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Results: 1-25/31
Authors:
Deshmukh, RR
Eriksson, KO
Moore, P
Cole, DL
Sanghvi, YS
Citation: Rr. Deshmukh et al., A case study: Oligonucleotide purification from gram to hundred gram scale, NUCLEOS NUC, 20(4-7), 2001, pp. 567-576
Authors:
Krotz, AH
Gaus, H
Ravikumar, VT
Cole, DL
Citation: Ah. Krotz et al., Preparation of oligonucleotides without aldehyde abasic sites, BIOORG MED, 11(14), 2001, pp. 1863-1867
Authors:
Sanghvi, YS
Ravikumar, VT
Scozzari, AN
Cole, DL
Citation: Ys. Sanghvi et al., Applications of green chemistry in the manufacture of oligonucleotide drugs, PUR A CHEM, 73(1), 2001, pp. 175-180
Authors:
Deshmukh, RR
Warner, TN
Hutchison, F
Murphy, M
Leitch, WE
De Leon, P
Srivatsa, GS
Cole, DL
Sanghvi, YS
Citation: Rr. Deshmukh et al., Large-scale purification of antisense oligonucleotides by high-performancemembrane adsorber chromatography, J CHROMAT A, 890(1), 2000, pp. 179-192
Authors:
Cheruvallath, ZS
Sasmor, H
Cole, DL
Ravikumar, VT
Citation: Zs. Cheruvallath et al., Influence of diastereomeric ratios of deoxyribonucleoside phosphoramiditeson the synthesis of phosphorothioate oligonucleotides, NUCLEOS NUC, 19(3), 2000, pp. 533-543
Authors:
Eleuteri, A
Capaldi, DC
Krotz, AH
Cole, DL
Ravikumar, VT
Citation: A. Eleuteri et al., Pyridinium trifluoroacetate/N-methylimidazole as an efficient activator for oligonucleotide synthesis via the phosphoramidite method, ORG PROC R, 4(3), 2000, pp. 182-189
Authors:
Krotz, AH
Carty, RL
Scozzari, AN
Cole, DL
Ravikumar, VT
Citation: Ah. Krotz et al., Large-scale synthesis of antisense oligonucleotides without chlorinated solvents, ORG PROC R, 4(3), 2000, pp. 190-193
Authors:
Cheruvallath, ZS
Carty, RL
Moore, MN
Capaldi, DC
Krotz, AH
Wheeler, PD
Turney, BJ
Craig, SR
Gaus, HJ
Scozzari, AN
Cole, DL
Ravikumar, VT
Citation: Zs. Cheruvallath et al., Synthesis of antisense oligonucleotides: Replacement of 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage reagent) with phenylacetyl disulfide (PADS) as efficient sulfurization reagent: From bench to bulk manufacture of activepharmaceutical ingredient, ORG PROC R, 4(3), 2000, pp. 199-204
Authors:
Deshmukh, RR
Miller, JE
De Leon, P
Leitch, WE
Cole, DL
Sanghvi, YS
Citation: Rr. Deshmukh et al., Process development for purification of therapeutic antisense oligonucleotides by anion-exchange chromatography, ORG PROC R, 4(3), 2000, pp. 205-213
Authors:
Bonora, GM
Rossin, R
Zaramella, S
Cole, DL
Eleuteri, A
Ravikumar, VT
Citation: Gm. Bonora et al., A liquid-phase process suitable for large-scale synthesis of phosphorothioate oligonucleotides, ORG PROC R, 4(3), 2000, pp. 225-231
Authors:
Chen, DH
Cole, DL
Srivastsa, GS
Citation: Dh. Chen et al., Determination of free and encapsulated oligonucleotides in liposome formulated drug product, J PHARM B, 22(5), 2000, pp. 791-801
Authors:
Cole, DL
Citation: Dl. Cole, Mose Harper: Eccentricity and survival in The 'Searchers', LIT-FILM Q, 28(3), 2000, pp. 222-226
