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Results: 1-20 |
Results: 20
Design, synthesis, and SAR of amino acid derivatives as factor Xa inhibitors
Authors: Su, T Wu, YH Doughan, B Jia, ZJ Woolfrey, J Huang, B Wong, P Park, G Sinha, U Scarborough, RM Zhu, BY
Citation: T. Su et al., Design, synthesis, and SAR of amino acid derivatives as factor Xa inhibitors, BIOORG MED, 11(22), 2001, pp. 2947-2950
Design and synthesis of glycolic and mandelic acid derivatives as factor Xa inhibitors
Authors: Su, T Wu, YH Doughan, B Kane-Maguire, K Marlowe, CK Kanter, JP Woolfrey, J Huang, B Wong, P Sinha, U Park, G Malinowski, J Hollenbach, S Scarborough, RM Zhu, BY
Citation: T. Su et al., Design and synthesis of glycolic and mandelic acid derivatives as factor Xa inhibitors, BIOORG MED, 11(17), 2001, pp. 2279-2282
Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y(12))
Authors: Scarborough, RM Laibelman, AM Clizbe, LA Fretto, LJ Conley, PB Reynolds, EE Sedlock, DM Jantzen, HM
Citation: Rm. Scarborough et al., Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y(12)), BIOORG MED, 11(14), 2001, pp. 1805-1808
Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: Design of potent and specific 3,9-diazaspiro[5.5]undecanes
Authors: Smyth, MS Rose, J Mehrotra, MM Heath, J Ruhter, G Schotten, T Seroogy, J Volkots, D Pandey, A Scarborough, RM
Citation: Ms. Smyth et al., Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: Design of potent and specific 3,9-diazaspiro[5.5]undecanes, BIOORG MED, 11(10), 2001, pp. 1289-1292
Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 2: Design of potent antagonists containing the 3-azaspiro[5.5]undec-9-yl template
Authors: Pandey, A Seroogy, J Volkots, D Smyth, MS Rose, J Mehrotra, MM Heath, J Ruhter, G Schotten, T Scarborough, RM
Citation: A. Pandey et al., Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 2: Design of potent antagonists containing the 3-azaspiro[5.5]undec-9-yl template, BIOORG MED, 11(10), 2001, pp. 1293-1296
Discovery and optimization of a novel series of thrombin receptor (PAR-1) antagonists: Potent, selective peptide mimetics based on indole and indazole templates
Authors: Zhang, HC Derian, CK Andrade-Gordon, P Hoekstra, WJ McComsey, DF White, KB Poulter, BL Addo, MF Cheung, WM Damiano, BP Oksenberg, D Reynolds, EE Pandey, A Scarborough, RM Maryanoff, BE
Citation: Hc. Zhang et al., Discovery and optimization of a novel series of thrombin receptor (PAR-1) antagonists: Potent, selective peptide mimetics based on indole and indazole templates, J MED CHEM, 44(7), 2001, pp. 1021-1024
Fused bicyclic Gly-Asp beta-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere
Authors: Fisher, MJ Giese, U Harms, CS Kinnick, MD Lindstrom, TD McCowan, JR Mest, HJ Morin, JM Mullaney, JT Paal, M Rapp, A Ruhter, G Ruterbories, KJ Sall, DJ Scarborough, RM Schotten, T Stenzel, W Towner, RD Um, SL Utterback, BG Wyss, VL Jakubowski, JA
Citation: Mj. Fisher et al., Fused bicyclic Gly-Asp beta-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere, BIOORG MED, 10(4), 2000, pp. 385-389
Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: Structures based on the (D)-Arg-Gly-Arg tripeptide sequence
Authors: Marlowe, CK Sinha, U Gunn, AC Scarborough, RM
Citation: Ck. Marlowe et al., Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: Structures based on the (D)-Arg-Gly-Arg tripeptide sequence, BIOORG MED, 10(1), 2000, pp. 13-16
Factor Xa inhibitors: Recent advances in anticoagulant agents
Authors: Zhu, BY Scarborough, RM
Citation: By. Zhu et Rm. Scarborough, Factor Xa inhibitors: Recent advances in anticoagulant agents, ANNU REP M, 35, 2000, pp. 83-102
Extracellular mutations of protease-activated receptor-1 result in differential activation by thrombin and thrombin receptor agonist peptide
Authors: Blackhart, BD Ruslim-Litrus, L Lu, CC Alves, VL Teng, W Scarborough, RM Reynolds, EE Oksenberg, D
