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Results: 1-16 |
Results: 16
Quantitative determination of L-775,606, a selective 5-hydroxytryptamine 1D agonist, in rat plasma using automated sample preparation and detection by liquid chromatography-tandem mass spectrometry
Authors: Locker, KL Morrison, D Watt, AP
Citation: Kl. Locker et al., Quantitative determination of L-775,606, a selective 5-hydroxytryptamine 1D agonist, in rat plasma using automated sample preparation and detection by liquid chromatography-tandem mass spectrometry, J CHROMAT B, 750(1), 2001, pp. 13-23
Determination of the collisionally activated dissociation of a substitutedindole by orthogonal acceleration quadrupole time-of-flight mass spectrometry
Authors: Watt, AP Pike, A Morrison, D
Citation: Ap. Watt et al., Determination of the collisionally activated dissociation of a substitutedindole by orthogonal acceleration quadrupole time-of-flight mass spectrometry, J AM SOC M, 12(11), 2001, pp. 1145-1152
2-aryl indole NK1 receptor antagonists: Optimisation of indole substitution
Authors: Cooper, LC Chicchi, GG Dinnell, K Elliott, JM Hollingworth, GJ Kurtz, MM Locker, KL Morrison, D Shaw, DE Tsao, KL Watt, AP Williams, AR Swain, CJ
Citation: Lc. Cooper et al., 2-aryl indole NK1 receptor antagonists: Optimisation of indole substitution, BIOORG MED, 11(9), 2001, pp. 1233-1236
2-aryl indole NK1 antagonists: Optimisation of the amide substituent
Authors: Shaw, D Chicchi, GG Elliott, JM Kurtz, M Morrison, D Ridgill, MP Szeto, N Watt, AP Williams, AR Swain, CJ
Citation: D. Shaw et al., 2-aryl indole NK1 antagonists: Optimisation of the amide substituent, BIOORG MED, 11(23), 2001, pp. 3031-3034
Use of chiral liquid chromatography-tandem mass spectrometry to investigate the metabolism of racemic cholecystokinin-B antagonists
Authors: Watt, AP Hitzel, L Morrison, D Locker, KL
Citation: Ap. Watt et al., Use of chiral liquid chromatography-tandem mass spectrometry to investigate the metabolism of racemic cholecystokinin-B antagonists, J CHROMAT A, 896(1-2), 2000, pp. 217-227
Determination of the in vitro metabolism of (+)- and (-)-epibatidine
Authors: Watt, AP Hitzel, L Morrison, D Locker, KL
Citation: Ap. Watt et al., Determination of the in vitro metabolism of (+)- and (-)-epibatidine, J CHROMAT A, 896(1-2), 2000, pp. 229-238
Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery
Authors: Watt, AP Morrison, D Evans, DC
Citation: Ap. Watt et al., Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery, DRUG DISC T, 5(1), 2000, pp. 17-24
Chiral separation of 4,4-disubstituted piperidinyl substance P antagonists
Authors: Watt, AP Hitzel, L
Citation: Ap. Watt et L. Hitzel, Chiral separation of 4,4-disubstituted piperidinyl substance P antagonists, J LIQ CHR R, 23(16), 2000, pp. 2541-2552
An increased throughput method for the determination of partition coefficients
Authors: Hitzel, L Watt, AP Locker, KL
Citation: L. Hitzel et al., An increased throughput method for the determination of partition coefficients, PHARM RES, 17(11), 2000, pp. 1389-1395
Higher throughput bioanalysis by automation of a protein precipitation assay using a 96-well format with detection by LC-MS/MS
Authors: Watt, AP Morrison, D Locker, KL Evans, DC
Citation: Ap. Watt et al., Higher throughput bioanalysis by automation of a protein precipitation assay using a 96-well format with detection by LC-MS/MS, ANALYT CHEM, 72(5), 2000, pp. 979-984
Enantiomeric separation of a series of 1,4-benzodiazepin-2-one CCKB receptor antagonists bearing acidic substituents by chiral HPLC
Authors: Watt, AP Rathbone, D Verrier, HM Chambers, MS Hobbs, SC
Citation: Ap. Watt et al., Enantiomeric separation of a series of 1,4-benzodiazepin-2-one CCKB receptor antagonists bearing acidic substituents by chiral HPLC, J LIQ CHR R, 22(3), 1999, pp. 333-344
Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT1A and 5-HT re-uptake ligands
Authors: van Niel, MB Beer, MS Castro, JL Cheng, SKF Evans, DC Heald, A Hitzel, L Hunt, P Mortishire-Smith, R O'Connor, D Watt, AP MacLeod, AM
Citation: Mb. Van Niel et al., Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT1A and 5-HT re-uptake ligands, BIOORG MED, 9(22), 1999, pp. 3243-3248
Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: Potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor
Authors: Sternfeld, F Guiblin, AR Jelley, RA Matassa, VG Reeve, AJ Hunt, PA Beer, MS Heald, A Stanton, JA Sohal, B Watt, AP Street, LJ
Citation: F. Sternfeld et al., Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: Potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor, J MED CHEM, 42(4), 1999, pp. 677-690
3-(piperazinylpropyl)indoles: Selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents
Authors: Chambers, MS Street, LJ Goodacre, S Hobbs, SC Hunt, P Jelley, RA Matassa, VG Reeve, AJ Sternfeld, F Beer, MS Stanton, JA Rathbone, D Watt, AP MacLeod, AM
Citation: Ms. Chambers et al., 3-(piperazinylpropyl)indoles: Selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents, J MED CHEM, 42(4), 1999, pp. 691-705
3-[3-(Piperidin-1-yl)propyl] indoles as highly selective h5-HT1D receptor agonists
Authors: Russell, MGN Matassa, VG Pengilley, RR van Niel, MB Sohal, B Watt, AP Hitzel, L Beer, MS Stanton, JA Broughton, HB Castro, JL
Citation: Mgn. Russell et al., 3-[3-(Piperidin-1-yl)propyl] indoles as highly selective h5-HT1D receptor agonists, J MED CHEM, 42(24), 1999, pp. 4981-5001
Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles
Authors: van Niel, MB Collins, I Beer, MS Broughton, HB Cheng, SKF Goodacre, SC Heald, A Locker, KL MacLeod, AM Morrison, D Moyes, CR O'Connor, D Pike, A Rowley, M Russell, MGN Moyes, CR O'Connor, D Pike, A Rowley, M Russell, MGN Sohal, B Stanton, JA Thomas, S Verrier, H Watt, AP Castro, JL
Citation: Mb. Van Niel et al., Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles, J MED CHEM, 42(12), 1999, pp. 2087-2104
Risultati: 1-16 |