Authors:
Deshmukh, RR
Cole, DL
Sanghvi, YS
Citation: Rr. Deshmukh et al., Purification of antisense oligonucleotides, METH ENZYM, 313, 2000, pp. 203-226
Authors:
Deshmukh, RR
Leitch, WE
Sanghvi, YS
Cole, DL
Citation: Rr. Deshmukh et al., Large-scale chromatographic purification oligonucleotides, SEPAR SCI S, 2, 2000, pp. 511-534
Authors:
Srivatsa, GS
Ravikumar, V
Scozzari, AN
Cole, DL
Citation: Gs. Srivatsa et al., Special issues for synthetic antisense oligonucleotides, BIOTECH & B, 25, 2000, pp. 309-327
Authors:
Krotz, AH
Carty, RL
Moore, MN
Scozzari, AN
Cole, DL
Ravikumar, VT
Citation: Ah. Krotz et al., Synthesis of antisense oligonucleotides using environmentally friendly andsafe deprotection procedures, GREEN CHEM, 1(6), 1999, pp. 277-281
Authors:
Capaldi, DC
Scozzari, AN
Cole, DL
Ravikumar, VT
Citation: Dc. Capaldi et al., Is it essential to use anhydrous acetonitrile in the manufacture of phosphorothioate oligonucleotides?, ORG PROC R, 3(6), 1999, pp. 485-487
Authors:
Krotz, AH
Cole, DL
Ravikumar, VT
Citation: Ah. Krotz et al., Synthesis of an antisense oligonucleotide targeted against C-raf kinase: Efficient oligonucleotide synthesis without chlorinated solvents, BIO MED CH, 7(3), 1999, pp. 435-439
Authors:
Eleuteri, A
Cheruvallath, ZS
Capaldi, DC
Cole, DL
Ravikumar, VT
Citation: A. Eleuteri et al., Synthesis of dimer phosphoramidite synthons for oligodeoxyribonucleotide phosphorothioates using diethyldithiocarbonate disulfide as an efficient sulfurizing reagent, NUCLEOS NUC, 18(8), 1999, pp. 1803-1807
Authors:
Eleuteri, A
Capaldi, DC
Cole, DL
Ravikumar, VT
Citation: A. Eleuteri et al., Efficient synthesis of deoxyribonucleoside phosphoramidites by eliminatingthe use of additional activator, NUCLEOS NUC, 18(8), 1999, pp. 1879-1882
Authors:
Turney, BJ
Cheruvallath, ZS
Andrade, M
Cole, DL
Ravikumar, VT
Citation: Bj. Turney et al., Stability of phosphorothioate oligonucleotides in aqueous ammonia in presence of stainless steel, NUCLEOS NUC, 18(6-7), 1999, pp. 1187-1189
Authors:
Cheruvallath, ZS
Wyrzykiewicz, TK
Cole, DL
Ravikumar, VT
Citation: Zs. Cheruvallath et al., Diastereomeric process control in the synthesis of oligodeoxyribonucleotide phosphorothioates, NUCLEOS NUC, 18(6-7), 1999, pp. 1191-1194
Authors:
Cheruvallath, ZS
Wheeler, PD
Cole, DL
Ravikumar, VT
Citation: Zs. Cheruvallath et al., Use of phenylacetyl disulfide (PADS) in the synthesis of oligodeoxyribonucleotide phosphorothioates, NUCLEOS NUC, 18(6-7), 1999, pp. 1195-1197
Authors:
Krotz, AH
Cole, DL
Ravikumar, VT
Citation: Ah. Krotz et al., Dimethoxytrityl removal in organic medium: Efficient oligonucleotide synthesis without chlorinated solvents, NUCLEOS NUC, 18(6-7), 1999, pp. 1207-1209
Authors:
Eleuteri, A
Cheruvallath, ZS
Capaldi, DC
Krotz, AH
Cole, DL
Ravikumar, VT
Citation: A. Eleuteri et al., Oligodeoxyribonucleotide phosphorothioates: Substantial reduction of (N-1)-mer content through the use of blockmer phosphoramidite synthons, NUCLEOS NUC, 18(6-7), 1999, pp. 1211-1213