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Results: 1-25 | 26-37
Results: 1-25/37
Synthesis of nodulisporic acid 2 ''-oxazoles and 2 ''-thiazoles
Authors: Berger, R Shoop, WL Pivnichny, JV Warmke, LM Zakson-Aiken, M Owens, KA deMontigny, P Schmatz, DM Wyvratt, MJ Fisher, MH Meinke, PT Colletti, SL
Citation: R. Berger et al., Synthesis of nodulisporic acid 2 ''-oxazoles and 2 ''-thiazoles, ORG LETT, 3(23), 2001, pp. 3715-3718
2-(3,5-dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor
Authors: Lin, P Marino, D Lo, JL Yang, YT Cheng, K Smith, RG Fisher, MH Wyvratt, MJ Goulet, MT
Citation: P. Lin et al., 2-(3,5-dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor, BIOORG MED, 11(8), 2001, pp. 1073-1076
Heterocyclic derivatives of 2-(3,5-dimethylphenyl)tryptamine as GnRH receptor antagonists
Authors: Lin, P Parikh, M Lo, JL Yang, YT Cheng, K Smith, RG Fisher, MH Wyvratt, MJ Goulet, MT
Citation: P. Lin et al., Heterocyclic derivatives of 2-(3,5-dimethylphenyl)tryptamine as GnRH receptor antagonists, BIOORG MED, 11(8), 2001, pp. 1077-1080
Initial structure-activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindoles
Authors: Chu, L Hutchins, JE Weber, AE Lo, JL Yang, YT Cheng, K Smith, RG Fisher, MH Wyvratt, MJ Goulet, MT
Citation: L. Chu et al., Initial structure-activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindoles, BIOORG MED, 11(4), 2001, pp. 509-513
SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists
Authors: Chu, L Lo, JL Yang, YT Cheng, K Smith, RG Fisher, MH Wyvratt, MJ Goulet, MT
Citation: L. Chu et al., SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists, BIOORG MED, 11(4), 2001, pp. 515-517
Human beta(3) adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties
Authors: Brockunier, LL Candelore, MR Cascieri, MA Liu, Y Tota, L Wyvratt, MJ Fisher, MH Weber, AE Parmee, ER
Citation: Ll. Brockunier et al., Human beta(3) adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties, BIOORG MED, 11(3), 2001, pp. 379-382
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: Structure-activity relationships of apicidin. Part 1
Authors: Colletti, SL Myers, RW Darkin-Rattray, SJ Gurnett, AM Dulski, PM Galuska, S Allocco, JJ Ayer, MB Li, CS Lim, J Crumley, TM Cannova, C Schmatz, DM Wyvratt, MJ Fisher, MH Meinke, PT
Citation: Sl. Colletti et al., Broad spectrum antiprotozoal agents that inhibit histone deacetylase: Structure-activity relationships of apicidin. Part 1, BIOORG MED, 11(2), 2001, pp. 107-111
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: Structure-activity relationships of apicidin. Part 2
Authors: Colletti, SL Myers, RW Darkin-Rattray, SJ Gurnett, AM Dulski, PM Galuska, S Allocco, JJ Ayer, MB Li, CS Lim, J Crumley, TM Cannova, C Schmatz, DM Wyvratt, MJ Fisher, MH Meinke, PT
Citation: Sl. Colletti et al., Broad spectrum antiprotozoal agents that inhibit histone deacetylase: Structure-activity relationships of apicidin. Part 2, BIOORG MED, 11(2), 2001, pp. 113-117
Systemic efficacy of nodulisporamides against fleas on dogs
Authors: Shoop, WL Zakson-Aiken, M Gregory, LM Michael, BF Pivnichny, J Meinke, PT Fisher, MH Wyvratt, MJ Pikounis, B Schmatz, DM
Citation: Wl. Shoop et al., Systemic efficacy of nodulisporamides against fleas on dogs, J PARASITOL, 87(5), 2001, pp. 1150-1154
