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NUCLEOTIDE DELIVERY FROM CYCLOSALIGENYL-3'-AZIDO-3'-DEOXYTHYMIDINE MONOPHOSPHATES (CYCLOSAL-AZTMP)
Authors: MEIER C DECLERCQ E BALZARINI J
Citation: C. Meier et al., NUCLEOTIDE DELIVERY FROM CYCLOSALIGENYL-3'-AZIDO-3'-DEOXYTHYMIDINE MONOPHOSPHATES (CYCLOSAL-AZTMP), EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (5), 1998, pp. 837-846
NEW ANTIVIRALS - MECHANISM OF ACTION AND RESISTANCE DEVELOPMENT
Authors: BALZARINI J NAESENS L DECLERCQ E
Citation: J. Balzarini et al., NEW ANTIVIRALS - MECHANISM OF ACTION AND RESISTANCE DEVELOPMENT, Current opinion in microbiology, 1(5), 1998, pp. 535-546
IMPROVING AZT EFFICACY
Authors: BALZARINI J DEGREVE B DECLERCQ E
Citation: J. Balzarini et al., IMPROVING AZT EFFICACY, Nature medicine, 4(2), 1998, pp. 132-132
MARKED INHIBITORY ACTIVITY OF MASKED ARYLOXY AMINOACYL PHOSPHORAMIDATE DERIVATIVES OF DIDEOXYNUCLEOSIDE ANALOGS AGAINST VISNA VIRUS-INFECTION
Authors: BALZARINI J CAHARD D WEDGWOOD O SALGADO A VELAZQUEZ T YARNOLD CJ DECLERCQ E MCGUIGAN C THORMAR H
Citation: J. Balzarini et al., MARKED INHIBITORY ACTIVITY OF MASKED ARYLOXY AMINOACYL PHOSPHORAMIDATE DERIVATIVES OF DIDEOXYNUCLEOSIDE ANALOGS AGAINST VISNA VIRUS-INFECTION, Journal of acquired immune deficiency syndromes and human retrovirology, 17(4), 1998, pp. 296-302
EFFICACY OF THE ACYCLIC NUCLEOSIDE PHOSPHONATES (S)-9-(3-FLUORO-2-PHOSPHONYLMETHOXYPROPYL)ADENINE (FPMPA) AND 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE (PMEA) AGAINST FELINE IMMUNODEFICIENCY VIRUS
Authors: HARTMANN K KUFFER M BALZARINI J NAESENS L GOLDBERG M ERFLE V GOEBEL FD DECLERCQ E JINDRICH J HOLY A BISCHOFBERGER N KRAFT W
Citation: K. Hartmann et al., EFFICACY OF THE ACYCLIC NUCLEOSIDE PHOSPHONATES (S)-9-(3-FLUORO-2-PHOSPHONYLMETHOXYPROPYL)ADENINE (FPMPA) AND 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE (PMEA) AGAINST FELINE IMMUNODEFICIENCY VIRUS, Journal of acquired immune deficiency syndromes and human retrovirology, 17(2), 1998, pp. 120-128
RETINOIDS AS POTENTIAL CHEMOTHERAPEUTIC-AGENTS - SYNTHESIS, CYTOSTATIC AND DIFFERENTIATING ACTIVITIES OF NEW HETEROCYCLIC-ANALOGS OF RETINOIC ACID
Authors: MANFREDINI S SIMONI D CAMINITI G VERTUANI S INVIDIATA F MOSCATO B HATSE S DECLERCQ E BALZARINI J
Citation: S. Manfredini et al., RETINOIDS AS POTENTIAL CHEMOTHERAPEUTIC-AGENTS - SYNTHESIS, CYTOSTATIC AND DIFFERENTIATING ACTIVITIES OF NEW HETEROCYCLIC-ANALOGS OF RETINOIC ACID, Medicinal chemistry research, 8(6), 1998, pp. 291-304
SUPERIOR CYTOSTATIC ACTIVITY OF THE GANCICLOVIR ELAIDIC ACID ESTER DUE TO THE PROLONGED INTRACELLULAR RETENTION OF GANCICLOVIR ANABOLITES IN HERPES-SIMPLEX VIRUS TYPE-1 THYMIDINE KINASE GENE-TRANSFECTED TUMOR-CELLS
Authors: BALZARINI J DEGREVE B ANDREI G NEYTS J SANDVOLD M MYHREN F DECLERCQ E
