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ANTI-HIV PRONUCLEOTIDES - DECOMPOSITION PATHWAYS AND CORRELATION WITHBIOLOGICAL-ACTIVITIES
Authors: EGRON D LEFEBVRE I PERIGAUD C BELTRAN T POMPON A GOSSELIN G AUBERTIN AM IMBACH JL
Citation: D. Egron et al., ANTI-HIV PRONUCLEOTIDES - DECOMPOSITION PATHWAYS AND CORRELATION WITHBIOLOGICAL-ACTIVITIES, Bioorganic & medicinal chemistry letters, 8(9), 1998, pp. 1045-1050
RATIONAL DESIGN OF A NEW SERIES OF MIXED ANTI-HIV PRONUCLEOTIDES
Authors: SCHLIENGER N BELTRAN T PERIGAUD C LEFEBVRE I POMPON A AUBERTIN AM GOSSELIN G IMBACH JL
Citation: N. Schlienger et al., RATIONAL DESIGN OF A NEW SERIES OF MIXED ANTI-HIV PRONUCLEOTIDES, Bioorganic & medicinal chemistry letters, 8(21), 1998, pp. 3003-3006
FIRST SYNTHESIS OF ALTERNATING SATE-PHOSPHOTRIESTER PHOSPHODIESTER PROOLIGONUCLEOTIDES ON SOLID SUPPORT/
Authors: TOSQUELLAS G BOLOGNA JC MORVAN F RAYNER B IMBACH JL
Citation: G. Tosquellas et al., FIRST SYNTHESIS OF ALTERNATING SATE-PHOSPHOTRIESTER PHOSPHODIESTER PROOLIGONUCLEOTIDES ON SOLID SUPPORT/, Bioorganic & medicinal chemistry letters, 8(20), 1998, pp. 2913-2918
SYNTHESIS AND ANTIVIRAL EVALUATION OF SATE-FOSCARNET PRODRUGS AND NEWFOSCARNET-AZT CONJUGATES
Authors: MEIER C AUBERTIN AM DEMONTE M FARAJ A SOMMADOSSI JP PERIGAUD C IMBACH JL GOSSELIN G
Citation: C. Meier et al., SYNTHESIS AND ANTIVIRAL EVALUATION OF SATE-FOSCARNET PRODRUGS AND NEWFOSCARNET-AZT CONJUGATES, Antiviral chemistry & chemotherapy, 9(1), 1998, pp. 41-52
STABILITY STUDIES IN BIOLOGICAL MEDIA OF DIMER PHOSPHOTRIESTERS BEARING GLUCURONIC-ACID RESIDUE
Authors: MIGNET N CHAIX C IMBACH JL
Citation: N. Mignet et al., STABILITY STUDIES IN BIOLOGICAL MEDIA OF DIMER PHOSPHOTRIESTERS BEARING GLUCURONIC-ACID RESIDUE, Nucleosides & nucleotides, 17(9-11), 1998, pp. 1583-1587
EFFECT OF THE THIOALKYL CHAIN VARIATION IN THE EFFICIENCY OF SATE PRONUCLEOTIDES
Authors: EGRON D PERIGAUD C AUBERTIN AM IMBACH JL GOSSELIN C
Citation: D. Egron et al., EFFECT OF THE THIOALKYL CHAIN VARIATION IN THE EFFICIENCY OF SATE PRONUCLEOTIDES, Nucleosides & nucleotides, 17(9-11), 1998, pp. 1725-1729
UNNATURAL BETA-L-ENANTIOMERS OF NUCLEOSIDE ANALOGS AS POTENT ANTI-HEPATITIS-B VIRUS AGENTS
Authors: GOSSELIN G BOUDOU V GRIFFON JF PAVIA G PIERRA C IMBACH JL FARAJ A SOMMADOSSI JP
Citation: G. Gosselin et al., UNNATURAL BETA-L-ENANTIOMERS OF NUCLEOSIDE ANALOGS AS POTENT ANTI-HEPATITIS-B VIRUS AGENTS, Nucleosides & nucleotides, 17(9-11), 1998, pp. 1731-1738