Citation: Bd. Blackhart et al., Extracellular mutations of protease-activated receptor-1 result in differential activation by thrombin and thrombin receptor agonist peptide, MOLEC PHARM, 58(6), 2000, pp. 1178-1187
Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: Novel parenteral and potential oral antithrombotic agents
Authors: Scarborough, RM Gretler, DD
Citation: Rm. Scarborough et Dd. Gretler, Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: Novel parenteral and potential oral antithrombotic agents, J MED CHEM, 43(19), 2000, pp. 3453-3473
Antithrombotic and hemostatic capacity of factor Xa versus thrombin inhibitors in models of venous and arteriovenous thrombosis
Authors: Sinha, U Ku, P Malinowski, J Zhu, BY Scarborough, RM Marlowe, CK Wong, PW Lin, PH Hollenbach, SJ
Citation: U. Sinha et al., Antithrombotic and hemostatic capacity of factor Xa versus thrombin inhibitors in models of venous and arteriovenous thrombosis, EUR J PHARM, 395(1), 2000, pp. 51-59
Thrombin receptor-activating peptides (TRAPs): Investigation of bioactive conformations via structure-activity, spectroscopic, and computational studies
Authors: Ceruso, MA McComsey, DF Leo, GC Andrade-Gordon, P Addo, MF Scarborough, RM Oksenberg, D Maryanoff, BE
Citation: Ma. Ceruso et al., Thrombin receptor-activating peptides (TRAPs): Investigation of bioactive conformations via structure-activity, spectroscopic, and computational studies, BIO MED CH, 7(11), 1999, pp. 2353-2371
Structure-activity relationships of beta-amino acid-containing integrin antagonists
Authors: Scarborough, RM
Citation: Rm. Scarborough, Structure-activity relationships of beta-amino acid-containing integrin antagonists, CURR MED CH, 6(10), 1999, pp. 971-981
A new "traceless" solid-phase synthesis strategy: Synthesis of a benzimidazole library
Authors: Huang, WL Scarborough, RM
Citation: Wl. Huang et Rm. Scarborough, A new "traceless" solid-phase synthesis strategy: Synthesis of a benzimidazole library, TETRAHEDR L, 40(14), 1999, pp. 2665-2668
Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor
Authors: Andrade-Gordon, P Mayanoff, BE Derian, CK Zhang, HC Addo, MF Darrow, AL Eckardt, AJ Hoekstra, WJ McComsey, DF Oksenberg, D Reynolds, EE Santulli, RJ Scarborough, RM Smith, CE White, KB
Citation: P. Andrade-gordon et al., Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor, P NAS US, 96(22), 1999, pp. 12257-12262
Fused bicyclic Gly-Asp beta-turn mimics with specific affinity for GPIIb-IIIa
Authors: Fisher, MJ Arfstan, AE Giese, U Gunn, BP Harms, CS Khau, V Kinnick, MD Lindstrom, TD Martinelli, MJ Mest, HJ Mohr, M Morin, JM Mullaney, JT Nunes, A Paal, M Rapp, A Ruhter, G Ruterbories, KJ Sall, DJ Scarborough, RM Schotten, T Sommer, B Stenzel, W Towner, RD Um, SL Utterback, BG Vasileff, RT Voelkers, S Wyss, VL Jakubowski, JA
Citation: Mj. Fisher et al., Fused bicyclic Gly-Asp beta-turn mimics with specific affinity for GPIIb-IIIa, J MED CHEM, 42(23), 1999, pp. 4875-4889
Platelet glycoprotein IIb/IIIa antagonists - What are the relevant issues concerning their pharmacology and clinical use?
Authors: Scarborough, RM Kleiman, NS Phillips, DR
Citation: Rm. Scarborough et al., Platelet glycoprotein IIb/IIIa antagonists - What are the relevant issues concerning their pharmacology and clinical use?, CIRCULATION, 100(4), 1999, pp. 437-444
Development of eptifibatide
Authors: Scarborough, RM
Citation: Rm. Scarborough, Development of eptifibatide, AM HEART J, 138(6), 1999, pp. 1093-1104
Coagulation factor Xa: The prothrombinase complex as an emerging therapeutic target for small molecule inhibitors
Authors: Scarborough, RM
Citation: Rm. Scarborough, Coagulation factor Xa: The prothrombinase complex as an emerging therapeutic target for small molecule inhibitors, J ENZ INHIB, 14(1), 1998, pp. 15-25
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