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Results: 1-25 | 26-32
Results: 1-25/32
SERINE DERIVED NK1 ANTAGONISTS 1 - THE EFFECT OF MODIFICATIONS TO THESERINE SUBSTITUENTS
Authors: ELLIOTT JM CASCIERI MA CHICCHI G DAVIES S KELLEHER FJ KURTZ M LADDUWAHETTY T LEWIS RT MACLEOD AM MERCHANT KJ SADOWSKI S STEVENSON GI
Citation: Jm. Elliott et al., SERINE DERIVED NK1 ANTAGONISTS 1 - THE EFFECT OF MODIFICATIONS TO THESERINE SUBSTITUENTS, Bioorganic & medicinal chemistry letters, 8(14), 1998, pp. 1845-1850
SERINE DERIVED NK1 ANTAGONISTS 2 - A PHARMACOPHORE MODEL FOR ARYLSULFONAMIDE BINDING
Authors: ELLIOTT JM BROUGHTON H CASCIERI MA CHICCHI G HUSCROFT IT KURTZ M MACLEOD AM SADOWSKI S STEVENSON GI
Citation: Jm. Elliott et al., SERINE DERIVED NK1 ANTAGONISTS 2 - A PHARMACOPHORE MODEL FOR ARYLSULFONAMIDE BINDING, Bioorganic & medicinal chemistry letters, 8(14), 1998, pp. 1851-1856
HIGH-AFFINITY, SELECTIVE NEUROKININ-2 AND NEUROKININ-3 RECEPTOR ANTAGONISTS FROM A COMMON STRUCTURAL TEMPLATE
Authors: HARRISON T KORSGAARD MPG SWAIN CJ CASCIERI MA SADOWSKI S SEABROOK GR
Citation: T. Harrison et al., HIGH-AFFINITY, SELECTIVE NEUROKININ-2 AND NEUROKININ-3 RECEPTOR ANTAGONISTS FROM A COMMON STRUCTURAL TEMPLATE, Bioorganic & medicinal chemistry letters, 8(11), 1998, pp. 1343-1348
HIGH-AFFINITY PHENYLGLYCINOL-BASED NK1 RECEPTOR ANTAGONISTS
Authors: OWENS AP HARRISON T MOSELEY JD SWAIN CJ SADOWSKI S CASCIERI MA
Citation: Ap. Owens et al., HIGH-AFFINITY PHENYLGLYCINOL-BASED NK1 RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 8(1), 1998, pp. 51-56
DISTINCT MECHANISM FOR ANTIDEPRESSANT ACTIVITY BY BLOCKADE OF CENTRALSUBSTANCE-P RECEPTORS
Authors: KRAMER MS CUTLER N FEIGHNER J SHRIVASTAVA R CARMAN J SRAMEK JJ REINES SA LIU GH SNAVELY D WYATTKNOWLES E HALE JJ MILLS SG MACCOSS M SWAIN CJ HARRISON T HILL RG HEFTI F SCOLNICK EM CASCIERI MA CHICCHI GG SADOWSKI S WILLIAMS AR HEWSON L SMITH D CARLSON EJ HARGREAVES RJ RUPNIAK NMJ
Citation: Ms. Kramer et al., DISTINCT MECHANISM FOR ANTIDEPRESSANT ACTIVITY BY BLOCKADE OF CENTRALSUBSTANCE-P RECEPTORS, Science, 281(5383), 1998, pp. 1640-1645
STRUCTURAL OPTIMIZATION AFFORDING ENYL-4-(3-OXO-1,2,4-TRIAZOL-5-YL)METHYLMORPHOLINE, A POTENT, ORALLY-ACTIVE, LONG-ACTING MORPHOLINE ACETALHUMAN NK-1 RECEPTOR ANTAGONIST
Authors: HALE JJ MILLS SG MACCOSS M FINKE PE CASCIERI MA SADOWSKI S BER E CHICCHI GG KURTZ M METZGER J EIERMANN G TSOU NN TATTERSALL FD RUPNIAK NMJ WILLIAMS AR RYCROFT W HARGREAVES R MACINTYRE DE
Citation: Jj. Hale et al., STRUCTURAL OPTIMIZATION AFFORDING ENYL-4-(3-OXO-1,2,4-TRIAZOL-5-YL)METHYLMORPHOLINE, A POTENT, ORALLY-ACTIVE, LONG-ACTING MORPHOLINE ACETALHUMAN NK-1 RECEPTOR ANTAGONIST, Journal of medicinal chemistry, 41(23), 1998, pp. 4607-4614