COMPARATIVE STABILITY OF TRIPLE HELICES CONTAINING MODIFIED DNA OR RNA PYRIMIDINE STRANDS
Authors: MORVAN F IMBACH JL RAYNER B
Citation: F. Morvan et al., COMPARATIVE STABILITY OF TRIPLE HELICES CONTAINING MODIFIED DNA OR RNA PYRIMIDINE STRANDS, Nucleosides & nucleotides, 17(9-11), 1998, pp. 1949-1952
A REINVESTIGATION OF SULFENYL GROUPS AS AMINO PROTECTING GROUPS FOR THE SYNTHESIS OF OLIGONUCLEOTIDES ON SOLID SUPPORT BY PHOSPHORAMIDITE CHEMISTRY
Authors: ALVAREZ K TWORKOWSKI I VASSEUR JJ IMBACH JL RAYNER B
Citation: K. Alvarez et al., A REINVESTIGATION OF SULFENYL GROUPS AS AMINO PROTECTING GROUPS FOR THE SYNTHESIS OF OLIGONUCLEOTIDES ON SOLID SUPPORT BY PHOSPHORAMIDITE CHEMISTRY, Nucleosides & nucleotides, 17(1-3), 1998, pp. 365-378
SYNTHESIS AND ANTIVIRAL EVALUATION OF 2'-DEOXY-4'-THIO-L-NUCLEOSIDES AND THEIR PHOSPHOTRIESTER DERIVATIVES BEARING S-ACYL-2-THIOETHYL BIOREVERSIBLE PHOSPHATE-PROTECTING GROUPS
Authors: DEVALETTE F BARASCUT JL IMBACH JL
Citation: F. Devalette et al., SYNTHESIS AND ANTIVIRAL EVALUATION OF 2'-DEOXY-4'-THIO-L-NUCLEOSIDES AND THEIR PHOSPHOTRIESTER DERIVATIVES BEARING S-ACYL-2-THIOETHYL BIOREVERSIBLE PHOSPHATE-PROTECTING GROUPS, Nucleosides & nucleotides, 17(12), 1998, pp. 2289-2310
COMPARISON OF THE DISPOSITION OF ESTER PRODRUGS OF THE ANTIVIRAL AGENT 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE [PMEA] IN CACO-2 MONOLAYERS
Authors: ANNAERT P GOSSELIN G POMPON A BENZARIA S VALETTE G IMBACH JL NAESENS L HATSE S DECLERCQ E VANDENMOOTER G KINGET R AUGUSTIJNS P
Citation: P. Annaert et al., COMPARISON OF THE DISPOSITION OF ESTER PRODRUGS OF THE ANTIVIRAL AGENT 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE [PMEA] IN CACO-2 MONOLAYERS, Pharmaceutical research, 15(2), 1998, pp. 239-245
THE PRO-OLIGONUCLEOTIDE APPROACH - SOLID-PHASE SYNTHESIS AND PRELIMINARY EVALUATION OF MODEL PRO-DODECATHYMIDYLATES
Authors: TOSQUELLAS G ALVAREZ K DELLAQUILA C MORVAN F VASSEUR JJ IMBACH JL RAYNER B
Citation: G. Tosquellas et al., THE PRO-OLIGONUCLEOTIDE APPROACH - SOLID-PHASE SYNTHESIS AND PRELIMINARY EVALUATION OF MODEL PRO-DODECATHYMIDYLATES, Nucleic acids research, 26(9), 1998, pp. 2069-2074
SYNTHESIS OF (Z)-ALPHA-ALKENYL AND (E)-ALPHA-ALKENYL PHOSPHONIC ACID-DERIVATIVES OF PURINES AND PYRIMIDINES
Authors: LAZREK HB ROCHDI A KHAIDER H BARASCUT JL IMBACH JL BALZARINI J WITVROUW M PANNECOUQUE C DECLERCQ E