A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor
Authors: DeVita, RJ Walsh, TF Young, JR Jiang, JL Ujjainwalla, F Toupence, RB Parikh, M Huang, SX Fair, JA Goulet, MT Wyvratt, MJ Lo, JL Ren, N Yudkovitz, JB Yang, YT Cheng, K Cui, JS Mount, G Rohrer, SP Schaeffer, JM Rhodes, L Drisko, JE McGowan, E MacIntyre, DE Vincent, S Carlin, JR Cameron, J Smith, RG
Citation: Rj. Devita et al., A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor, J MED CHEM, 44(6), 2001, pp. 917-922
Next generation therapeutics - Drug discovery in the 21st Century
Authors: Wyvratt, MJ Doherty, A
Citation: Mj. Wyvratt et A. Doherty, Next generation therapeutics - Drug discovery in the 21st Century, CURR OP C B, 4(4), 2000, pp. 369-370
Potent antagonists of gonadotropin releasing hormone receptors derived from quinolone-6-carboxamides
Authors: Walsh, TF Toupence, RB Young, JR Huang, SX Ujjainwalla, F DeVita, RJ Goulet, MT Wyvratt, MJ Fisher, MH Lo, JL Ren, N Yudkovitz, JB Yang, YT Cheng, K Smith, RG
Citation: Tf. Walsh et al., Potent antagonists of gonadotropin releasing hormone receptors derived from quinolone-6-carboxamides, BIOORG MED, 10(5), 2000, pp. 443-447
Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta(3) adrenergic receptor agonists
Authors: Parmee, ER Brockunier, LL He, JF Singh, SB Candelore, MR Cascieri, MA Deng, LP Liu, Y Tota, L Wyvratt, MJ Fisher, MH Weber, AE
Citation: Er. Parmee et al., Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta(3) adrenergic receptor agonists, BIOORG MED, 10(20), 2000, pp. 2283-2286
Chemical modification of nodulisporic acid A: Preliminary structure-activity relationships
Authors: Meinke, PT Ayer, MB Colletti, SL Li, CS Lim, J Ok, D Salva, S Schmatz, DM Shih, TL Shoop, WL Warmke, LM Wyvratt, MJ Zakson-Aiken, M Fisher, MH
Citation: Pt. Meinke et al., Chemical modification of nodulisporic acid A: Preliminary structure-activity relationships, BIOORG MED, 10(20), 2000, pp. 2371-2374
Human beta 3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides
Authors: Brockunier, LL Parmee, ER Ok, HO Candelore, MR Cascieri, MA Colwell, LF Deng, LP Feeney, WP Forrest, MJ Hom, GJ MacIntyre, DE Tota, L Wyvratt, MJ Fisher, MH Weber, AE
Citation: Ll. Brockunier et al., Human beta 3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides, BIOORG MED, 10(18), 2000, pp. 2111-2114
Potent, selective 3-pyridylethanolamine beta(3) adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore
Authors: Mathvink, RJ Tolman, JS Chitty, D Candelore, MR Cascieri, MA Colwell, LF Deng, LP Feeney, WP Forrest, MJ Hom, GJ MacIntyre, DE Tota, L Wyvratt, MJ Fisher, MH Weber, AE
Citation: Rj. Mathvink et al., Potent, selective 3-pyridylethanolamine beta(3) adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore, BIOORG MED, 10(17), 2000, pp. 1971-1973
Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents
Authors: Young, JR Huang, SX Chen, I Walsh, TF DeVita, RJ Wyvratt, MJ Goulet, MT Ren, N Lo, J Yang, YT Yudkovitz, JB Cheng, K Smith, RG
Citation: Jr. Young et al., Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents, BIOORG MED, 10(15), 2000, pp. 1723-1727
Substituted oxazole benzenesulfonamides as potent human beta(3) adrenergicreceptor agonists