Citation: J. Balzarini et al., SUPERIOR CYTOSTATIC ACTIVITY OF THE GANCICLOVIR ELAIDIC ACID ESTER DUE TO THE PROLONGED INTRACELLULAR RETENTION OF GANCICLOVIR ANABOLITES IN HERPES-SIMPLEX VIRUS TYPE-1 THYMIDINE KINASE GENE-TRANSFECTED TUMOR-CELLS, Gene therapy, 5(3), 1998, pp. 419-426
LACTATE CANNOT SUBSTITUTE FOR ALANINE IN D4T-BASED ANTI-HIV NUCLEOTIDE PRODRUGS - DESPITE EFFICIENT ESTERASE-MEDIATED HYDROLYSIS
Authors: MCGUIGAN C CAHARD D BALLATORE C SIDDIQUI A DECLERCQ E BALZARINI J
Citation: C. Mcguigan et al., LACTATE CANNOT SUBSTITUTE FOR ALANINE IN D4T-BASED ANTI-HIV NUCLEOTIDE PRODRUGS - DESPITE EFFICIENT ESTERASE-MEDIATED HYDROLYSIS, Bioorganic & medicinal chemistry letters, 8(21), 1998, pp. 2949-2954
SYNTHESIS AND BIOLOGICAL EVALUATION OF 1,2-DISUBSTITUTED CARBONUCLEOSIDES OF 2-AMINO-6-SUBSTITUTED PURINE AND 8-AZAPURINE
Authors: SANTANA L TEIJEIRA M URIARTE E BALZARINI J DECLERCQ E
Citation: L. Santana et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF 1,2-DISUBSTITUTED CARBONUCLEOSIDES OF 2-AMINO-6-SUBSTITUTED PURINE AND 8-AZAPURINE, Bioorganic & medicinal chemistry letters, 8(11), 1998, pp. 1349-1352
DESIGN AND SYNTHESIS OF BIO-ISOSTERES OF THYMIDINE TRIPHOSPHATE
Authors: GOLDRING AO BALZARINI J GILBERT IH
Citation: Ao. Goldring et al., DESIGN AND SYNTHESIS OF BIO-ISOSTERES OF THYMIDINE TRIPHOSPHATE, Bioorganic & medicinal chemistry letters, 8(10), 1998, pp. 1211-1214
BROAD-SPECTRUM ANTIVIRAL ACTIVITY AND MECHANISM OF ANTIVIRAL ACTION OF THE FLUOROQUINOLONE DERIVATIVE K-12
Authors: WITVROUW M DAELEMANS D PANNECOUQUE C NEYTS J ANDREI G SNOECK R VANDAMME AM BALZARINI J DESMYTER J BABA M DECLERCQ E
Citation: M. Witvrouw et al., BROAD-SPECTRUM ANTIVIRAL ACTIVITY AND MECHANISM OF ANTIVIRAL ACTION OF THE FLUOROQUINOLONE DERIVATIVE K-12, Antiviral chemistry & chemotherapy, 9(5), 1998, pp. 403-411
AN APPROACH TOWARDS THE SYNTHESIS OF POTENTIAL METAL-CHELATING TSAO-TDERIVATIVES AS BIDENTATE INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE
Authors: CHAMORRO C CAMARASA MJ PEREZPEREZ MJ DECLERCQ E BALZARINI J SANFELIX A
Citation: C. Chamorro et al., AN APPROACH TOWARDS THE SYNTHESIS OF POTENTIAL METAL-CHELATING TSAO-TDERIVATIVES AS BIDENTATE INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE, Antiviral chemistry & chemotherapy, 9(5), 1998, pp. 413-422
NOVEL 3'-SPIRO NUCLEOSIDE ANALOGS OF TSAO-T - PART II - A COMPARATIVE-STUDY BASED ON NMR CONFORMATIONAL-ANALYSIS IN SOLUTION AND THEORETICAL CALCULATIONS
Authors: ALVAREZ R JIMENO ML GAGO F BALZARINI J PEREZPEREZ MJ CAMARASA MJ
Citation: R. Alvarez et al., NOVEL 3'-SPIRO NUCLEOSIDE ANALOGS OF TSAO-T - PART II - A COMPARATIVE-STUDY BASED ON NMR CONFORMATIONAL-ANALYSIS IN SOLUTION AND THEORETICAL CALCULATIONS, Antiviral chemistry & chemotherapy, 9(4), 1998, pp. 333-340
