PW
Gregson, SJ
Eno-Amooquaye, E
Burke, PJ
Thurston, DE
Citation: Mj. Sagnou et al., Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT, BIOORG MED, 10(18), 2000, pp. 2083-2086
Authors:
Gregson, SJ
Howard, PW
Corcoran, KE
Barcella, S
Yasin, MM
Hurst, AA
Jenkins, TC
Kelland, LR
Thurston, DE
Citation: Sj. Gregson et al., Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines, BIOORG MED, 10(16), 2000, pp. 1845-1847
Authors:
Gregson, SJ
Howard, PW
Barcella, S
Nakamya, A
Jenkins, TC
Kelland, LR
Thurston, DE
Citation: Sj. Gregson et al., Effect of C2/C3-endo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines, BIOORG MED, 10(16), 2000, pp. 1849-1851
Authors:
Gregson, SJ
Howard, PW
Jenkins, TC
Kelland, LR
Thurston, DE
Citation: Sj. Gregson et al., Synthesis of a novel C2/C2 '-exo unsaturated pyrrolobenzodiazepine cross-linking agent with remarkable DNA binding affinity and cytotoxicity, CHEM COMMUN, (9), 1999, pp. 797-798
Authors:
Baraldi, PG
Balboni, G
Cacciari, B
Guiotto, A
Manfredini, S
Romagnoli, R
Spalluto, G
Thurston, DE
Howard, PW
Bianchi, N
Rutigliano, C
Mischiati, C
Gambari, R
Citation: Pg. Baraldi et al., Synthesis, in vitro antiproliferative activity, and DNA-binding propertiesof hybrid molecules containing pyrrolo[2,1-c][1,4]benzodiazepine and minor-groove-binding oligopyrrole carriers, J MED CHEM, 42(25), 1999, pp. 5131-5141
Authors:
Wilson, SC
Howard, PW
Forrow, SM
Hartley, JA
Adams, LJ
Jenkins, TC
Kelland, LR
Thurston, DE
Citation: Sc. Wilson et al., Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2,1-c][1,4]benzodiazepine system, J MED CHEM, 42(20), 1999, pp. 4028-4041
Authors:
Thurston, DE
Bose, DS
Howard, PW
Jenkins, TC
Leoni, A
Baraldi, PG
Guiotto, A
Cacciari, B
Kelland, LR
Foloppe, MP
Rault, S
Citation: De. Thurston et al., Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c] [1,4]benzodiazepines, J MED CHEM, 42(11), 1999, pp. 1951-1964