Authors: Ok, HO Reigle, LB Candelore, MR Cascieri, MA Colwell, LF Deng, L Feeney, WP Forrest, MJ Hom, GJ MacIntyre, DE Strader, CD Tota, L Wang, P Wyvratt, MJ Fisher, MH Weber, AE
Citation: Ho. Ok et al., Substituted oxazole benzenesulfonamides as potent human beta(3) adrenergicreceptor agonists, BIOORG MED, 10(14), 2000, pp. 1531-1534
Discovery of an orally bioavailable alkyl oxadiazole beta(3) adrenergic receptor agonist
Authors: Feng, DQD Biftu, T Candelore, MR Cascieri, MA Colwell, LF Deng, LP Feeney, WP Forrest, MJ Hom, GJ MacIntyre, DE Miller, RR Stearns, RA Strader, CD Tota, L Wyvratt, MJ Fisher, MH Weber, AE
Citation: Dqd. Feng et al., Discovery of an orally bioavailable alkyl oxadiazole beta(3) adrenergic receptor agonist, BIOORG MED, 10(13), 2000, pp. 1427-1429
Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta(3) adrenergic receptor agonist antiobesity agents
Authors: Biftu, T Feng, DD Liang, GB Kuo, H Qian, XX Naylor, EM Colandrea, VJ Candelore, MR Cascieri, MA Colwell, LF Forrest, MJ Hom, GJ MacIntyre, DE Stearns, RA Strader, CD Wyvratt, MJ Fisher, MH Weber, AE
Citation: T. Biftu et al., Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta(3) adrenergic receptor agonist antiobesity agents, BIOORG MED, 10(13), 2000, pp. 1431-1434
Tryptophan-replacement and indole-modifed apicidins: synthesis of potent and selective antiprotozoal agents
Authors: Colletti, SL Li, CS Fisher, MH Wyvratt, MJ Meinke, PT
Citation: Sl. Colletti et al., Tryptophan-replacement and indole-modifed apicidins: synthesis of potent and selective antiprotozoal agents, TETRAHEDR L, 41(41), 2000, pp. 7825-7829
Synthesis of side chain modified apicidin derivatives: potent mechanism-based histone deacetylase inhibitors
Authors: Meinke, PT Colletti, SL Ayer, MB Darkin-Rattray, SJ Myers, RW Schmatz, DM Wyvratt, MJ Fisher, MH
Citation: Pt. Meinke et al., Synthesis of side chain modified apicidin derivatives: potent mechanism-based histone deacetylase inhibitors, TETRAHEDR L, 41(41), 2000, pp. 7831-7835
Design and synthesis of histone deacetylase inhibitors: the development ofapicidin transition state analogs
Authors: Colletti, SL Myers, RW Darkin-Rattray, SJ Schmatz, DM Fisher, MH Wyvratt, MJ Meinke, PT
Citation: Sl. Colletti et al., Design and synthesis of histone deacetylase inhibitors: the development ofapicidin transition state analogs, TETRAHEDR L, 41(41), 2000, pp. 7837-7841
Synthesis of apicidin-derived quinolone derivatives: Parasite-selective histone deacetylase inhibitors and antiproliferative agents
Authors: Meinke, PT Colletti, SL Doss, G Myers, RW Gurnett, AM Dulski, PM Darkin-Rattray, SJ Allocco, JJ Galuska, S Schmatz, DM Wyvratt, MJ Fisher, MH
Citation: Pt. Meinke et al., Synthesis of apicidin-derived quinolone derivatives: Parasite-selective histone deacetylase inhibitors and antiproliferative agents, J MED CHEM, 43(25), 2000, pp. 4919-4922
Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide
Authors: Mathvink, RJ Tolman, JS Chitty, D Candelore, MR Cascieri, MA Colwell, LF Deng, LP Feeney, WP Forrest, MJ Hom, GJ MacIntyre, DE Miller, RR Stearns, RA Tota, L Wyvratt, MJ Fisher, MH Weber, AE
Citation: Rj. Mathvink et al., Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide, J MED CHEM, 43(21), 2000, pp. 3832-3836
Risultati: 1-25 | 26-37