4,4-DISUBSTITUTED PIPERIDINE HIGH-AFFINITY NK1 ANTAGONISTS - STRUCTURE-ACTIVITY-RELATIONSHIPS AND IN-VIVO ACTIVITY
Authors: STEVENSON GI HUSCROFT I MACLEOD AM SWAIN CJ CASCIERI MA CHICCHI GG GRAHAM MI HARRISON T KELLEHER FJ KURTZ M LADDUWAHETTY T MERCHANT KJ METZGER JM MACINTYRE DE SADOWSKI S SOHAL B OWENS AP
Citation: Gi. Stevenson et al., 4,4-DISUBSTITUTED PIPERIDINE HIGH-AFFINITY NK1 ANTAGONISTS - STRUCTURE-ACTIVITY-RELATIONSHIPS AND IN-VIVO ACTIVITY, Journal of medicinal chemistry, 41(23), 1998, pp. 4623-4635
3-BENZYLOXY-2-PHENYLPIPERIDINE NK1 ANTAGONISTS - THE INFLUENCE OF ALPHA-METHYL SUBSTITUTION
Authors: SWAIN CJ WILLIAMS BJ BAKER R CASCIERI MA CHICCHI G FORREST M HERBERT R KEOWN L LADDUWAHETTY T LUELL S MACINTYRE DE METZGER J MORTON S OWENS AP SADOWSKI S WATT AP
Citation: Cj. Swain et al., 3-BENZYLOXY-2-PHENYLPIPERIDINE NK1 ANTAGONISTS - THE INFLUENCE OF ALPHA-METHYL SUBSTITUTION, Bioorganic & medicinal chemistry letters, 7(23), 1997, pp. 2959-2962
IN-VITRO AND IN-VIVO PREDICTORS OF THE ANTIEMETIC ACTIVITY OF TACHYKININ NK1 RECEPTOR ANTAGONISTS
Authors: RUPNIAK NMJ TATTERSALL FD WILLIAMS AR RYCROFT W CARLSON EJ CASCIERI MA SADOWSKI S BER E HALE JJ MILLS SG MACCOSS M SEWARD E HUSCROFT I OWEN S SWAIN CJ HILL RG HARGREAVES RJ
Citation: Nmj. Rupniak et al., IN-VITRO AND IN-VIVO PREDICTORS OF THE ANTIEMETIC ACTIVITY OF TACHYKININ NK1 RECEPTOR ANTAGONISTS, European journal of pharmacology, 326(2-3), 1997, pp. 201-209
CHARACTERIZATION OF THE BINDING AND ACTIVITY OF A HIGH-AFFINITY, PSEUDOIRREVERSIBLE MORPHOLINO TACHYKININ NK1 RECEPTOR ANTAGONIST
Authors: CASCIERI MA BER E FONG TM HALE JJ TANG F SHIAO LL MILLS SG MACCOSS M SADOWSKI S TOTA MR STRADER CD
Citation: Ma. Cascieri et al., CHARACTERIZATION OF THE BINDING AND ACTIVITY OF A HIGH-AFFINITY, PSEUDOIRREVERSIBLE MORPHOLINO TACHYKININ NK1 RECEPTOR ANTAGONIST, European journal of pharmacology, 325(2-3), 1997, pp. 253-261
LINEAR AMIDES AS SUBSTANCE-P ANTAGONISTS
Authors: TEALL M HARRISON T MOSELEY JD OWENS AP SADOWSKI S CASCIERI MA
Citation: M. Teall et al., LINEAR AMIDES AS SUBSTANCE-P ANTAGONISTS, Bioorganic & medicinal chemistry letters, 6(13), 1996, pp. 1585-1588
NYL-4-((3-OXO-1,2,4-TRIAZOL-5-YL)METHYL)MORPHOLINE .1. A POTENT, ORALLY-ACTIVE, MORPHOLINE-BASED HUMAN NEUROKININ-1 RECEPTOR ANTAGONIST
Authors: HALE JJ MILLS SG MACCOSS M SHAH SK QI HB MATHRE DJ CASCIERI MA SADOWSKI S STRADER CD MACINTYRE DE METZGER JM
Citation: Jj. Hale et al., NYL-4-((3-OXO-1,2,4-TRIAZOL-5-YL)METHYL)MORPHOLINE .1. A POTENT, ORALLY-ACTIVE, MORPHOLINE-BASED HUMAN NEUROKININ-1 RECEPTOR ANTAGONIST, Journal of medicinal chemistry, 39(9), 1996, pp. 1760-1762