TREATMENT OF VISNA VIRUS-INFECTION IN LAMBS WITH THE ACYCLIC NUCLEOSIDE PHOSPHONATE ANALOG 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE (PMEA)
Authors: THORMAR H GEORGSSON G GUNNARSSON E NAESENS L TORSTEINSDOTTIR S BALZARINI J DECLERCQ E
Citation: H. Thormar et al., TREATMENT OF VISNA VIRUS-INFECTION IN LAMBS WITH THE ACYCLIC NUCLEOSIDE PHOSPHONATE ANALOG 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE (PMEA), Antiviral chemistry & chemotherapy, 9(3), 1998, pp. 245-252
SYNTHESIS AND ANTI-HIV ACTIVITY OF SOME NOVEL CHAIN-EXTENDED PHOSPHORAMIDATE DERIVATIVES OF D4T (STAVUDINE) - ESTERASE HYDROLYSIS AS A RAPID PREDICTIVE TEST FOR ANTIVIRAL POTENCY
Authors: MCGUIGAN C TSANG HW SUTTON PW DECLERCQ E BALZARINI J
Citation: C. Mcguigan et al., SYNTHESIS AND ANTI-HIV ACTIVITY OF SOME NOVEL CHAIN-EXTENDED PHOSPHORAMIDATE DERIVATIVES OF D4T (STAVUDINE) - ESTERASE HYDROLYSIS AS A RAPID PREDICTIVE TEST FOR ANTIVIRAL POTENCY, Antiviral chemistry & chemotherapy, 9(2), 1998, pp. 109-115
SYNTHESIS AND ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ACTIVITY OF NOVEL 3'-SPIRO NUCLEOSIDE ANALOGS OF TSAO-T (VOL 8, PG 507, 1997)
Authors: ALVAREZ R JIMENO ML PEREZPEREZ MJ DECLERCQ E BALZARINI J CAMARASA MJ
Citation: R. Alvarez et al., SYNTHESIS AND ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ACTIVITY OF NOVEL 3'-SPIRO NUCLEOSIDE ANALOGS OF TSAO-T (VOL 8, PG 507, 1997), Antiviral chemistry & chemotherapy, 9(2), 1998, pp. 185-185
SYNTHESIS OF PHOSPHONATE ANALOGS OF 2-DEOXYRIBOSE-1-PHOSPHATE
Authors: RUBIRA MJ PEREZPEREZ MJ BALZARINI J CAMARASA MJ
Citation: Mj. Rubira et al., SYNTHESIS OF PHOSPHONATE ANALOGS OF 2-DEOXYRIBOSE-1-PHOSPHATE, Synlett, (2), 1998, pp. 177
A NOVEL MUTATION (F227L) ARISES IN THE REVERSE-TRANSCRIPTASE OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ON DOSE-ESCALATING TREATMENT OF HIV TYPE 1-INFECTED CELL-CULTURES WITH THE NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITOR THIOCARBOXANILIDE UC-781
Authors: BALZARINI J PELEMANS H ESNOUF R DECLERCQ E
Citation: J. Balzarini et al., A NOVEL MUTATION (F227L) ARISES IN THE REVERSE-TRANSCRIPTASE OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ON DOSE-ESCALATING TREATMENT OF HIV TYPE 1-INFECTED CELL-CULTURES WITH THE NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITOR THIOCARBOXANILIDE UC-781, AIDS research and human retroviruses, 14(3), 1998, pp. 255-260
NOVEL CARBOCYCLIC NUCLEOSIDES CONTAINING A CYCLOBUTYL RING - GUANOSINE AND ADENOSINE-ANALOGS
Authors: BORGES JER FERNANDEZ F GARCIA X HERGUETA AR LOPEZ C ANDREI G SNOECK R WITVROUNW M BALZARINI J DECLERCQ E
Citation: Jer. Borges et al., NOVEL CARBOCYCLIC NUCLEOSIDES CONTAINING A CYCLOBUTYL RING - GUANOSINE AND ADENOSINE-ANALOGS, Nucleosides & nucleotides, 17(7), 1998, pp. 1237-1253