Citation: Hb. Lazrek et al., SYNTHESIS OF (Z)-ALPHA-ALKENYL AND (E)-ALPHA-ALKENYL PHOSPHONIC ACID-DERIVATIVES OF PURINES AND PYRIMIDINES, Tetrahedron, 54(15), 1998, pp. 3807-3816
PHOSPHOPEPTIDE PRODRUG BEARING AN S-ACYL-2-THIOETHYL ENZYME-LABILE PHOSPHATE PROTECTION
Authors: MATHE C PERIGAUD C GOSSELIN G IMBACH JL
Citation: C. Mathe et al., PHOSPHOPEPTIDE PRODRUG BEARING AN S-ACYL-2-THIOETHYL ENZYME-LABILE PHOSPHATE PROTECTION, Journal of organic chemistry, 63(23), 1998, pp. 8547-8550
A COMPARISON OF THE ENANTIOSELECTIVITIES OF HUMAN DEOXYCYTIDINE KINASE AND HUMAN CYTIDINE DEAMINASE
Authors: SHAFIEE M GRIFFON JF GOSSELIN G CAMBI A VINCENZETTI S VITA A ERIKSSON S IMBACH JL MAURY G
Citation: M. Shafiee et al., A COMPARISON OF THE ENANTIOSELECTIVITIES OF HUMAN DEOXYCYTIDINE KINASE AND HUMAN CYTIDINE DEAMINASE, Biochemical pharmacology, 56(9), 1998, pp. 1237-1242
THE PROOLIGONUCLEOTIDE APPROACH - SYNTHESIS AND STABILITY OF CHIMERICPROOLIGONUCLEOTIDES IN CULTURE-MEDIUM AND IN TOTAL CELL EXTRACT
Authors: MIGNET N TOSQUELLAS G BARBER I MORVAN F RAYNER B IMBACH JL
Citation: N. Mignet et al., THE PROOLIGONUCLEOTIDE APPROACH - SYNTHESIS AND STABILITY OF CHIMERICPROOLIGONUCLEOTIDES IN CULTURE-MEDIUM AND IN TOTAL CELL EXTRACT, New journal of chemistry, 21(1), 1997, pp. 73-79
COMPARATIVE STABILITY OF 8 DIFFERENT TRIPLE HELICES FORMED BY DIFFERENTLY MODIFIED DNA OR RNA PYRIMIDINE STRANDS AND A DNA HAIRPIN
Authors: MORVAN F IMBACH JL RAYNER B
Citation: F. Morvan et al., COMPARATIVE STABILITY OF 8 DIFFERENT TRIPLE HELICES FORMED BY DIFFERENTLY MODIFIED DNA OR RNA PYRIMIDINE STRANDS AND A DNA HAIRPIN, ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, 7(4), 1997, pp. 327-334
THE PRO-OLIGONUCLEOTIDE APPROACH .5. INFLUENCE OF THE PHOSPHORUS ATOMENVIRONMENT ON THE HYDROLYSIS OF ENZYMOLABILE DINUCLEOSIDE PHOSPHOTRIESTERS
Authors: MIGNET N MORVAN F RAYNER B IMBACH JL
Citation: N. Mignet et al., THE PRO-OLIGONUCLEOTIDE APPROACH .5. INFLUENCE OF THE PHOSPHORUS ATOMENVIRONMENT ON THE HYDROLYSIS OF ENZYMOLABILE DINUCLEOSIDE PHOSPHOTRIESTERS, Bioorganic & medicinal chemistry letters, 7(7), 1997, pp. 851-854
THE PROOLIGONUCLEOTIDE APPROACH .4. SYNTHESIS OF CHIMERIC PROOLIGONUCLEOTIDES WITH 6 ENZYMOLABILE MASKING GROUPS AND UNEXPECTED DESULFURIZATION SIDE REACTION
Authors: TOSQUELLAS G MORVAN F RAYNER B IMBACH JL
Citation: G. Tosquellas et al., THE PROOLIGONUCLEOTIDE APPROACH .4. SYNTHESIS OF CHIMERIC PROOLIGONUCLEOTIDES WITH 6 ENZYMOLABILE MASKING GROUPS AND UNEXPECTED DESULFURIZATION SIDE REACTION, Bioorganic & medicinal chemistry letters, 7(3), 1997, pp. 263-268