N-HETEROARYL-2-PHENYL-3-(BENZYLOXY)PIPERIDINES - A NOVEL CLASS OF POTENT ORALLY-ACTIVE HUMAN NK1 ANTAGONISTS
Authors: LADDUWAHETTY T BAKER R CASCIERI MA CHAMBERS MS HAWORTH K KEOWN LE MACINTYRE DE METZGER JM OWEN S RYCROFT W SADOWSKI S SEWARD EM SHEPHEARD SL SWAIN CJ TATTERSALL FD WATT AP WILLIAMSON DW HARGREAVES RJ
Citation: T. Ladduwahetty et al., N-HETEROARYL-2-PHENYL-3-(BENZYLOXY)PIPERIDINES - A NOVEL CLASS OF POTENT ORALLY-ACTIVE HUMAN NK1 ANTAGONISTS, Journal of medicinal chemistry, 39(15), 1996, pp. 2907-2914
1,2,4-TRIACYLPIPERIDINE SUBSTANCE-P ANTAGONISTS - SEPARATION OF AFFINITIES FOR THE NK-1 RECEPTOR AND THE L-TYPE CALCIUM-CHANNEL
Authors: MILLS SG MACCOSS M CASCIERI MA SADOWSKI S PATEL S CHAPMAN KL HUTSON PH
Citation: Sg. Mills et al., 1,2,4-TRIACYLPIPERIDINE SUBSTANCE-P ANTAGONISTS - SEPARATION OF AFFINITIES FOR THE NK-1 RECEPTOR AND THE L-TYPE CALCIUM-CHANNEL, Bioorganic & medicinal chemistry letters, 5(6), 1995, pp. 599-604
PIPERIDINE-ETHER BASED HNK(1) ANTAGONISTS .2. INVESTIGATION OF THE EFFECT OF N-SUBSTITUTION
Authors: HARRISON T OWENS AP WILLIAMS BJ SWAIN CJ BAKER R HUTSON PH SADOWSKI S CASCIERI MA
Citation: T. Harrison et al., PIPERIDINE-ETHER BASED HNK(1) ANTAGONISTS .2. INVESTIGATION OF THE EFFECT OF N-SUBSTITUTION, Bioorganic & medicinal chemistry letters, 5(3), 1995, pp. 209-212
PHENYL-GLYCINOL BASED NK1 RECEPTOR ANTAGONISTS - TOWARDS THE MINIMUM PHARMACOPHORE
Authors: OWENS AP WILLIAMS BJ HARRISON T SWAIN CJ BAKER R SADOWSKI S CASCIERI MA
Citation: Ap. Owens et al., PHENYL-GLYCINOL BASED NK1 RECEPTOR ANTAGONISTS - TOWARDS THE MINIMUM PHARMACOPHORE, Bioorganic & medicinal chemistry letters, 5(22), 1995, pp. 2761-2766
1,2,3-TRISUBSTITUTED CYCLOHEXYL SUBSTANCE-P ANTAGONISTS - SIGNIFICANCE OF THE RING NITROGEN IN PIPERIDINE-BASED NK-1 RECEPTOR ANTAGONISTS
Authors: MILLS SG MACCOSS M UNDERWOOD D SHAH SK FINKE PE MILLER DJ BUDHU RJ CASCIERI MA SADOWSKI S STRADER CD
Citation: Sg. Mills et al., 1,2,3-TRISUBSTITUTED CYCLOHEXYL SUBSTANCE-P ANTAGONISTS - SIGNIFICANCE OF THE RING NITROGEN IN PIPERIDINE-BASED NK-1 RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 5(13), 1995, pp. 1345-1350
CHARACTERIZATION OF THE INTERACTION OF DIACYLPIPERAZINE ANTAGONISTS WITH THE HUMAN NEUROKININ-1 RECEPTOR - IDENTIFICATION OF A COMMON BINDING-SITE FOR STRUCTURALLY DISSIMILAR ANTAGONISTS
Authors: CASCIERI MA SHIAO LL MILLS SG MACCOSS M SWAIN CJ YU H BER E SADOWSKI S WU MT STRADER CD FONG TM
Citation: Ma. Cascieri et al., CHARACTERIZATION OF THE INTERACTION OF DIACYLPIPERAZINE ANTAGONISTS WITH THE HUMAN NEUROKININ-1 RECEPTOR - IDENTIFICATION OF A COMMON BINDING-SITE FOR STRUCTURALLY DISSIMILAR ANTAGONISTS, Molecular pharmacology, 47(4), 1995, pp. 660-665