SYNTHESIS, ANTIVIRAL AND CYTOSTATIC ACTIVITIES OF CARBOCYCLIC NUCLEOSIDES INCORPORATING A MODIFIED CYCLOPENTANE RING - PART 2 - ADENOSINE AND URIDINE ANALOGS
Authors: NIETO MI BLANCO JM CAAMANO O FERNANDEZ F GARCIAMERA X BALZARINI J PADALKO E NEYTS J DECLERCQ E
Citation: Mi. Nieto et al., SYNTHESIS, ANTIVIRAL AND CYTOSTATIC ACTIVITIES OF CARBOCYCLIC NUCLEOSIDES INCORPORATING A MODIFIED CYCLOPENTANE RING - PART 2 - ADENOSINE AND URIDINE ANALOGS, Nucleosides & nucleotides, 17(7), 1998, pp. 1255-1266
SYNTHESIS AND ANTI-HIV PROPERTIES OF 1,2,4,6-THIATRIAZIN-3-ONE 1,1-DIOXIDE NUCLEOSIDES
Authors: OCHOA C PROVENCIO R JIMENO ML BALZARINI J DECLERCQ E
Citation: C. Ochoa et al., SYNTHESIS AND ANTI-HIV PROPERTIES OF 1,2,4,6-THIATRIAZIN-3-ONE 1,1-DIOXIDE NUCLEOSIDES, Nucleosides & nucleotides, 17(5), 1998, pp. 901-910
STABILITY OF UC-781, IN INTESTINAL MUCOSAL HOMOGENATES OF THE RAT, RABBIT, AND PIG
Authors: VANDENMOOTER G STAS G DAMIAN F NAESENS L BALZARINI J KINGET R AUGUSTIJNS P
Citation: G. Vandenmooter et al., STABILITY OF UC-781, IN INTESTINAL MUCOSAL HOMOGENATES OF THE RAT, RABBIT, AND PIG, Pharmaceutical research, 15(11), 1998, pp. 1799-1802
PRECLINICAL STUDIES ON THIOCARBOXANILIDE UC-781 AS A VIRUCIDAL AGENT
Authors: BALZARINI J NAESENS L VERBEKEN E LAGA M VANDAMME L PARNIAK M VANMELLAERT L ANNE J DECLERCQ E
Citation: J. Balzarini et al., PRECLINICAL STUDIES ON THIOCARBOXANILIDE UC-781 AS A VIRUCIDAL AGENT, AIDS, 12(10), 1998, pp. 1129-1138
SELECTION AND CHARACTERIZATION OF MURINE LEUKEMIA-L1210 CELLS WITH HIGH-LEVEL RESISTANCE TO THE CYTOSTATIC ACTIVITY OF THE ACYCLIC NUCLEOSIDE PHOSPHONATE 9-(2-PHOSPHONYLMETHOXYETHYL) ADENINE (PMEA)
Authors: BALZARINI J HATSE S NAESENS L DECLERCQ E
Citation: J. Balzarini et al., SELECTION AND CHARACTERIZATION OF MURINE LEUKEMIA-L1210 CELLS WITH HIGH-LEVEL RESISTANCE TO THE CYTOSTATIC ACTIVITY OF THE ACYCLIC NUCLEOSIDE PHOSPHONATE 9-(2-PHOSPHONYLMETHOXYETHYL) ADENINE (PMEA), Biochimica et biophysica acta. Molecular cell research, 1402(1), 1998, pp. 29-38
1,1,3-TRIOXO-2H,4H-THIENO[3,4-E][1,2,4]THIADIAZINE (TTD) DERIVATIVES - A NEW CLASS OF NONNUCLEOSIDE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) REVERSE-TRANSCRIPTASE INHIBITORS WITH ANTI-HIV-1 ACTIVITY
Authors: WITVROUW M ARRANZ ME PANNECOUQUE C DECLERCQ R JONCKHEERE H SCHMIT JC VANDAMME AM DIAZ JA INGATE ST DESMYTER J ESNOUF R VANMEERVELT L VEGA S BALZARINI J DECLERCQ E
Citation: M. Witvrouw et al., 1,1,3-TRIOXO-2H,4H-THIENO[3,4-E][1,2,4]THIADIAZINE (TTD) DERIVATIVES - A NEW CLASS OF NONNUCLEOSIDE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) REVERSE-TRANSCRIPTASE INHIBITORS WITH ANTI-HIV-1 ACTIVITY, Antimicrobial agents and chemotherapy, 42(3), 1998, pp. 618-623
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