HUMAN-IMMUNODEFICIENCY-VIRUS RESISTANCE TO AZT IN MOLT4 8 CELLS IS ASSOCIATED WITH A LACK OF AZT PHOSPHORYLATION AND IS BYPASSED BY AZT-MONOPHOSPHATE SATE PRODRUGS/
Authors: CINATL J GROSCHEL B ZEHNER R CINATL J PERIGAUD C GOSSELIN G IMBACH JL DOERR HW
Citation: J. Cinatl et al., HUMAN-IMMUNODEFICIENCY-VIRUS RESISTANCE TO AZT IN MOLT4 8 CELLS IS ASSOCIATED WITH A LACK OF AZT PHOSPHORYLATION AND IS BYPASSED BY AZT-MONOPHOSPHATE SATE PRODRUGS/, Antiviral chemistry & chemotherapy, 8(4), 1997, pp. 343-352
FAST-ATOM-BOMBARDMENT MASS-SPECTROMETRIC STUDY OF SATE FOSCARNET PRODRUGS AND OF A SERIES OF FOSCARNET-AZT CONJUGATES
Authors: ROZENSKI J MEIER C AUBAGNAC JL ASTIER R HERDEWIJN P IMBACH JL GOSSELIN G
Citation: J. Rozenski et al., FAST-ATOM-BOMBARDMENT MASS-SPECTROMETRIC STUDY OF SATE FOSCARNET PRODRUGS AND OF A SERIES OF FOSCARNET-AZT CONJUGATES, Rapid communications in mass spectrometry, 11(11), 1997, pp. 1212-1218
ONLINE CLEANING HPLC-UV-MS - A TOOL FOR ANALYZING NEW ANTI-HIV DRUGS IN BIOLOGICAL MEDIA
Authors: LEFEBVRE I POMPON A VALETTE G PERIGAUD C GOSSELIN G IMBACH JL
Citation: I. Lefebvre et al., ONLINE CLEANING HPLC-UV-MS - A TOOL FOR ANALYZING NEW ANTI-HIV DRUGS IN BIOLOGICAL MEDIA, LC GC, 15(9), 1997, pp. 868
SYNTHESIS OF 3'-DEOXY-3' AND 5'-DEOXY-5'-[4-(PURIN-9-YL PYRIMIDIN-1-YL)METHYL-1,2,3-TRIAZOL-1-YL]THYMIDINE VIA 1,3-DIPOLAR CYCLOADDITION/
Authors: LAZREK HB TAOURIRTE M OULIH T KABBAJ Y BARASCUT JL IMBACH JL ALMASOUDI NA PFLEIDERER W
Citation: Hb. Lazrek et al., SYNTHESIS OF 3'-DEOXY-3' AND 5'-DEOXY-5'-[4-(PURIN-9-YL PYRIMIDIN-1-YL)METHYL-1,2,3-TRIAZOL-1-YL]THYMIDINE VIA 1,3-DIPOLAR CYCLOADDITION/, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1073-1077
SYNTHESIS OF NEW 1,2,3-TRIAZOLE ACYCLONUCLEOSIDE ANALOGS OF ACV AND HBG
Authors: LAZREK HB TAOURIRTE M OULIH T LEBTOUMI M BARASCUT JL IMBACH JL
Citation: Hb. Lazrek et al., SYNTHESIS OF NEW 1,2,3-TRIAZOLE ACYCLONUCLEOSIDE ANALOGS OF ACV AND HBG, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1115-1118
THE PRO-OLIGONUCLEOTIDE APPROACH - CHIMERIC DODECAMERS BEARING 6 BIOREVERSIBLE PROTECTING GROUPS
Authors: MORVAN F TOSQUELLAS G MIGNET N BARBER I RAYNER B IMBACH JL
Citation: F. Morvan et al., THE PRO-OLIGONUCLEOTIDE APPROACH - CHIMERIC DODECAMERS BEARING 6 BIOREVERSIBLE PROTECTING GROUPS, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1213-1214
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