4,4-DISUBSTITUTED PIPERIDINES - A NEW CLASS OF NK1 ANTAGONIST
Authors: STEVENSON GI MACLEOD AM HUSCROFT I CASCIERI MA SADOWSKI S BAKER R
Citation: Gi. Stevenson et al., 4,4-DISUBSTITUTED PIPERIDINES - A NEW CLASS OF NK1 ANTAGONIST, Journal of medicinal chemistry, 38(8), 1995, pp. 1264-1266
TRYPTOPHAN-DERIVED NK1 ANTAGONISTS - CONFORMATIONALLY CONSTRAINED HETEROCYCLIC BIOISOSTERES OF THE ESTER LINKAGE
Authors: LEWIS RT MACLEOD AM MERCHANT KJ KELLEHER F SANDERSON I HERBERT RH CASCIERI MA SADOWSKI S BALL RG HOOGSTEEN K
Citation: Rt. Lewis et al., TRYPTOPHAN-DERIVED NK1 ANTAGONISTS - CONFORMATIONALLY CONSTRAINED HETEROCYCLIC BIOISOSTERES OF THE ESTER LINKAGE, Journal of medicinal chemistry, 38(6), 1995, pp. 923-933
SYNTHESIS AND BIOLOGICAL EVALUATION OF NK1 ANTAGONISTS DERIVED FROM L-TRYPTOPHAN
Authors: MACLEOD AM CASCIERI MA MERCHANT KJ SADOWSKI S HARDWICKE S LEWIS RT MACINTYRE DE METZGER JM FONG TM SHEPHEARD S TATTERSALL FD HARGREAVES R BAKER R
Citation: Am. Macleod et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF NK1 ANTAGONISTS DERIVED FROM L-TRYPTOPHAN, Journal of medicinal chemistry, 38(6), 1995, pp. 934-941
IDENTIFICATION OF A SERIES OF 3-(BENZYLOXY)-1-AZABICYCLO[2.2.2]OCTANEHUMAN NK1 ANTAGONISTS
Authors: SWAIN CJ SEWARD EM CASCIERI MA FONG TM HERBERT R MACINTYRE DE MERCHANT KJ OWEN SN OWENS AP SABIN V TEALL M VANNIEL MB WILLIAMS BJ SADOWSKI S STRADER C BALL RG BAKER R
Citation: Cj. Swain et al., IDENTIFICATION OF A SERIES OF 3-(BENZYLOXY)-1-AZABICYCLO[2.2.2]OCTANEHUMAN NK1 ANTAGONISTS, Journal of medicinal chemistry, 38(24), 1995, pp. 4793-4805
ACYCLIC NK1 ANTAGONISTS - REPLACEMENTS FOR THE BENZHYDRYL GROUP
Authors: SWAIN CJ CASCIERI MA OWENS A SAARI W SADOWSKI S STRADER C TEALL M VANNIEL MB WILLIAMS BJ
Citation: Cj. Swain et al., ACYCLIC NK1 ANTAGONISTS - REPLACEMENTS FOR THE BENZHYDRYL GROUP, Bioorganic & medicinal chemistry letters, 4(18), 1994, pp. 2161-2164
ACYCLIC NK-1 ANTAGONISTS - 2-BENZHYDRYL-2-AMINOETHYL ETHERS
Authors: WILLIAMS BJ TEALL M MCKENNA J HARRISON T SWAIN CJ CASCIERI MA SADOWSKI S STRADER C BAKER R
Citation: Bj. Williams et al., ACYCLIC NK-1 ANTAGONISTS - 2-BENZHYDRYL-2-AMINOETHYL ETHERS, Bioorganic & medicinal chemistry letters, 4(16), 1994, pp. 1903-1908
MORPHOLINE-BASED SUBSTANCE-P ANTAGONISTS - ASSESSMENT OF THE 3-POINT BINDING MODEL
Authors: LADDUWAHETTY T KEOWN L CASCIERI MA SADOWSKI S
Citation: T. Ladduwahetty et al., MORPHOLINE-BASED SUBSTANCE-P ANTAGONISTS - ASSESSMENT OF THE 3-POINT BINDING MODEL, Bioorganic & medicinal chemistry letters, 4(16), 1994, pp. 1917-1920
Risultati: 1-25 | 26-32